Structural biology: Anticancer drug target pictured. Waterman MR (2009) Nature 457: 159-60 Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Zhang B, Beeghly-Fadiel A, Long J, Zheng W (2011) Lancet Oncol 12: 477-88 Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase. Yoshimoto FK, Guengerich FP (2014) J Am Chem Soc 136: 15016-25 Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Brown NJ (2013) Nat Rev Nephrol 9: 459-69 A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer. Mayer IA, Abramson VG, Formisano L, Balko JM, Estrada MV, Sanders ME, Juric D, Solit D, Berger MF, Won HH, Li Y, Cantley LC, Winer E, Arteaga CL (2017) Clin Cancer Res 23: 26-34 ErbB receptor signaling and therapeutic resistance to aromatase inhibitors. Shin I, Miller T, Arteaga CL (2006) Clin Cancer Res 12: 1008s-1012s Maintenance of the ratio of bioactive to immunoreactive follicle-stimulating hormone in normal men during chronic luteinizing hormone-releasing hormone agonist administration. Pavlou SN, Dahl KD, Wakefield G, Rivier J, Vale W, Hsueh AJ, Lindner J (1988) J Clin Endocrinol Metab 66: 1005-9 Proliferating human granulosa-lutein cells in long term monolayer culture: expression of aromatase, cholesterol side-chain cleavage, and 3 beta-hydroxysteroid dehydrogenase. McAllister JM, Mason JI, Byrd W, Trant JM, Waterman MR, Simpson ER (1990) J Clin Endocrinol Metab 71: 26-33 Discordant cellular response to presurgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification. Balko JM, Mayer IA, Sanders ME, Miller TW, Kuba MG, Meszoely IM, Wagle N, Garraway LA, Arteaga CL (2012) Mol Cancer Ther 11: 2301-5 CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women. Long JR, Shu XO, Cai Q, Wen W, Kataoka N, Gao YT, Zheng W (2007) Int J Obes (Lond) 31: 418-23 Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort. Castel LD, Hartmann KE, Mayer IA, Saville BR, Alvarez J, Boomershine CS, Abramson VG, Chakravarthy AB, Friedman DL, Cella DF (2013) Cancer 119: 2375-82 Breast cancer. Clinical practice guidelines in oncology. Carlson RW, Allred DC, Anderson BO, Burstein HJ, Carter WB, Edge SB, Erban JK, Farrar WB, Goldstein LJ, Gradishar WJ, Hayes DF, Hudis CA, Jahanzeb M, Kiel K, Ljung BM, Marcom PK, Mayer IA, McCormick B, Nabell LM, Pierce LJ, Reed EC, Smith ML, Somlo G, Theriault RL, Topham NS, Ward JH, Winer EP, Wolff AC, NCCN Breast Cancer Clinical Practice Guidelines Panel (2009) J Natl Compr Canc Netw 7: 122-92 Increased long QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors. Grouthier V, Lebrun-Vignes B, Glazer AM, Touraine P, Funck-Brentano C, Pariente A, Courtillot C, Bachelot A, Roden DM, Moslehi JJ, Salem JE (2018) Heart 104: 1859-1863 HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. Edwards TL, Velez Edwards DR, Villegas R, Cohen SS, Buchowski MS, Fowke JH, Schlundt D, Long J, Long JR, Cai Q, Zheng W, Shu XO, Hargreaves MK, Smith J, Jeffrey S, Williams SM, Signorello LB, Blot WJ, Matthews CE (2012) Am J Epidemiol 175: 11-21 A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis. Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI (2020) J Biol Chem 295: 9998-10007 Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP (2012) J Biol Chem 287: 29554-67 Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1. Sohl CD, Guengerich FP (2010) J Biol Chem 285: 17734-43 Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study. Cai Q, Kataoka N, Li C, Wen W, Smith JR, Gao YT, Shu XO, Zheng W (2008) Cancer Epidemiol Biomarkers Prev 17: 27-32 Polymorphisms in the CYP19A1 (aromatase) gene and endometrial cancer risk in Chinese women. Tao MH, Cai Q, Zhang ZF, Xu WH, Kataoka N, Wen W, Xiang YB, Zheng W, Shu XO (2007) Cancer Epidemiol Biomarkers Prev 16: 943-9 Genetic polymorphisms of the CYP19A1 gene and breast cancer survival. Long JR, Kataoka N, Shu XO, Wen W, Gao YT, Cai Q, Zheng W (2006) Cancer Epidemiol Biomarkers Prev 15: 2115-22 BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews. Raskin L, Lejbkowicz F, Barnett-Griness O, Dishon S, Almog R, Rennert G (2009) Cancer Epidemiol Biomarkers Prev 18: 1617-23 cAMP-dependent and tissue-specific expression of genes encoding steroidogenic enzymes in bovine luteal and granulosa cells in primary culture. Lauber ME, Kagawa N, Waterman MR, Simpson ER (1993) Mol Cell Endocrinol 93: 227-33 Regulation of expression of the genes encoding steroidogenic enzymes in the ovary. Simpson E, Lauber M, Demeter M, Means G, Mahendroo M, Kilgore M, Mendelson C, Waterman M (1992) J Steroid Biochem Mol Biol 41: 409-13 Regulation of expression of the genes encoding steroidogenic enzymes. Simpson E, Lauber M, Demeter M, Stirling D, Rodgers R, Means G, Mahendroo M, Kilgore M, Mendelson C, Waterman M (1991) J Steroid Biochem Mol Biol 40: 45-52 Aromatase is phosphorylated in situ at serine-118. Miller TW, Shin I, Kagawa N, Evans DB, Waterman MR, Arteaga CL (2008) J Steroid Biochem Mol Biol 112: 95-101 Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women. Cai H, Shu XO, Egan KM, Cai Q, Long JR, Gao YT, Zheng W (2008) Pharmacogenet Genomics 18: 657-64 Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome P450 aromatase during the three consecutive oxygen activation steps. Tosha T, Kagawa N, Ohta T, Yoshioka S, Waterman MR, Kitagawa T (2006) Biochemistry 45: 5631-40 Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms. Guengerich FP, Sohl CD, Chowdhury G (2011) Arch Biochem Biophys 507: 126-34 Preimplantation mouse blastocysts fail to express CYP genes required for estrogen biosynthesis. Strömstedt M, Keeney DS, Waterman MR, Paria BC, Conley AJ, Dey SK (1996) Mol Reprod Dev 43: 428-36 Characterization of stable human aromatase expressed in E. coli. Kagawa N, Hori H, Waterman MR, Yoshioka S (2004) Steroids 69: 235-43 Is green tea drinking associated with a later onset of breast cancer? Dai Q, Shu XO, Li H, Yang G, Shrubsole MJ, Cai H, Ji B, Wen W, Franke A, Gao YT, Zheng W (2010) Ann Epidemiol 20: 74-81 The ferrous-oxy complex of human aromatase. Grinkova YV, Denisov IG, Waterman MR, Arase M, Kagawa N, Sligar SG (2008) Biochem Biophys Res Commun 372: 379-82 Role of inhibitors of mammalian target of rapamycin in the treatment of luminal breast cancer. Ciruelos E, Cortes-Funes H, Ghanem I, Manso L, Arteaga C (2013) Anticancer Drugs 24: 769-80
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.