Keyword Connections

•  Adam Seegmiller

•  Charles Flynn

•  W. Jerome

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Publications

• Introduction to lipid biochemistry, metabolism, and signaling.
  Brown HA, Marnett LJ
  (2011) Chem Rev 111: 5817-20
• Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
  Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, Li J, Tang CS, Dorajoo R, Li H, Long J, Guo X, Xu M, Spracklen CN, Chen Y, Liu X, Zhang Y, Khor CC, Liu J, Sun L, Wang L, Gao YT, Hu Y, Yu K, Wang Y, Cheung CYY, Wang F, Huang J, Fan Q, Cai Q, Chen S, Shi J, Yang X, Zhao W, Sheu WH, Cherny SS, He M, Feranil AB, Adair LS, Gordon-Larsen P, Du S, Varma R, Chen YI, Shu XO, Lam KSL, Wong TY, Ganesh SK, Mo Z, Hveem K, Fritsche LG, Nielsen JB, Tse HF, Huo Y, Cheng CY, Chen YE, Zheng W, Tai ES, Gao W, Lin X, Huang W, Abecasis G, GLGC Consortium, Kathiresan S, Mohlke KL, Wu T, Sham PC, Gu D, Willer CJ
  (2017) Nat Genet 49: 1722-1730
• Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
  Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G
  (2005) Nat Genet 37: 1072-81
• The protein kinase IKKepsilon regulates energy balance in obese mice.
  Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR
  (2009) Cell 138: 961-75
• Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.
  Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK
  (2012) Cell 151: 138-52
• Control of pancreas and liver gene expression by HNF transcription factors.
  Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA
  (2004) Science 303: 1378-81
• Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
  An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB
  (2004) Nat Med 10: 268-74
• Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.
  Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS
  (2009) Nat Med 15: 1383-91
• Systems analysis of protein modification and cellular responses induced by electrophile stress.
  Jacobs AT, Marnett LJ
  (2010) Acc Chem Res 43: 673-83
• SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
  Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC
  (2013) Mol Cell 50: 686-98
• Interplay between apolipoprotein E and scavenger receptor class B type I controls coronary atherosclerosis and lifespan in the mouse.
  Fazio S, Linton MF
  (2005) Circulation 111: 3349-51
• Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
  Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF
  (2007) Circulation 116: 1404-12
• Insights into G protein structure, function, and regulation.
  Cabrera-Vera TM, Vanhauwe J, Thomas TO, Medkova M, Preininger A, Mazzoni MR, Hamm HE
  (2003) Endocr Rev 24: 765-81
• Molecular cues to implantation.
  Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T, Wang H
  (2004) Endocr Rev 25: 341-73
• Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.
  Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R
  (2012) Cell Metab 15: 691-702
• Working towards an exegesis for lipids in biology.
  Brown HA, Murphy RC
  (2009) Nat Chem Biol 5: 602-6
• Lipid research picks up speed on the slopes of Taos.
  Field SJ, Lamia KA, Rameh LE, Cantley LC
  (2002) Dev Cell 2: 407-10
• Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies.
  Joshi AD, Andersson C, Buch S, Stender S, Noordam R, Weng LC, Weeke PE, Auer PL, Boehm B, Chen C, Choi H, Curhan G, Denny JC, De Vivo I, Eicher JD, Ellinghaus D, Folsom AR, Fuchs C, Gala M, Haessler J, Hofman A, Hu F, Hunter DJ, Janssen HL, Kang JH, Kooperberg C, Kraft P, Kratzer W, Lieb W, Lutsey PL, Darwish Murad S, Nordestgaard BG, Pasquale LR, Reiner AP, Ridker PM, Rimm E, Rose LM, Shaffer CM, Schafmayer C, Tamimi RM, Uitterlinden AG, Völker U, Völzke H, Wakabayashi Y, Wiggs JL, Zhu J, Roden DM, Stricker BH, Tang W, Teumer A, Hampe J, Tybjærg-Hansen A, Chasman DI, Chan AT, Johnson AD
  (2016) Gastroenterology 151: 351-363.e28
• Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.
  Cyrus T, Witztum JL, Rader DJ, Tangirala R, Fazio S, Linton MF, Funk CD
  (1999) J Clin Invest 103: 1597-604
• Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.
  Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro-Perez J, Cohen JC, Hobbs HH
  (2012) J Clin Invest 122: 4130-44
• Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis.
  Winnick JJ, Kraft G, Gregory JM, Edgerton DS, Williams P, Hajizadeh IA, Kamal MZ, Smith M, Farmer B, Scott M, Neal D, Donahue EP, Allen E, Cherrington AD
  (2016) J Clin Invest 126: 2236-48
• Size, stoichiometry, and organization of soluble LC3-associated complexes.
  Kraft LJ, Nguyen TA, Vogel SS, Kenworthy AK
  (2014) Autophagy 10: 861-77
• Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.
  Martínez-Uña M, Varela-Rey M, Cano A, Fernández-Ares L, Beraza N, Aurrekoetxea I, Martínez-Arranz I, García-Rodríguez JL, Buqué X, Mestre D, Luka Z, Wagner C, Alonso C, Finnell RH, Lu SC, Martínez-Chantar ML, Aspichueta P, Mato JM
  (2013) Hepatology 58: 1296-305
• Coordination of Golgi functions by phosphatidylinositol 4-kinases.
  Graham TR, Burd CG
  (2011) Trends Cell Biol 21: 113-21
• Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations.
  Crawford DC, Carlson CS, Rieder MJ, Carrington DP, Yi Q, Smith JD, Eberle MA, Kruglyak L, Nickerson DA
  (2004) Am J Hum Genet 74: 610-22
• Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle.
  Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR
  (2016) Am J Respir Crit Care Med 194: 719-28
• Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.
  de Guzman Strong C, Wertz PW, Wang C, Yang F, Meltzer PS, Andl T, Millar SE, Ho IC, Pai SY, Segre JA
  (2006) J Cell Biol 175: 661-70
• HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
  Ferrari A, Longo R, Fiorino E, Silva R, Mitro N, Cermenati G, Gilardi F, Desvergne B, Andolfo A, Magagnotti C, Caruso D, Fabiani E, Hiebert SW, Crestani M
  (2017) Nat Commun 8: 93
• Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids.
  Pauta M, Rotllan N, Vales F, Fernandez-Hernando A, Allen RM, Ford DA, Marí M, Jiménez W, Baldán A, Morales-Ruiz M, Fernández-Hernando C
  (2013) J Hepatol 59: 731-7
• Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks.
  Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW
  (2008) EMBO J 27: 1017-28
• Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved.
  Park JJ, Kang SJ, De Silva AD, Stanic AK, Casorati G, Hachey DL, Cresswell P, Joyce S
  (2004) Proc Natl Acad Sci U S A 101: 1022-6
• Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.
  Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK
  (2012) Proc Natl Acad Sci U S A 109: 6739-44
• Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.
  Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA
  (2005) Proc Natl Acad Sci U S A 102: 6207-12
• Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs.
  Barlow C, Dennery PA, Shigenaga MK, Smith MA, Morrow JD, Roberts LJ, Wynshaw-Boris A, Levine RL
  (1999) Proc Natl Acad Sci U S A 96: 9915-9
• Lipid metabolism, atherogenesis and CD1-restricted antigen presentation.
  Major AS, Joyce S, Van Kaer L
  (2006) Trends Mol Med 12: 270-8
• The liver.
  Trefts E, Gannon M, Wasserman DH
  (2017) Curr Biol 27: R1147-R1151
• Lipidomics: a mass spectrometry based systems level analysis of cellular lipids.
  Ivanova PT, Milne SB, Myers DS, Brown HA
  (2009) Curr Opin Chem Biol 13: 526-31
• Results of bariatric surgery.
  Hansen EN, Torquati A, Abumrad NN
  (2006) Annu Rev Nutr 26: 481-511
• Metabolic approaches to cancer cachexia.
  Lawson DH, Richmond A, Nixon DW, Rudman D
  (1982) Annu Rev Nutr 2: 277-301
• The Role of Oxysterols in Human Cancer.
  Kloudova A, Guengerich FP, Soucek P
  (2017) Trends Endocrinol Metab 28: 485-496