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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Mutant Proteins are shown below. Double-click or tap a node for more information.
Please note that publication matches are limited to 40 in this view. If you expected more, please view all publication matches for Mutant Proteins.
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- RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).
Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB
(2011) Nature 480: 387-90 - Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K
(2010) Nature 467: 596-9 - FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.
Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller VA, Costa C, Hannon G, Sawyers CL
(2011) Nature 471: 523-6 - Structural basis of ligand binding modes at the neuropeptide Y Y receptor.
Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B
(2018) Nature 556: 520-524 - The structure of human 5-lipoxygenase.
Gilbert NC, Bartlett SG, Waight MT, Neau DB, Boeglin WE, Brash AR, Newcomer ME
(2011) Science 331: 217-9 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Roberts-Galbraith RH, Ohi MD, Ballif BA, Chen JS, McLeod I, McDonald WH, Gygi SP, Yates JR, Gould KL
(2010) Mol Cell 39: 86-99 - Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.
Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, Law I, Pinborg LH, Sitte HH, Loland C, Shi L, Weinstein H, Galli A, Hjermind LE, Møller LB, Gether U
(2014) J Clin Invest 124: 3107-20 - Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.
Walter AO, Sjin RT, Haringsma HJ, Ohashi K, Sun J, Lee K, Dubrovskiy A, Labenski M, Zhu Z, Wang Z, Sheets M, St Martin T, Karp R, van Kalken D, Chaturvedi P, Niu D, Nacht M, Petter RC, Westlin W, Lin K, Jaw-Tsai S, Raponi M, Van Dyke T, Etter J, Weaver Z, Pao W, Singh J, Simmons AD, Harding TC, Allen A
(2013) Cancer Discov 3: 1404-15 - Conformation of receptor-bound visual arrestin.
Kim M, Vishnivetskiy SA, Van Eps N, Alexander NS, Cleghorn WM, Zhan X, Hanson SM, Morizumi T, Ernst OP, Meiler J, Gurevich VV, Hubbell WL
(2012) Proc Natl Acad Sci U S A 109: 18407-12 - Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases.
Baldridge RD, Graham TR
(2012) Proc Natl Acad Sci U S A 109: E290-8 - CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations.
Koval OM, Guan X, Wu Y, Joiner ML, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran RJ, Song LS, Hund TJ, Mohler PJ, Anderson ME
(2010) Proc Natl Acad Sci U S A 107: 4996-5000 - Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8.
Shin Y, Du Y, Collier SE, Ohi MD, Lang MJ, Ohi R
(2015) Proc Natl Acad Sci U S A 112: E3826-35 - Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors.
Franco AT, Johnston E, Krishna U, Yamaoka Y, Israel DA, Nagy TA, Wroblewski LE, Piazuelo MB, Correa P, Peek RM
(2008) Cancer Res 68: 379-87 - Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation.
Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S
(2007) Cell Death Differ 14: 2058-67 - Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer.
Chmielecki J, Peifer M, Jia P, Socci ND, Hutchinson K, Viale A, Zhao Z, Thomas RK, Pao W
(2010) Nucleic Acids Res 38: 6985-96 - β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion.
Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B
(2013) Diabetes 62: 1527-36 - A bioinformatics workflow for variant peptide detection in shotgun proteomics.
Li J, Su Z, Ma ZQ, Slebos RJ, Halvey P, Tabb DL, Liebler DC, Pao W, Zhang B
(2011) Mol Cell Proteomics 10: M110.006536 - Re-evaluation of nondiagnostic biopsies of suspected low-grade glioma using isocitrate dehydrogenase 1 mutation immunohistochemistry.
Anderson MD, Abel TW, Moots PL
(2013) Neuro Oncol 15: 811-3 - Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor.
Vilar M, Charalampopoulos I, Kenchappa RS, Reversi A, Klos-Applequist JM, Karaca E, Simi A, Spuch C, Choi S, Friedman WJ, Ericson J, Schiavo G, Carter BD, Ibáñez CF
(2009) J Cell Sci 122: 3351-7 - 3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer.
McKinley ET, Smith RA, Zhao P, Fu A, Saleh SA, Uddin MI, Washington MK, Coffey RJ, Manning HC
(2013) J Nucl Med 54: 424-30 - Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects.
Yang R, Shi J, Byeon IJ, Ahn J, Sheehan JH, Meiler J, Gronenborn AM, Aiken C
(2012) Retrovirology 9: 30 - Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.
Sarthy AV, Morgan-Lappe SE, Zakula D, Vernetti L, Schurdak M, Packer JC, Anderson MG, Shirasawa S, Sasazuki T, Fesik SW
(2007) Mol Cancer Ther 6: 269-76 - Analyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKs.
Gurevich VV, Gurevich EV
(2015) Crit Rev Biochem Mol Biol 50: 440-52 - Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN.
Mandl A, Sarkes D, Carricaburu V, Jung V, Rameh L
(2007) Mol Cell Biol 27: 8098-112 - Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor.
Shi J, Zhou J, Halambage UD, Shah VB, Burse MJ, Wu H, Blair WS, Butler SL, Aiken C
(2015) J Virol 89: 208-19 - Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency.
Danthi P, Kobayashi T, Holm GH, Hansberger MW, Abel TW, Dermody TS
(2008) J Virol 82: 161-72 - APOBEC3G complexes decrease human immunodeficiency virus type 1 production.
Martin KL, Johnson M, D'Aquila RT
(2011) J Virol 85: 9314-26 - Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice.
Ashbrook AW, Burrack KS, Silva LA, Montgomery SA, Heise MT, Morrison TE, Dermody TS
(2014) J Virol 88: 12180-92 - Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice.
Hooper KA, Crowe JE, Bloom JD
(2015) J Virol 89: 3737-45 - Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function.
Gadlage MJ, Sparks JS, Beachboard DC, Cox RG, Doyle JD, Stobart CC, Denison MR
(2010) J Virol 84: 280-90 - GeLC-MRM quantitation of mutant KRAS oncoprotein in complex biological samples.
Halvey PJ, Ferrone CR, Liebler DC
(2012) J Proteome Res 11: 3908-13 - Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin.
Kim SH, Speirs CK, Solnica-Krezel L, Ess KC
(2011) Dis Model Mech 4: 255-67 - Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome.
Shirey-Rice JK, Klar R, Fentress HM, Redmon SN, Sabb TR, Krueger JJ, Wallace NM, Appalsamy M, Finney C, Lonce S, Diedrich A, Hahn MK
(2013) Dis Model Mech 6: 1001-11 - Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases.
Kotorashvili A, Russo SJ, Mulugeta S, Guttentag S, Beers MF
(2009) J Biol Chem 284: 16667-16678 - Engineering visual arrestin-1 with special functional characteristics.
Vishnivetskiy SA, Chen Q, Palazzo MC, Brooks EK, Altenbach C, Iverson TM, Hubbell WL, Gurevich VV
(2013) J Biol Chem 288: 3394-405 - The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo.
Ryan KJ, Zhou Y, Wente SR
(2007) Mol Biol Cell 18: 886-98 - Multiple protein kinases influence the redistribution of fission yeast Clp1/Cdc14 phosphatase upon genotoxic stress.
Broadus MR, Gould KL
(2012) Mol Biol Cell 23: 4118-28 - Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function.
Henley KD, Gooding KA, Economides AN, Gannon M
(2012) Am J Physiol Endocrinol Metab 303: E752-61 - Soluble mimics of the cytoplasmic face of the human V1-vascular vasopressin receptor bind arrestin2 and calmodulin.
Wu N, Macion-Dazard R, Nithianantham S, Xu Z, Hanson SM, Vishnivetskiy SA, Gurevich VV, Thibonnier M, Shoham M
(2006) Mol Pharmacol 70: 249-58 - Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
Lee HH, Leake BF, Kim RB, Ho RH
(2017) Mol Pharmacol 91: 14-24
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