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•  Jeffrey Balser

•  Lawrence Marnett

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Publications

• Interactions of carcinogen-bound DNA with individual DNA polymerases.
  Guengerich FP
  (2006) Chem Rev 106: 420-52
• Syk tyrosine kinase required for mouse viability and B-cell development.
  Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T
  (1995) Nature 378: 303-6
• NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.
  Huang B, Eberstadt M, Olejniczak ET, Meadows RP, Fesik SW
  (1996) Nature 384: 638-41
• Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
  Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW
  (2000) Nature 408: 1004-8
• NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
  Sun C, Cai M, Gunasekera AH, Meadows RP, Wang H, Chen J, Zhang H, Wu W, Xu N, Ng SC, Fesik SW
  (1999) Nature 401: 818-22
• Intracellular transport of class II MHC molecules directed by invariant chain.
  Lotteau V, Teyton L, Peleraux A, Nilsson T, Karlsson L, Schmid SL, Quaranta V, Peterson PA
  (1990) Nature 348: 600-5
• NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
  Eberstadt M, Huang B, Chen Z, Meadows RP, Ng SC, Zheng L, Lenardo MJ, Fesik SW
  (1998) Nature 392: 941-5
• Regulation of alternative splicing by RNA editing.
  Rueter SM, Dawson TR, Emeson RB
  (1999) Nature 399: 75-80
• An RNA-export mediator with an essential nuclear export signal.
  Murphy R, Wente SR
  (1996) Nature 383: 357-60
• Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.
  Rickert RC, Rajewsky K, Roes J
  (1995) Nature 376: 352-5
• GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4.
  Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB
  (1994) Nature 372: 276-9
• Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.
  Hoogenraad CC, Koekkoek B, Akhmanova A, Krugers H, Dortland B, Miedema M, van Alphen A, Kistler WM, Jaegle M, Koutsourakis M, Van Camp N, Verhoye M, van der Linden A, Kaverina I, Grosveld F, De Zeeuw CI, Galjart N
  (2002) Nat Genet 32: 116-27
• Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome.
  Parks AL, Cook KR, Belvin M, Dompe NA, Fawcett R, Huppert K, Tan LR, Winter CG, Bogart KP, Deal JE, Deal-Herr ME, Grant D, Marcinko M, Miyazaki WY, Robertson S, Shaw KJ, Tabios M, Vysotskaia V, Zhao L, Andrade RS, Edgar KA, Howie E, Killpack K, Milash B, Norton A, Thao D, Whittaker K, Winner MA, Friedman L, Margolis J, Singer MA, Kopczynski C, Curtis D, Kaufman TC, Plowman GD, Duyk G, Francis-Lang HL
  (2004) Nat Genet 36: 288-92
• Functional genomics in mice by tagged sequence mutagenesis.
  Hicks GG, Shi EG, Li XM, Li CH, Pawlak M, Ruley HE
  (1997) Nat Genet 16: 338-44
• High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP.
  Rodríguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, Ayala R, Stewart AF, Dymecki SM
  (2000) Nat Genet 25: 139-40
• A TALE nuclease architecture for efficient genome editing.
  Miller JC, Tan S, Qiao G, Barlow KA, Wang J, Xia DF, Meng X, Paschon DE, Leung E, Hinkley SJ, Dulay GP, Hua KL, Ankoudinova I, Cost GJ, Urnov FD, Zhang HS, Holmes MC, Zhang L, Gregory PD, Rebar EJ
  (2011) Nat Biotechnol 29: 143-8
• Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection.
  Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, Doranz BJ, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Saphire EO, Ward AB, Bukreyev A, Crowe JE
  (2016) Cell 164: 392-405
• Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.
  Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A
  (1998) Cell 95: 379-91
• NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio.
  Liu X, Wang H, Eberstadt M, Schnuchel A, Olejniczak ET, Meadows RP, Schkeryantz JM, Janowick DA, Harlan JE, Harris EA, Staunton DE, Fesik SW
  (1998) Cell 95: 269-77
• Gene therapy insertional mutagenesis insights.
  Davé UP, Jenkins NA, Copeland NG
  (2004) Science 303: 333
• Multiplex genome engineering using CRISPR/Cas systems.
  Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F
  (2013) Science 339: 819-23
• A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore.
  Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ
  (2005) Science 309: 777-81
• Aspirin-like molecules that covalently inactivate cyclooxygenase-2.
  Kalgutkar AS, Crews BC, Rowlinson SW, Garner C, Seibert K, Marnett LJ
  (1998) Science 280: 1268-70
• Selective use of TBP and TFIIB revealed by a TATA-TBP-TFIIB array with altered specificity.
  Tansey WP, Herr W
  (1997) Science 275: 829-31
• Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
  Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR
  (2013) Cancer Cell 23: 93-106
• Extracellular proteins needed for C. elegans mechanosensation.
  Du H, Gu G, William CM, Chalfie M
  (1996) Neuron 16: 183-94
• Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions.
  Nair KS, Hanson SM, Mendez A, Gurevich EV, Kennedy MJ, Shestopalov VI, Vishnivetskiy SA, Chen J, Hurley JB, Gurevich VV, Slepak VZ
  (2005) Neuron 46: 555-67
• Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.
  Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P
  (2015) Mol Cell 59: 176-87
• Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.
  Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W, Olivier AK, Spitz DR, Gius D
  (2010) Mol Cell 40: 893-904
• The juxtamembrane region of the EGF receptor functions as an activation domain.
  Red Brewer M, Choi SH, Alvarado D, Moravcevic K, Pozzi A, Lemmon MA, Carpenter G
  (2009) Mol Cell 34: 641-51
• Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.
  Ohi MD, Feoktistova A, Ren L, Yip C, Cheng Y, Chen JS, Yoon HJ, Wall JS, Huang Z, Penczek PA, Gould KL, Walz T
  (2007) Mol Cell 28: 871-85
• Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
  Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH
  (2005) Circulation 111: 63-9
• Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.
  Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K
  (2010) Cell Metab 12: 398-410
• High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.
  Varshney GK, Pei W, LaFave MC, Idol J, Xu L, Gallardo V, Carrington B, Bishop K, Jones M, Li M, Harper U, Huang SC, Prakash A, Chen W, Sood R, Ledin J, Burgess SM
  (2015) Genome Res 25: 1030-42
• Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment.
  Osipovich AB, Singh A, Ruley HE
  (2005) Genome Res 15: 428-35
• An arginine tetrad as mediator of input-dependent and input-independent ATPases in the clock protein KaiC.
  Pattanayek R, Xu Y, Lamichhane A, Johnson CH, Egli M
  (2014) Acta Crystallogr D Biol Crystallogr 70: 1375-90
• Functional dissection of the signal recognition particle.
  Siegel V, Walter P
  (1988) Trends Biochem Sci 13: 314-6
• Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases.
  O'Maille PE, Malone A, Dellas N, Andes Hess B, Smentek L, Sheehan I, Greenhagen BT, Chappell J, Manning G, Noel JP
  (2008) Nat Chem Biol 4: 617-23
• Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.
  Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS
  (2015) J Clin Invest 125: 2646-60
• Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection.
  Kinchen VJ, Zahid MN, Flyak AI, Soliman MG, Learn GH, Wang S, Davidson E, Doranz BJ, Ray SC, Cox AL, Crowe JE, Bjorkman PJ, Shaw GM, Bailey JR
  (2018) Cell Host Microbe 24: 717-730.e5