Keyword Connections

•  Albert Reynolds

•  Tammy Sobolik

Resources

• Cadherin Mouse Monoclonal

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Publications

• Common genetic variants on 5p14.1 associate with autism spectrum disorders.
  Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS, Salyakina D, Imielinski M, Bradfield JP, Sleiman PM, Kim CE, Hou C, Frackelton E, Chiavacci R, Takahashi N, Sakurai T, Rappaport E, Lajonchere CM, Munson J, Estes A, Korvatska O, Piven J, Sonnenblick LI, Alvarez Retuerto AI, Herman EI, Dong H, Hutman T, Sigman M, Ozonoff S, Klin A, Owley T, Sweeney JA, Brune CW, Cantor RM, Bernier R, Gilbert JR, Cuccaro ML, McMahon WM, Miller J, State MW, Wassink TH, Coon H, Levy SE, Schultz RT, Nurnberger JI, Haines JL, Sutcliffe JS, Cook EH, Minshew NJ, Buxbaum JD, Dawson G, Grant SF, Geschwind DH, Pericak-Vance MA, Schellenberg GD, Hakonarson H
  (2009) Nature 459: 528-33
• Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
  Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, Zhang H, McLellan M, Yau C, Kandoth C, Bowlby R, Shen H, Hayat S, Fieldhouse R, Lester SC, Tse GM, Factor RE, Collins LC, Allison KH, Chen YY, Jensen K, Johnson NB, Oesterreich S, Mills GB, Cherniack AD, Robertson G, Benz C, Sander C, Laird PW, Hoadley KA, King TA, TCGA Research Network, Perou CM
  (2015) Cell 163: 506-19
• Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion.
  Crawley SW, Shifrin DA, Grega-Larson NE, McConnell RE, Benesh AE, Mao S, Zheng Y, Zheng QY, Nam KT, Millis BA, Kachar B, Tyska MJ
  (2014) Cell 157: 433-446
• Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.
  Stairs DB, Bayne LJ, Rhoades B, Vega ME, Waldron TJ, Kalabis J, Klein-Szanto A, Lee JS, Katz JP, Diehl JA, Reynolds AB, Vonderheide RH, Rustgi AK
  (2011) Cancer Cell 19: 470-83
• The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.
  Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD
  (2013) Nat Cell Biol 15: 677-87
• Inhibition of RhoA by p120 catenin.
  Anastasiadis PZ, Moon SY, Thoreson MA, Mariner DJ, Crawford HC, Zheng Y, Reynolds AB
  (2000) Nat Cell Biol 2: 637-44
• Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.
  Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, Davis L, Wright NR, Dhodapkar RM, DiCola M, DiLullo NM, Fernandez TV, Fielding-Singh V, Fishman DO, Frahm S, Garagaloyan R, Goh GS, Kammela S, Klei L, Lowe JK, Lund SC, McGrew AD, Meyer KA, Moffat WJ, Murdoch JD, O'Roak BJ, Ober GT, Pottenger RS, Raubeson MJ, Song Y, Wang Q, Yaspan BL, Yu TW, Yurkiewicz IR, Beaudet AL, Cantor RM, Curland M, Grice DE, Günel M, Lifton RP, Mane SM, Martin DM, Shaw CA, Sheldon M, Tischfield JA, Walsh CA, Morrow EM, Ledbetter DH, Fombonne E, Lord C, Martin CL, Brooks AI, Sutcliffe JS, Cook EH, Geschwind D, Roeder K, Devlin B, State MW
  (2011) Neuron 70: 863-85
• E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas.
  Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Terashima M, Motoyama T, Meltzer SJ
  (2000) J Natl Cancer Inst 92: 569-73
• p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate.
  Nyeng P, Heilmann S, Löf-Öhlin ZM, Pettersson NF, Hermann FM, Reynolds AB, Semb H
  (2019) Dev Cell 49: 31-47.e9
• Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland.
  Davis MA, Reynolds AB
  (2006) Dev Cell 10: 21-31
• Hereditary diffuse gastric cancer: more answers or more questions?
  Grady WM, Peek RM
  (2002) Gastroenterology 122: 830-1; discussion 831-2
• Antimetastatic role of Smad4 signaling in colorectal cancer.
  Zhang B, Halder SK, Kashikar ND, Cho YJ, Datta A, Gorden DL, Datta PK
  (2010) Gastroenterology 138: 969-80.e1-3
• Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells.
  Singh AB, Sharma A, Smith JJ, Krishnan M, Chen X, Eschrich S, Washington MK, Yeatman TJ, Beauchamp RD, Dhawan P
  (2011) Gastroenterology 141: 2140-53
• Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer.
  Lee HJ, Nam KT, Park HS, Kim MA, Lafleur BJ, Aburatani H, Yang HK, Kim WH, Goldenring JR
  (2010) Gastroenterology 139: 213-25.e3
• Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.
  Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell AE, Starchenko A, Ayers GD, Washington MK, Kamath V, Desai K, Gerdes MJ, Solnica-Krezel L, Coffey RJ
  (2014) J Clin Invest 124: 2172-87
• p120-Catenin is required for mouse vascular development.
  Oas RG, Xiao K, Summers S, Wittich KB, Chiasson CM, Martin WD, Grossniklaus HE, Vincent PA, Reynolds AB, Kowalczyk AP
  (2010) Circ Res 106: 941-51
• Protecting your tail: regulation of cadherin degradation by p120-catenin.
  Kowalczyk AP, Reynolds AB
  (2004) Curr Opin Cell Biol 16: 522-7
• Regulation of Rho GTPases by p120-catenin.
  Anastasiadis PZ, Reynolds AB
  (2001) Curr Opin Cell Biol 13: 604-10
• p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells.
  Aono S, Nakagawa S, Reynolds AB, Takeichi M
  (1999) J Cell Biol 145: 551-62
• Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
  Lin F, Chen S, Sepich DS, Panizzi JR, Clendenon SG, Marrs JA, Hamm HE, Solnica-Krezel L
  (2009) J Cell Biol 184: 909-21
• Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions.
  Li D, Zhou J, Wang L, Shin ME, Su P, Lei X, Kuang H, Guo W, Yang H, Cheng L, Tanaka TS, Leckband DE, Reynolds AB, Duan E, Wang F
  (2010) J Cell Biol 191: 631-44
• An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth.
  Dohn MR, Brown MV, Reynolds AB
  (2009) J Cell Biol 184: 437-50
• A core function for p120-catenin in cadherin turnover.
  Davis MA, Ireton RC, Reynolds AB
  (2003) J Cell Biol 163: 525-34
• A novel role for p120 catenin in E-cadherin function.
  Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matrisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB
  (2002) J Cell Biol 159: 465-76
• Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion.
  Thoreson MA, Anastasiadis PZ, Daniel JM, Ireton RC, Wheelock MJ, Johnson KR, Hummingbird DK, Reynolds AB
  (2000) J Cell Biol 148: 189-202
• The Par3 polarity protein is an exocyst receptor essential for mammary cell survival.
  Ahmed SM, Macara IG
  (2017) Nat Commun 8: 14867
• N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.
  Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y
  (2013) Nat Commun 4: 1589
• Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis.
  Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H
  (2014) Nat Commun 5: 4839
• Epithelial organization: new perspective on α-catenin from an ancient source.
  Reynolds AB
  (2011) Curr Biol 21: R430-2
• Epithelial homeostasis.
  Macara IG, Guyer R, Richardson G, Huo Y, Ahmed SM
  (2014) Curr Biol 24: R815-25
• Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.
  Zhang G, Kernan KA, Collins SJ, Cai X, López-Guisa JM, Degen JL, Shvil Y, Eddy AA
  (2007) J Am Soc Nephrol 18: 846-59
• Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract.
  Shao X, Somlo S, Igarashi P
  (2002) J Am Soc Nephrol 13: 1837-46
• Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines.
  Mo YY, Reynolds AB
  (1996) Cancer Res 56: 2633-40
• Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.
  Witta SE, Gemmill RM, Hirsch FR, Coldren CD, Hedman K, Ravdel L, Helfrich B, Dziadziuszko R, Chan DC, Sugita M, Chan Z, Baron A, Franklin W, Drabkin HA, Girard L, Gazdar AF, Minna JD, Bunn PA
  (2006) Cancer Res 66: 944-50
• Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer.
  Song Y, Washington MK, Crawford HC
  (2010) Cancer Res 70: 2115-25
• Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo.
  Andl CD, Fargnoli BB, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK
  (2006) Cancer Res 66: 9878-85
• Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice.
  Riley KG, Pasek RC, Maulis MF, Peek J, Thorel F, Brigstock DR, Herrera PL, Gannon M
  (2015) Diabetes 64: 1284-98
• Coming unglued.
  Peek RM, Schneider BG, Correa P
  (2006) Clin Cancer Res 12: 2951-4
• Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate.
  Orr B, Riddick AC, Stewart GD, Anderson RA, Franco OE, Hayward SW, Thomson AA
  (2012) Oncogene 31: 1130-42
• p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo.
  Reynolds AB, Herbert L, Cleveland JL, Berg ST, Gaut JR
  (1992) Oncogene 7: 2439-45