Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ (1995) N Engl J Med 332: 1198-203 Oxidative stress, obesity, and breast cancer risk: results from the Shanghai Women's Health Study. Dai Q, Gao YT, Shu XO, Yang G, Milne G, Cai Q, Wen W, Rothman N, Cai H, Li H, Xiang Y, Chow WH, Zheng W (2009) J Clin Oncol 27: 2482-8 Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors. Takahashi K, Nammour TM, Fukunaga M, Ebert J, Morrow JD, Roberts LJ, Hoover RL, Badr KF (1992) J Clin Invest 90: 136-41 Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. Lynch SM, Morrow JD, Roberts LJ, Frei B (1994) J Clin Invest 93: 998-1004 Detection of the major urinary metabolite of prostaglandin D2 in the circulation: demonstration of elevated levels in patients with disorders of systemic mast cell activation. Awad JA, Morrow JD, Roberts LJ (1994) J Allergy Clin Immunol 93: 817-24 Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. Burk RF, Hill KE, Awad JA, Morrow JD, Kato T, Cockell KA, Lyons PR (1995) Hepatology 21: 561-9 Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. King LS, Fukushima M, Banerjee M, Kang KH, Newman JH, Biaggioni I (1991) Circ Res 68: 352-8 No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls. Montine TJ, Shinobu L, Montine KS, Roberts LJ, Kowall NW, Beal MF, Morrow JD (2000) Ann Neurol 48: 950 Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease. Montine TJ, Markesbery WR, Morrow JD, Roberts LJ (1998) Ann Neurol 44: 410-3 The isoprostanes: unique bioactive products of lipid peroxidation. Morrow JD, Roberts LJ (1997) Prog Lipid Res 36: 1-21 Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. Watanabe K, Iguchi Y, Iguchi S, Arai Y, Hayaishi O, Roberts LJ (1986) Proc Natl Acad Sci U S A 83: 1583-7 Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. Wendelborn DF, Seibert K, Roberts LJ (1988) Proc Natl Acad Sci U S A 85: 304-8 Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. Liston TE, Roberts LJ (1985) Proc Natl Acad Sci U S A 82: 6030-4 Inhibition of eicosanoid biosynthesis by glucocorticoids in humans. Sebaldt RJ, Sheller JR, Oates JA, Roberts LJ, FitzGerald GA (1990) Proc Natl Acad Sci U S A 87: 6974-8 A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Morrow JD, Hill KE, Burk RF, Nammour TM, Badr KF, Roberts LJ (1990) Proc Natl Acad Sci U S A 87: 9383-7 (5Z,13E)-(15S)-9 alpha,11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2): formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. Seibert K, Sheller JR, Roberts LJ (1987) Proc Natl Acad Sci U S A 84: 256-60 Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Morrow JD, Awad JA, Boss HJ, Blair IA, Roberts LJ (1992) Proc Natl Acad Sci U S A 89: 10721-5 Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis. Daniel TO, Liu H, Morrow JD, Crews BC, Marnett LJ (1999) Cancer Res 59: 4574-7 Increased CSF F2-isoprostane concentration in probable AD. Montine TJ, Beal MF, Cudkowicz ME, O'Donnell H, Margolin RA, McFarland L, Bachrach AF, Zackert WE, Roberts LJ, Morrow JD (1999) Neurology 52: 562-5 Cerebrospinal fluid F2-isoprostanes are elevated in Huntington's disease. Montine TJ, Beal MF, Robertson D, Cudkowicz ME, Biaggioni I, O'Donnell H, Zackert WE, Roberts LJ, Morrow JD (1999) Neurology 52: 1104-5 Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion. O'Byrne S, Forte P, Roberts LJ, Morrow JD, Johnston A, Anggård E, Leslie RD, Benjamin N (2000) Diabetes 49: 857-62 Oxidative stress and NF-kappaB activation: correlation in patients following allogeneic bone marrow transplantation. Blackwell TS, Christman JW, Hagan T, Price P, Edens T, Morris PE, Wolff SN, Goodman SA, Christman BW (2000) Antioxid Redox Signal 2: 93-102 Subpressor doses of angiotensin II increase plasma F(2)-isoprostanes in rats. Reckelhoff JF, Zhang H, Srivastava K, Roberts LJ, Morrow JD, Romero JC (2000) Hypertension 35: 476-9 Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. Gniwotta C, Morrow JD, Roberts LJ, Kühn H (1997) Arterioscler Thromb Vasc Biol 17: 3236-41 Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels. Voutilainen S, Morrow JD, Roberts LJ, Alfthan G, Alho H, Nyyssönen K, Salonen JT (1999) Arterioscler Thromb Vasc Biol 19: 1263-6 Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. Morrow JD, Awad JA, Oates JA, Roberts LJ (1992) J Invest Dermatol 98: 812-5 Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites. Harris RC, Munger KA, Badr KF, Takahashi K (1990) FASEB J 4: 1654-60 Placental isoprostane is significantly increased in preeclampsia. Walsh SW, Vaughan JE, Wang Y, Roberts LJ (2000) FASEB J 14: 1289-96 New developments in the isoprostane pathway: identification of novel highly reactive gamma-ketoaldehydes (isolevuglandins) and characterization of their protein adducts. Roberts LJ, Salomon RG, Morrow JD, Brame CJ (1999) FASEB J 13: 1157-68 The isoprostanes: unique prostaglandin-like products of free-radical-initiated lipid peroxidation. Morrow JD, Chen Y, Brame CJ, Yang J, Sanchez SC, Xu J, Zackert WE, Awad JA, Roberts LJ (1999) Drug Metab Rev 31: 117-39 In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW (1996) J Immunol 157: 1630-7 Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils. A potential mast cell-eosinophil interaction. Parsons WG, Roberts LJ (1988) J Immunol 141: 2413-9 Identification and relative quantitation of F2-isoprostane regioisomers formed in vivo in the rat. Waugh RJ, Morrow JD, Roberts LJ, Murphy RC (1997) Free Radic Biol Med 23: 943-54 Comments on prostaglandin F2 alpha rises in response to hydroxyl radical generated in vivo. Awad J, Morrow J, Roberts LJ (1995) Free Radic Biol Med 19: 944-6 Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Roberts LJ, Morrow JD (2000) Free Radic Biol Med 28: 505-13 Quantification of noncyclooxygenase derived prostanoids as a marker of oxidative stress. Morrow JD, Roberts LJ (1991) Free Radic Biol Med 10: 195-200 Oxidant stress but not thromboxane decreases with epoprostenol therapy. Robbins IM, Morrow JD, Christman BW (2005) Free Radic Biol Med 38: 568-74 Oxidative stress, microvascular dysfunction, and scleroderma: an association with potential therapeutic implications, a commentary on "Postocclusive reactive hyperemia inversely correlates with urinary 15-F2t-isoprostane levels in systemic sclerosis". Chung CP, Avalos I, Stein CM (2006) Free Radic Biol Med 40: 1698-9 Demonstration of halothane-induced hepatic lipid peroxidation in rats by quantification of F2-isoprostanes. Awad JA, Horn JL, Roberts LJ, Franks JJ (1996) Anesthesiology 84: 910-6 Greater propensity of diabetic myocardium for oxidative stress after myocardial infarction is associated with the development of heart failure. Smith HM, Hamblin M, Hill MF (2005) J Mol Cell Cardiol 39: 657-65
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