Keyword Connections

•  Lisa Young

•  Qi Zhang

•  Roger Cone

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Communities

• Cone Lab
• Gaddy Lab

Publications

• Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism?
  Chinnery PF, Samuels DC, Elson J, Turnbull DM
  (2002) Lancet 360: 1323-5
• Pif1 family helicases suppress genome instability at G-quadruplex motifs.
  Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA
  (2013) Nature 497: 458-62
• A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.
  Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH
  (2013) Nature 502: 550-4
• G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
  Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD
  (2015) Nature 520: 94-8
• Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
  Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A, Välimäki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR, Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB, Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M, Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP
  (2012) Nature 482: 98-102
• Regulatory factor linked to late-onset diabetes?
  Dutta S, Bonner-Weir S, Montminy M, Wright C
  (1998) Nature 392: 560
• SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
  Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K
  (2021) Nature 599: 136-140
• Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
  van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O'Rahilly S, Simerly RB, INTERVAL, UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS
  (2019) Cell 176: 729-742.e18
• Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.
  Weiss A, Murdoch CC, Edmonds KA, Jordan MR, Monteith AJ, Perera YR, Rodríguez Nassif AM, Petoletti AM, Beavers WN, Munneke MJ, Drury SL, Krystofiak ES, Thalluri K, Wu H, Kruse ARS, DiMarchi RD, Caprioli RM, Spraggins JM, Chazin WJ, Giedroc DP, Skaar EP
  (2022) Cell 185: 2148-2163.e27
• Boning up on ephrin signaling.
  Mundy GR, Elefteriou F
  (2006) Cell 126: 441-3
• Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion.
  Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Bäumler AJ
  (2017) Science 357: 570-575
• Allosteric activators of glucokinase: potential role in diabetes therapy.
  Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF
  (2003) Science 301: 370-3
• Metabolic compensation and circadian resilience in prokaryotic cyanobacteria.
  Johnson CH, Egli M
  (2014) Annu Rev Biochem 83: 221-47
• The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
  Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H
  (2009) Nat Immunol 10: 769-77
• In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.
  Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW, Lancini C, van Lohuizen M
  (2013) Cancer Cell 23: 660-76
• Breaking the gene barrier in schizophrenia.
  Horváth S, Mirnics K
  (2009) Nat Med 15: 488-90
• Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine.
  Pirzgalska RM, Seixas E, Seidman JS, Link VM, Sánchez NM, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass CK, Domingos AI
  (2017) Nat Med 23: 1309-1318
• Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
  Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K
  (2018) Nat Med 24: 1395-1406
• The germ-organ theory of non-communicable diseases.
  Byndloss MX, Bäumler AJ
  (2018) Nat Rev Microbiol 16: 103-110
• Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
  Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR
  (2000) Mol Cell 6: 87-97
• The effect of hypertension and left ventricular hypertrophy on the lower range of coronary autoregulation.
  Harrison DG, Florentine MS, Brooks LA, Cooper SM, Marcus ML
  (1988) Circulation 77: 1108-15
• Pathophysiology of myocardial perfusion in hypertension.
  Harrison DG, Marcus ML, Dellsperger KC, Lamping KG, Tomanek RJ
  (1991) Circulation 83: III14-8
• De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder.
  Hamilton PJ, Campbell NG, Sharma S, Erreger K, Herborg Hansen F, Saunders C, Belovich AN, NIH ARRA Autism Sequencing Consortium, Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A
  (2013) Mol Psychiatry 18: 1315-23
• Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.
  Jacobson DA, Kuznetsov A, Lopez JP, Kash S, Ammälä CE, Philipson LH
  (2007) Cell Metab 6: 229-35
• Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans.
  Gitschlag BL, Kirby CS, Samuels DC, Gangula RD, Mallal SA, Patel MR
  (2016) Cell Metab 24: 91-103
• PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
  Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR
  (2006) Cell Metab 4: 491-7
• Klf15 orchestrates circadian nitrogen homeostasis.
  Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK
  (2012) Cell Metab 15: 311-23
• WNK Kinase Signaling in Ion Homeostasis and Human Disease.
  Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT
  (2017) Cell Metab 25: 285-299
• SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
  Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD
  (2017) Cell Metab 25: 838-855.e15
• Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia.
  Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S, Grace AA
  (2008) Trends Neurosci 31: 234-42
• Metal limitation and toxicity at the interface between host and pathogen.
  Becker KW, Skaar EP
  (2014) FEMS Microbiol Rev 38: 1235-49
• Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).
  Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS
  (2007) J Clin Invest 117: 1926-32
• Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.
  Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ
  (2009) J Clin Invest 119: 3322-8
• Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients.
  Pupim LB, Flakoll PJ, Brouillette JR, Levenhagen DK, Hakim RM, Ikizler TA
  (2002) J Clin Invest 110: 483-92
• p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice.
  Smalley-Freed WG, Efimov A, Burnett PE, Short SP, Davis MA, Gumucio DL, Washington MK, Coffey RJ, Reynolds AB
  (2010) J Clin Invest 120: 1824-35
• Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog.
  Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE, Cherrington AD
  (1987) J Clin Invest 79: 557-65
• Obesity and the beta cell: lessons from leptin.
  Niswender KD, Magnuson MA
  (2007) J Clin Invest 117: 2753-6
• IRF3 promotes adipose inflammation and insulin resistance and represses browning.
  Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED
  (2016) J Clin Invest 126: 2839-54
• Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation.
  Niimura F, Labosky PA, Kakuchi J, Okubo S, Yoshida H, Oikawa T, Ichiki T, Naftilan AJ, Fogo A, Inagami T
  (1995) J Clin Invest 96: 2947-54
• Hepatic β-arrestin 2 is essential for maintaining euglycemia.
  Zhu L, Rossi M, Cui Y, Lee RJ, Sakamoto W, Perry NA, Urs NM, Caron MG, Gurevich VV, Godlewski G, Kunos G, Chen M, Chen W, Wess J
  (2017) J Clin Invest 127: 2941-2945