Oral erythromycin and the risk of sudden death from cardiac causes. Ray WA, Murray KT, Meredith S, Narasimhulu SS, Hall K, Stein CM (2004) N Engl J Med 351: 1089-96 The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB (2003) Nat Med 9: 220-4 Cytochrome P-450 3A4: regulation and role in drug metabolism. Guengerich FP (1999) Annu Rev Pharmacol Toxicol 39: 1-17 A malleable catalyst dominates the metabolism of drugs. Guengerich FP (2006) Proc Natl Acad Sci U S A 103: 13565-6 Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Shimada T, Guengerich FP (1989) Proc Natl Acad Sci U S A 86: 462-5 Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration. Haas DW, Bartlett JA, Andersen JW, Sanne I, Wilkinson GR, Hinkle J, Rousseau F, Ingram CD, Shaw A, Lederman MM, Kim RB, Adult AIDS Clinical Trials Group (2006) Clin Infect Dis 43: 783-6 Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity. Ritchie MD, Haas DW, Motsinger AA, Donahue JP, Erdem H, Raffanti S, Rebeiro P, George AL, Kim RB, Haines JL, Sterling TR (2006) Clin Infect Dis 43: 779-82 Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. Shimada T, Iwasaki M, Martin MV, Guengerich FP (1989) Cancer Res 49: 3218-28 Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes. Shimada T, Guengerich FP (1990) Cancer Res 50: 2036-43 Dual drug delivery of tamoxifen and quercetin: Regulated metabolism for anticancer treatment with nanosponges. Lockhart JN, Stevens DM, Beezer DB, Kravitz A, Harth E (2015) J Control Release 220: 751-7 Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes. Guengerich FP, Shimada T, Yun CH, Yamazaki H, Raney KD, Thier R, Coles B, Harris TM (1994) Environ Health Perspect 102 Suppl 9: 49-53 CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism. Wandel C, Witte JS, Hall JM, Stein CM, Wood AJ, Wilkinson GR (2000) Clin Pharmacol Ther 68: 82-91 Intestinal drug transporter expression and the impact of grapefruit juice in humans. Glaeser H, Bailey DG, Dresser GK, Gregor JC, Schwarz UI, McGrath JS, Jolicoeur E, Lee W, Leake BF, Tirona RG, Kim RB (2007) Clin Pharmacol Ther 81: 362-70 Impact of African herbal medicines on antiretroviral metabolism. Mills E, Foster BC, van Heeswijk R, Phillips E, Wilson K, Leonard B, Kosuge K, Kanfer I (2005) AIDS 19: 95-7 Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study. Ribaudo HJ, Liu H, Schwab M, Schaeffeler E, Eichelbaum M, Motsinger-Reif AA, Ritchie MD, Zanger UM, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford D, Haas DW (2010) J Infect Dis 202: 717-22 16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. Huang Z, Guengerich FP, Kaminsky LS (1998) Carcinogenesis 19: 867-72 In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds. Mast N, Verwilst P, Wilkey CJ, Guengerich FP, Pikuleva IA (2020) J Med Chem 63: 6477-6488 Functional CYP2B6 variants and virologic response to an efavirenz-containing regimen in Port-au-Prince, Haiti. Haas DW, Severe P, Jean Juste MA, Pape JW, Fitzgerald DW (2014) J Antimicrob Chemother 69: 2187-90 Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans. Perera MA, Thirumaran RK, Cox NJ, Hanauer S, Das S, Brimer-Cline C, Lamba V, Schuetz EG, Ratain MJ, Di Rienzo A (2009) Pharmacogenomics J 9: 49-60 Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR (1999) Pharm Res 16: 408-14 Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase. Yamazaki H, Shimada T, Martin MV, Guengerich FP (2001) J Biol Chem 276: 30885-91 Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP (2012) J Biol Chem 287: 29554-67 Inhibition of human cytochrome P450 3A4 by cholesterol. Shinkyo R, Guengerich FP (2011) J Biol Chem 286: 18426-33 Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4. Isin EM, Guengerich FP (2007) J Biol Chem 282: 6863-74 Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes. Guengerich FP, Wilkey CJ, Phan TTN (2019) J Biol Chem 294: 10928-10941 Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps. Krauser JA, Guengerich FP (2005) J Biol Chem 280: 19496-506 Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4. Isin EM, Guengerich FP (2006) J Biol Chem 281: 9127-36 Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis. Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, Guengerich FP (2009) J Biol Chem 284: 24425-31 Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5. Yamazaki H, Johnson WW, Ueng YF, Shimada T, Guengerich FP (1996) J Biol Chem 271: 27438-44 Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. Bork RW, Muto T, Beaune PH, Srivastava PK, Lloyd RS, Guengerich FP (1989) J Biol Chem 264: 910-9 Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity. Hanna IH, Krauser JA, Cai H, Kim MS, Guengerich FP (2001) J Biol Chem 276: 39553-61 Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ (1997) Biochem Pharmacol 53: 111-6 Epidemiological study of urinary 6beta-hydroxycortisol to cortisol ratios and breast cancer risk. Zheng W, Jin F, Dunning LA, Shu XO, Dai Q, Wen WQ, Gao YT, Holtzman JL (2001) Cancer Epidemiol Biomarkers Prev 10: 237-42 Aflatoxin B1 activation in human lung. Kelly JD, Eaton DL, Guengerich FP, Coulombe RA (1997) Toxicol Appl Pharmacol 144: 88-95 Role of pharmacogenomics in dialysis and transplantation. Birdwell K (2014) Curr Opin Nephrol Hypertens 23: 570-7 Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples. Yamazaki H, Inoue K, Shaw PM, Checovich WJ, Guengerich FP, Shimada T (1997) J Pharmacol Exp Ther 283: 434-42 Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. Tirona RG, Leake BF, Wolkoff AW, Kim RB (2003) J Pharmacol Exp Ther 304: 223-8 Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate. Chowdhury G, Murayama N, Okada Y, Uno Y, Shimizu M, Shibata N, Guengerich FP, Yamazaki H (2010) Chem Res Toxicol 23: 1018-24 Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M (2010) Chem Res Toxicol 23: 1921-35
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