Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM (2001) Nature 413: 131-8 Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. O'Brien RM, Lucas PC, Forest CD, Magnuson MA, Granner DK (1990) Science 249: 533-7 Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA (2007) Cell Metab 5: 313-20 Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC (2015) J Clin Invest 125: 4447-62 Hepatic energy state is regulated by glucagon receptor signaling in mice. Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH (2009) J Clin Invest 119: 2412-22 Renal bone morphogenetic protein-7 protects against diabetic nephropathy. Wang S, de Caestecker M, Kopp J, Mitu G, Lapage J, Hirschberg R (2006) J Am Soc Nephrol 17: 2504-12 Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. She P, Burgess SC, Shiota M, Flakoll P, Donahue EP, Malloy CR, Sherry AD, Magnuson MA (2003) Diabetes 52: 1649-54 cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young. Stoffel M, Xiang KS, Espinosa R, Cox NJ, Le Beau MM, Bell GI (1993) Hum Mol Genet 2: 1-4 Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. She P, Shiota M, Shelton KD, Chalkley R, Postic C, Magnuson MA (2000) Mol Cell Biol 20: 6508-17 Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene. Petersen DD, Magnuson MA, Granner DK (1988) Mol Cell Biol 8: 96-104 Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Wadzinski BE, Wheat WH, Jaspers S, Peruski LF, Lickteig RL, Johnson GL, Klemm DJ (1993) Mol Cell Biol 13: 2822-34 Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Short MK, Clouthier DE, Schaefer IM, Hammer RE, Magnuson MA, Beale EG (1992) Mol Cell Biol 12: 1007-20 Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Quinn PG, Wong TW, Magnuson MA, Shabb JB, Granner DK (1988) Mol Cell Biol 8: 3467-75 Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Forest CD, O'Brien RM, Lucas PC, Magnuson MA, Granner DK (1990) Mol Endocrinol 4: 1302-10 AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Wang HY, Ducommun S, Quan C, Xie B, Li M, Wasserman DH, Sakamoto K, Mackintosh C, Chen S (2013) Biochem J 449: 479-89 p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis. Cao W, Collins QF, Becker TC, Robidoux J, Lupo EG, Xiong Y, Daniel KW, Floering L, Collins S (2005) J Biol Chem 280: 42731-7 Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone. Magnuson MA, Quinn PG, Granner DK (1987) J Biol Chem 262: 14917-20 The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. Scott DK, O'Doherty RM, Stafford JM, Newgard CB, Granner DK (1998) J Biol Chem 273: 24145-51 Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase II with the phosphoenolpyruvate carboxykinase gene promoter. Duong DT, Waltner-Law ME, Sears R, Sealy L, Granner DK (2002) J Biol Chem 277: 32234-42 Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD (2004) J Biol Chem 279: 48941-9 Gene-altered mice and metabolic flux control. Magnuson MA, She P, Shiota M (2003) J Biol Chem 278: 32485-8 Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice. Millward CA, Desantis D, Hsieh CW, Heaney JD, Pisano S, Olswang Y, Reshef L, Beidelschies M, Puchowicz M, Croniger CM (2010) J Lipid Res 51: 1452-63 Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites. Williams CP, Postic C, Robin D, Robin P, Parrinello J, Shelton K, Printz RL, Magnuson MA, Granner DK, Forest C, Chalkley R (1999) Mol Cell Endocrinol 148: 67-77 Enzymes involved in the assimilation of one-carbon units by Pseudomonas MS. Wagner C, Levitch ME (1975) J Bacteriol 122: 905-10 Immunohistochemical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues. Zimmer DB, Magnuson MA (1990) J Histochem Cytochem 38: 171-8
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