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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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- AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA
(2009) Cancer Cell 16: 21-32 - mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM
(2009) Cancer Cell 15: 148-59 - Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.
Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M
(2012) J Exp Med 209: 713-28 - Cell surface expression of glycosylated, nonglycosylated, and truncated forms of a cytoplasmic protein pyruvate kinase.
Hiebert SW, Lamb RA
(1988) J Cell Biol 107: 865-76 - Pyruvate induces torpor in obese mice.
Soto M, Orliaguet L, Reyzer ML, Manier ML, Caprioli RM, Kahn CR
(2018) Proc Natl Acad Sci U S A 115: 810-815 - Effect of glucose, pyruvate, and insulin on type 1 angiotensin II receptor expression in SV40-immortalized rabbit proximal tubule epithelial cells.
Becker BN, Kondo S, Cheng HF, Harris RC
(1997) Kidney Int 52: 87-92 - Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
Hwang JY, Sim X, Wu Y, Liang J, Tabara Y, Hu C, Hara K, Tam CH, Cai Q, Zhao Q, Jee S, Takeuchi F, Go MJ, Ong RT, Ohkubo T, Kim YJ, Zhang R, Yamauchi T, So WY, Long J, Gu D, Lee NR, Kim S, Katsuya T, Oh JH, Liu J, Umemura S, Kim YJ, Jiang F, Maeda S, Chan JC, Lu W, Hixson JE, Adair LS, Jung KJ, Nabika T, Bae JB, Lee MH, Seielstad M, Young TL, Teo YY, Kita Y, Takashima N, Osawa H, Lee SH, Shin MH, Shin DH, Choi BY, Shi J, Gao YT, Xiang YB, Zheng W, Kato N, Yoon M, He J, Shu XO, Ma RC, Kadowaki T, Jia W, Miki T, Qi L, Tai ES, Mohlke KL, Han BG, Cho YS, Kim BJ
(2015) Diabetes 64: 291-8 - Nicotine Adenine Dinucleotides: The Redox Currency of the Cell.
Fessel JP, Oldham WM
(2018) Antioxid Redox Signal 28: 165-166 - The impact of anti-apoptotic gene Bcl-2∆ expression on CHO central metabolism.
Templeton N, Lewis A, Dorai H, Qian EA, Campbell MP, Smith KD, Lang SE, Betenbaugh MJ, Young JD
(2014) Metab Eng 25: 92-102 - Isotopically nonstationary C flux analysis of cyanobacterial isobutyraldehyde production.
Jazmin LJ, Xu Y, Cheah YE, Adebiyi AO, Johnson CH, Young JD
(2017) Metab Eng 42: 9-18 - Carbon and nitrogen provisions alter the metabolic flux in developing soybean embryos.
Allen DK, Young JD
(2013) Plant Physiol 161: 1458-75 - Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload.
Fisher-Wellman KH, Gilliam LAA, Lin CT, Cathey BL, Lark DS, Darrell Neufer P
(2013) Free Radic Biol Med 65: 1201-1208 - Oxidation of C-1 compounds by Pseudomonas sp. MS.
Kung HF, Wagner C
(1970) Biochem J 116: 357-65 - Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.
Fisher-Wellman KH, Lin CT, Ryan TE, Reese LR, Gilliam LA, Cathey BL, Lark DS, Smith CD, Muoio DM, Neufer PD
(2015) Biochem J 467: 271-80 - The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria.
Panov A, Schonfeld P, Dikalov S, Hemendinger R, Bonkovsky HL, Brooks BR
(2009) J Biol Chem 284: 14448-56 - Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.
Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C
(2004) J Biol Chem 279: 20314-26 - Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response.
Rocheleau JV, Head WS, Piston DW
(2004) J Biol Chem 279: 31780-7 - Pancreatic islet beta-cells transiently metabolize pyruvate.
Rocheleau JV, Head WS, Nicholson WE, Powers AC, Piston DW
(2002) J Biol Chem 277: 30914-20 - Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes.
Nazarewicz RR, Salazar G, Patrushev N, San Martin A, Hilenski L, Xiong S, Alexander RW
(2011) J Biol Chem 286: 2886-95 - Glucose uptake and metabolism by cultured human skeletal muscle cells: rate-limiting steps.
Perriott LM, Kono T, Whitesell RR, Knobel SM, Piston DW, Granner DK, Powers AC, May JM
(2001) Am J Physiol Endocrinol Metab 281: E72-80 - Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N
(2002) J Lipid Res 43: 1220-35 - VLDL apolipoprotein B-100, a potential indicator of the isotopic labeling of the hepatic protein synthetic precursor pool in humans: studies with multiple stable isotopically labeled amino acids.
Reeds PJ, Hachey DL, Patterson BW, Motil KJ, Klein PD
(1992) J Nutr 122: 457-66 - Comparative Proteome Profiling during Cardiac Hypertrophy and Myocardial Infarction Reveals Altered Glucose Oxidation by Differential Activation of Pyruvate Dehydrogenase E1 Component Subunit β.
Mitra A, Basak T, Ahmad S, Datta K, Datta R, Sengupta S, Sarkar S
(2015) J Mol Biol 427: 2104-20 - Liver, but not muscle, has an entrainable metabolic memory.
Chen SS, Otero YF, Mulligan KX, Lundblad TM, Williams PE, McGuinness OP
(2014) PLoS One 9: e86164 - Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.
Camarillo JM, Ullery JC, Rose KL, Marnett LJ
(2017) Chem Res Toxicol 30: 635-641 - The capacity of the malate-aspartate shuttle differs between periportal and perivenous hepatocytes from rats.
Shiota M, Hiramatsu M, Fujimoto Y, Moriyama M, Kimura K, Ohta M, Sugano T
(1994) Arch Biochem Biophys 308: 349-56 - Enzymes involved in the assimilation of one-carbon units by Pseudomonas MS.
Wagner C, Levitch ME
(1975) J Bacteriol 122: 905-10 - Acute effect of troglitazone on glucose metabolism in the absence or presence of insulin in perfused rat hindlimb.
Okuno A, Ikeda K, Shiota M, Fujiwara T, Yoshioka S, Sugano T, Horikoshi H
(1997) Metabolism 46: 716-21 - Metabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat.
Pannala VR, Wall ML, Estes SK, Trenary I, O'Brien TP, Printz RL, Vinnakota KC, Reifman J, Shiota M, Young JD, Wallqvist A
(2018) Sci Rep 8: 11678 - Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis.
Stokes AH, Lewis DY, Lash LH, Jerome WG, Grant KW, Aschner M, Vrana KE
(2000) Brain Res 858: 1-8 - Intracellular redox state and stimulation of gluconeogenesis by glucagon and norepinephrine in the perfused rat liver.
Sugano T, Shiota M, Tanaka T, Miyamae Y, Shimada M, Oshino N
(1980) J Biochem 87: 153-66 - Abnormal energy regulation in early life: childhood gene expression may predict subsequent chronic mountain sickness.
Huicho L, Xing G, Qualls C, Rivera-Ch M, Gamboa JL, Verma A, Appenzeller O
(2008) BMC Pediatr 8: 47
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