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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Protein Transport are shown below. Double-click or tap a node for more information.
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- Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency.
Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D
(2000) N Engl J Med 342: 541-9 - Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.
Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG
(2017) N Engl J Med 376: 1647-1658 - Inactivating mutations in NPC1L1 and protection from coronary heart disease.
Myocardial Infarction Genetics Consortium Investigators, Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, Asselta R, Merlini PA, Marziliano N, Notarangelo MF, Schick U, Auer P, Assimes TL, Reilly M, Wilensky R, Rader DJ, Hovingh GK, Meitinger T, Kessler T, Kastrati A, Laugwitz KL, Siscovick D, Rotter JI, Hazen SL, Tracy R, Cresci S, Spertus J, Jackson R, Schwartz SM, Natarajan P, Crosby J, Muzny D, Ballantyne C, Rich SS, O'Donnell CJ, Abecasis G, Sunaev S, Nickerson DA, Buring JE, Ridker PM, Chasman DI, Austin E, Kullo IJ, Weeke PE, Shaffer CM, Bastarache LA, Denny JC, Roden DM, Palmer C, Deloukas P, Lin DY, Tang ZZ, Erdmann J, Schunkert H, Danesh J, Marrugat J, Elosua R, Ardissino D, McPherson R, Watkins H, Reiner AP, Wilson JG, Altshuler D, Gibbs RA, Lander ES, Boerwinkle E, Gabriel S, Kathiresan S
(2014) N Engl J Med 371: 2072-82 - Glucose transporter gene and non-insulin-dependent diabetes.
Cox NJ, Xiang KS, Bell GI, Karam JH
(1988) Lancet 2: 793-4 - Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter.
Pacholczyk T, Blakely RD, Amara SG
(1991) Nature 350: 350-4 - Identification of the homologous beige and Chediak-Higashi syndrome genes.
Barbosa MD, Nguyen QA, Tchernev VT, Ashley JA, Detter JC, Blaydes SM, Brandt SJ, Chotai D, Hodgman C, Solari RC, Lovett M, Kingsmore SF
(1996) Nature 382: 262-5 - Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW
(1995) Nature 378: 584-92 - Proteogenomic characterization of human colon and rectal cancer.
Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, Chambers MC, Zimmerman LJ, Shaddox KF, Kim S, Davies SR, Wang S, Wang P, Kinsinger CR, Rivers RC, Rodriguez H, Townsend RR, Ellis MJ, Carr SA, Tabb DL, Coffey RJ, Slebos RJ, Liebler DC, NCI CPTAC
(2014) Nature 513: 382-7 - Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms.
Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA
(2000) Nature 408: 936-43 - Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation.
Lang MR, Lapierre LA, Frotscher M, Goldenring JR, Knapik EW
(2006) Nat Genet 38: 1198-203 - Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase.
Jo D, Nashabi A, Doxsee C, Lin Q, Unutmaz D, Chen J, Ruley HE
(2001) Nat Biotechnol 19: 929-33 - AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly.
Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P
(2005) Cell 120: 663-74 - Cytokinesis monitoring during development; rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in Caulobacter.
Matroule JY, Lam H, Burnette DT, Jacobs-Wagner C
(2004) Cell 118: 579-90 - Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease.
Folkmann AW, Collier SE, Zhan X, Aditi , Ohi MD, Wente SR
(2013) Cell 155: 582-93 - The mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translation.
Bolger TA, Folkmann AW, Tran EJ, Wente SR
(2008) Cell 134: 624-33 - Neurobiology. Dopamine's reversal of fortune.
Blakely RD
(2001) Science 293: 2407-9 - Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Nakagawa T
(2019) Science 366: 1259-1263 - Regulation of chromatin remodeling by inositol polyphosphates.
Steger DJ, Haswell ES, Miller AL, Wente SR, O'Shea EK
(2003) Science 299: 114-6 - Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants.
Ramamoorthy S, Blakely RD
(1999) Science 285: 763-6 - Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration.
Lopez CA, Miller BM, Rivera-Chávez F, Velazquez EM, Byndloss MX, Chávez-Arroyo A, Lokken KL, Tsolis RM, Winter SE, Bäumler AJ
(2016) Science 353: 1249-53 - Systematic identification of signal-activated stochastic gene regulation.
Neuert G, Munsky B, Tan RZ, Teytelman L, Khammash M, van Oudenaarden A
(2013) Science 339: 584-7 - The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity.
Pruenster M, Mudde L, Bombosi P, Dimitrova S, Zsak M, Middleton J, Richmond A, Graham GJ, Segerer S, Nibbs RJ, Rot A
(2009) Nat Immunol 10: 101-8 - Viral evasion of antigen presentation: not just for peptides anymore.
Van Kaer L, Joyce S
(2006) Nat Immunol 7: 795-7 - Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine.
Pirzgalska RM, Seixas E, Seidman JS, Link VM, Sánchez NM, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass CK, Domingos AI
(2017) Nat Med 23: 1309-1318 - Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies.
Unlu G, Qi X, Gamazon ER, Melville DB, Patel N, Rushing AR, Hashem M, Al-Faifi A, Chen R, Li B, Cox NJ, Alkuraya FS, Knapik EW
(2020) Nat Med 26: 98-109 - Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1.
de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F
(2014) Nat Med 20: 904-10 - The functional impact of SLC6 transporter genetic variation.
Hahn MK, Blakely RD
(2007) Annu Rev Pharmacol Toxicol 47: 401-41 - Nuclear mRNA on the move.
Noble KN, Wente SR
(2010) Nat Cell Biol 12: 525-7 - Minimal nuclear pore complexes define FG repeat domains essential for transport.
Strawn LA, Shen T, Shulga N, Goldfarb DS, Wente SR
(2004) Nat Cell Biol 6: 197-206 - Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP
(2014) Nat Cell Biol 16: 841-51 - Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export.
Alcázar-Román AR, Tran EJ, Guo S, Wente SR
(2006) Nat Cell Biol 8: 711-6 - Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.
Grandea AG, Golovina TN, Hamilton SE, Sriram V, Spies T, Brutkiewicz RR, Harty JT, Eisenlohr LC, Van Kaer L
(2000) Immunity 13: 213-22 - Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter.
Clark JA, Deutch AY, Gallipoli PZ, Amara SG
(1992) Neuron 9: 337-48 - Getting the message across: a recent transporter structure shows the way.
Henry LK, DeFelice LJ, Blakely RD
(2006) Neuron 49: 791-6 - Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.
Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES
(2003) Neuron 37: 233-47
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