Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV (1996) Nature 383: 716-9 Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway. Remondino A, Kwon SH, Communal C, Pimentel DR, Sawyer DB, Singh K, Colucci WS (2003) Circ Res 92: 136-8 Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy. Maruyama Y, Nishida M, Sugimoto Y, Tanabe S, Turner JH, Kozasa T, Wada T, Nagao T, Kurose H (2002) Circ Res 91: 961-9 JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer. Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J (2014) Cancer Res 74: 2444-54 Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin. Persons DL, Yazlovitskaya EM, Cui W, Pelling JC (1999) Clin Cancer Res 5: 1007-14 Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK. Spurlock CF, Aune ZT, Tossberg JT, Collins PL, Aune JP, Huston JW, Crooke PS, Olsen NJ, Aune TM (2011) Arthritis Rheum 63: 2606-16 Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators. Wang SE, Yu Y, Criswell TL, Debusk LM, Lin PC, Zent R, Johnson DH, Ren X, Arteaga CL (2010) Oncogene 29: 3335-48 Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice. Yeiser EC, Rutkoski NJ, Naito A, Inoue J, Carter BD (2004) J Neurosci 24: 10521-9 Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor. Vilar M, Charalampopoulos I, Kenchappa RS, Reversi A, Klos-Applequist JM, Karaca E, Simi A, Spuch C, Choi S, Friedman WJ, Ericson J, Schiavo G, Carter BD, Ibáñez CF (2009) J Cell Sci 122: 3351-7 TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. Harlin H, Podack E, Boothby M, Alegre ML (2002) J Immunol 169: 2451-9 Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P (2003) Mol Cell Biol 23: 3052-66 c-Jun N-terminal kinase attenuates TNFα signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells. Choi H, Dikalova A, Stark RJ, Lamb FS (2015) Free Radic Biol Med 86: 219-27 LRRC8A channels support TNFα-induced superoxide production by Nox1 which is required for receptor endocytosis. Choi H, Ettinger N, Rohrbough J, Dikalova A, Nguyen HN, Lamb FS (2016) Free Radic Biol Med 101: 413-423 MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes. Xiao L, Pimental DR, Amin JK, Singh K, Sawyer DB, Colucci WS (2001) J Mol Cell Cardiol 33: 779-87 Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells. Komalavilas P, Shah PK, Jo H, Lincoln TM (1999) J Biol Chem 274: 34301-9 Cellular protection mechanisms against extracellular heme. heme-hemopexin, but not free heme, activates the N-terminal c-jun kinase. Eskew JD, Vanacore RM, Sung L, Morales PJ, Smith A (1999) J Biol Chem 274: 638-48 Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. Oh YT, Yue P, Zhou W, Balko JM, Black EP, Owonikoko TK, Khuri FR, Sun SY (2012) J Biol Chem 287: 257-267 Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. Linggi MS, Burke TL, Williams BB, Harrington A, Kraemer R, Hempstead BL, Yoon SO, Carter BD (2005) J Biol Chem 280: 13801-8 Nerve growth factor activation of nuclear factor kappaB through its p75 receptor is an anti-apoptotic signal in RN22 schwannoma cells. Gentry JJ, Casaccia-Bonnefil P, Carter BD (2000) J Biol Chem 275: 7558-65 The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain. Tatsis N, Lannigan DA, Macara IG (1998) J Biol Chem 273: 34631-8 Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. Engel ME, McDonnell MA, Law BK, Moses HL (1999) J Biol Chem 274: 37413-20 G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes. Nishida M, Tanabe S, Maruyama Y, Mangmool S, Urayama K, Nagamatsu Y, Takagahara S, Turner JH, Kozasa T, Kobayashi H, Sato Y, Kawanishi T, Inoue R, Nagao T, Kurose H (2005) J Biol Chem 280: 18434-41 Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells. Feoktistov I, Goldstein AE, Biaggioni I (1999) Mol Pharmacol 55: 726-34 Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal--regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines. Cui W, Yazlovitskaya EM, Mayo MS, Pelling JC, Persons DL (2000) Mol Carcinog 29: 219-28 Association of apoptosis with the inhibition of extracellular signal-regulated protein kinase activity in the tumor necrosis factor alpha-resistant ovarian carcinoma cell line UCI 101. Yazlovitskaya EM, Pelling JC, Persons DL (1999) Mol Carcinog 25: 14-20 Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta. Kuramochi Y, Lim CC, Guo X, Colucci WS, Liao R, Sawyer DB (2004) Am J Physiol Cell Physiol 286: C222-9 Inhibition of endocytosis exacerbates TNF-α-induced endothelial dysfunction via enhanced JNK and p38 activation. Choi H, Nguyen HN, Lamb FS (2014) Am J Physiol Heart Circ Physiol 306: H1154-63 Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. Joo M, Kwon M, Cho YJ, Hu N, Pedchenko TV, Sadikot RT, Blackwell TS, Christman JW (2009) Am J Physiol Lung Cell Mol Physiol 296: L771-9 Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium. Communal C, Colucci WS, Remondino A, Sawyer DB, Port JD, Wichman SE, Bristow MR, Singh K (2002) J Card Fail 8: 86-92 Lysine392, a K63-linked ubiquitination site in NEMO, mediates inflammatory osteoclastogenesis and osteolysis. Alhawagri M, Yamanaka Y, Ballard D, Oltz E, Abu-Amer Y (2012) J Orthop Res 30: 554-60 Unique regulation of c-Jun N-terminal kinase by PYK2/CAK-beta in angiotensin II-stimulated vascular smooth muscle cells. Frank GD, Eguchi S, Motley ED, Sasaki T, Inagami T (2001) Biochem Biophys Res Commun 286: 692-6 ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction. Dieckgraefe BK, Weems DM, Santoro SA, Alpers DH (1997) Biochem Biophys Res Commun 233: 389-94 NFAT4 deficiency results in incomplete liver regeneration following partial hepatectomy. Pierre KB, Jones CM, Pierce JM, Nicoud IB, Earl TM, Chari RS (2009) J Surg Res 154: 226-33
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.