Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer. Short SP, Pilat JM, Barrett CW, Reddy VK, Haberman Y, Hendren JR, Marsh BJ, Keating CE, Motley AK, Hill KE, Zemper AE, Washington MK, Shi C, Chen X, Wilson KT, Hyams JS, Denson LA, Burk RF, Rosen MJ, Williams CS (2021) Gastroenterology 160: 1694-1708.e3 Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS (2015) J Clin Invest 125: 2646-60 Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. Burk RF, Hill KE, Awad JA, Morrow JD, Kato T, Cockell KA, Lyons PR (1995) Hepatology 21: 561-9 Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. Hill KE, Lloyd RS, Burk RF (1993) Proc Natl Acad Sci U S A 90: 537-41 Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Burk RF, Hill KE (2005) Annu Rev Nutr 25: 215-35 Regulation of selenoproteins. Burk RF, Hill KE (1993) Annu Rev Nutr 13: 65-81 Regulation of Selenium Metabolism and Transport. Burk RF, Hill KE (2015) Annu Rev Nutr 35: 109-34 Protection against free radical injury by selenoenzymes. Burk RF (1990) Pharmacol Ther 45: 383-5 Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease. Pitts MW, Kremer PM, Hashimoto AC, Torres DJ, Byrns CN, Williams CS, Berry MJ (2015) J Neurosci 35: 15326-38 Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. Xia Y, Hill KE, Li P, Xu J, Zhou D, Motley AK, Wang L, Byrne DW, Burk RF (2010) Am J Clin Nutr 92: 525-31 Selenoproteins in Tumorigenesis and Cancer Progression. Short SP, Williams CS (2017) Adv Cancer Res 136: 49-83 Maternal-fetal transfer of selenium in the mouse. Burk RF, Olson GE, Hill KE, Winfrey VP, Motley AK, Kurokawa S (2013) FASEB J 27: 3249-56 Molecular biology of selenium with implications for its metabolism. Burk RF (1991) FASEB J 5: 2274-9 Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration. Burk RF, Hill KE, Motley AK, Winfrey VP, Kurokawa S, Mitchell SL, Zhang W (2014) FASEB J 28: 3579-88 Orphan selenoproteins. Burk RF, Hill KE (1999) Bioessays 21: 231-7 Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease. Short SP, Pilat JM, Williams CS (2018) Free Radic Biol Med 127: 26-35 Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1. Kurokawa S, Eriksson S, Rose KL, Wu S, Motley AK, Hill S, Winfrey VP, McDonald WH, Capecchi MR, Atkins JF, Arnér ES, Hill KE, Burk RF (2014) Free Radic Biol Med 69: 67-76 Isoform-specific binding of selenoprotein P to the β-propeller domain of apolipoprotein E receptor 2 mediates selenium supply. Kurokawa S, Bellinger FP, Hill KE, Burk RF, Berry MJ (2014) J Biol Chem 289: 9195-207 Mass spectrometric characterization of full-length rat selenoprotein P and three isoforms shortened at the C terminus. Evidence that three UGA codons in the mRNA open reading frame have alternative functions of specifying selenocysteine insertion or translation termination. Ma S, Hill KE, Caprioli RM, Burk RF (2002) J Biol Chem 277: 12749-54 Heparin-binding histidine and lysine residues of rat selenoprotein P. Hondal RJ, Ma S, Caprioli RM, Hill KE, Burk RF (2001) J Biol Chem 276: 15823-31 Deletion of selenoprotein P alters distribution of selenium in the mouse. Hill KE, Zhou J, McMahan WJ, Motley AK, Atkins JF, Gesteland RF, Burk RF (2003) J Biol Chem 278: 13640-6 The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame. Hill KE, Lloyd RS, Yang JG, Read R, Burk RF (1991) J Biol Chem 266: 10050-3 Isoforms of selenoprotein P in rat plasma. Evidence for a full-length form and another form that terminates at the second UGA in the open reading frame. Himeno S, Chittum HS, Burk RF (1996) J Biol Chem 271: 15769-75 Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2). Kurokawa S, Hill KE, McDonald WH, Burk RF (2012) J Biol Chem 287: 28717-26 Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, Atkins JF, Burk RF (2012) J Biol Chem 287: 40414-24 Selenium and amino acid composition of selenoprotein P, the major selenoprotein in rat serum. Read R, Bellew T, Yang JG, Hill KE, Palmer IS, Burk RF (1990) J Biol Chem 265: 17899-905 Polymorphisms in the Selenoprotein S gene and subclinical cardiovascular disease in the Diabetes Heart Study. Cox AJ, Lehtinen AB, Xu J, Langefeld CD, Freedman BI, Carr JJ, Bowden DW (2013) Acta Diabetol 50: 391-9
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