Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Huppert SS, Ilagan MX, De Strooper B, Kopan R (2005) Dev Cell 8: 677-88 Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease. Shi J, Wang Q, Johansson JU, Liang X, Woodling NS, Priyam P, Loui TM, Merchant M, Breyer RM, Montine TJ, Andreasson K (2012) Ann Neurol 72: 788-98 Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function. Chen CY, Ingram MF, Rosal PH, Graham TR (1999) J Cell Biol 147: 1223-36 Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. Ou-Yang MH, Kurz JE, Nomura T, Popovic J, Rajapaksha TW, Dong H, Contractor A, Chetkovich DM, Tourtellotte WG, Vassar R (2018) Sci Transl Med 10: Effect of amino acid substitutions on the catalytic and regulatory properties of aspartate transcarbamoylase. Robey EA, Wente SR, Markby DW, Flint A, Yang YR, Schachman HK (1986) Proc Natl Acad Sci U S A 83: 5934-8 Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Hayes MG, Urbanek M, Hivert MF, Armstrong LL, Morrison J, Guo C, Lowe LP, Scheftner DA, Pluzhnikov A, Levine DM, McHugh CP, Ackerman CM, Bouchard L, Brisson D, Layden BT, Mirel D, Doheny KF, Leya MV, Lown-Hecht RN, Dyer AR, Metzger BE, Reddy TE, Cox NJ, Lowe WL, HAPO Study Cooperative Research Group (2013) Diabetes 62: 3282-91 Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. Middleton FA, Mirnics K, Pierri JN, Lewis DA, Levitt P (2002) J Neurosci 22: 2718-29 Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter. Barker EL, Moore KR, Rakhshan F, Blakely RD (1999) J Neurosci 19: 4705-17 Endothelial NO synthase polymorphisms and postural tachycardia syndrome. Garland EM, Winker R, Williams SM, Jiang L, Stanton K, Byrne DW, Biaggioni I, Cascorbi I, Phillips JA, Harris PA, Rüdiger H, Robertson D (2005) Hypertension 46: 1103-10 Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics. Rao SK, Ross JM, Harrison FE, Bernardo A, Reiserer RS, Reiserer RS, Mobley JA, McDonald MP (2015) Neurobiol Dis 78: 45-55 Glutamate spillover augments GABA synthesis and release from axodendritic synapses in rat hippocampus. Stafford MM, Brown MN, Mishra P, Stanwood GD, Mathews GC (2010) Hippocampus 20: 134-44 γ-Aminobutyric acid (GABA) concentration inversely correlates with basal perfusion in human occipital lobe. Donahue MJ, Rane S, Hussey E, Mason E, Pradhan S, Waddell KW, Ally BA (2014) J Cereb Blood Flow Metab 34: 532-41 A signal sequence is sufficient for green fluorescent protein to be routed to regulated secretory granules. El Meskini R, Jin L, Marx R, Bruzzaniti A, Lee J, Emeson R, Mains R (2001) Endocrinology 142: 864-73 Spontaneous cross-linking of proteins at aspartate and asparagine residues is mediated via a succinimide intermediate. Friedrich MG, Wang Z, Schey KL, Truscott RJW (2018) Biochem J 475: 3189-3200 Negatively charged anabaena flavodoxin residues (Asp144 and Glu145) are important for reconstitution of cytochrome P450 17alpha-hydroxylase activity. Jenkins CM, Genzor CG, Fillat MF, Waterman MR, Gómez-Moreno C (1997) J Biol Chem 272: 22509-13 cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds. Mast N, Anderson KW, Johnson KM, Phan TTN, Guengerich FP, Pikuleva IA (2017) J Biol Chem 292: 12934-12946 Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. Datta PK, Chytil A, Gorska AE, Moses HL (1998) J Biol Chem 273: 34671-4 Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2. Mukherjee S, Gurevich VV, Preninger A, Hamm HE, Bader MF, Fazleabas AT, Birnbaumer L, Hunzicker-Dunn M (2002) J Biol Chem 277: 17916-27 Different amino acid substitutions at the same position in the nucleotide-binding site of aspartate transcarbamoylase have diverse effects on the allosteric properties of the enzyme. Wente SR, Schachman HK (1991) J Biol Chem 266: 20833-9 The reovirus sigma1 aspartic acid sandwich: a trimerization motif poised for conformational change. Schelling P, Guglielmi KM, Kirchner E, Paetzold B, Dermody TS, Stehle T (2007) J Biol Chem 282: 11582-9 Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. Brasch F, Ochs M, Kahne T, Guttentag S, Schauer-Vukasinovic V, Derrick M, Johnen G, Kapp N, Muller KM, Richter J, Giller T, Hawgood S, Buhling F (2003) J Biol Chem 278: 49006-14 Aspartate 142 is involved in both hydrolase and dehydrogenase catalytic centers of 10-formyltetrahydrofolate dehydrogenase. Krupenko SA, Wagner C (1999) J Biol Chem 274: 35777-84 Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. Chandu D, Huppert SS, Kopan R (2006) J Neurochem 96: 228-35 Neurochemical and immunocytochemical studies on the distribution of N-acetyl-aspartylglutamate and N-acetyl-aspartate in rat spinal cord and some peripheral nervous tissues. Ory-Lavollée L, Blakely RD, Coyle JT (1987) J Neurochem 48: 895-9 Cleavage C-terminal to Asp leads to covalent crosslinking of long-lived human proteins. Wang Z, Friedrich MG, Truscott RJW, Schey KL (2019) Biochim Biophys Acta Proteins Proteom 1867: 831-839 Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model. Ray KC, Bell KM, Yan J, Gu G, Chung CH, Washington MK, Means AL (2011) PLoS One 6: e16786 Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling. Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L, Flexner C, Alper SL, Lencer WI (2004) Am J Physiol Cell Physiol 286: C998-C1008 Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a. Yengo CM, Ananthanarayanan SK, Brosey CA, Mao S, Tyska MJ (2008) Biophys J 94: L5-7 BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Talati M, West J, Blackwell TR, Loyd JE, Meyrick B (2010) Am J Physiol Lung Cell Mol Physiol 299: L363-73 Posttranslational modifications of the bovine lens beaded filament proteins filensin and CP49. Wang Z, Obidike JE, Schey KL (2010) Invest Ophthalmol Vis Sci 51: 1565-74 An in vivo 1H magnetic resonance spectroscopy study of the deep cerebellar nuclei in children with fetal alcohol spectrum disorders. du Plessis L, Jacobson JL, Jacobson SW, Hess AT, van der Kouwe A, Avison MJ, Molteno CD, Stanton ME, Stanley JA, Peterson BS, Meintjes EM (2014) Alcohol Clin Exp Res 38: 1330-8 Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: structure-activity relationships and simulation of rate constants of individual steps in catalysis. Yun CH, Miller GP, Guengerich FP (2001) Biochemistry 40: 4521-30 Identification of an isoaspartyl linkage formed upon deamidation of bovine calbindin D9k and structural characterization by 2D 1H NMR. Chazin WJ, Kördel J, Thulin E, Hofmann T, Drakenberg T, Forsén S (1989) Biochemistry 28: 8646-53 Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding. Guengerich FP, Miller GP, Hanna IH, Martin MV, Léger S, Black C, Chauret N, Silva JM, Trimble LA, Yergey JA, Nicoll-Griffith DA (2002) Biochemistry 41: 11025-34 Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor. Wilson MH, Limbird LE (2000) Biochemistry 39: 693-700 The capacity of the malate-aspartate shuttle differs between periportal and perivenous hepatocytes from rats. Shiota M, Hiramatsu M, Fujimoto Y, Moriyama M, Kimura K, Ohta M, Sugano T (1994) Arch Biochem Biophys 308: 349-56 Ca2+-dependent activation of the malate-aspartate shuttle by norepinephrine and vasopressin in perfused rat liver. Sugano T, Nishimura K, Sogabe N, Shiota M, Oyama N, Noda S, Ohta M (1988) Arch Biochem Biophys 264: 144-54 Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity. Hanna IH, Kim MS, Guengerich FP (2001) Arch Biochem Biophys 393: 255-61 Methylmalonate toxicity in primary neuronal cultures. McLaughlin BA, Nelson D, Silver IA, Erecinska M, Chesselet MF (1998) Neuroscience 86: 279-90 Comparative analysis of Napsin A, alpha-methylacyl-coenzyme A racemase (AMACR, P504S), and hepatocyte nuclear factor 1 beta as diagnostic markers of ovarian clear cell carcinoma: an immunohistochemical study of 279 ovarian tumours. Fadare O, Zhao C, Khabele D, Parkash V, Quick CM, Gwin K, Desouki MM (2015) Pathology 47: 105-11
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.