TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N (2006) Nat Med 12: 107-13 Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Salic A, Lee E, Mayer L, Kirschner MW (2000) Mol Cell 5: 523-32 Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. Lee E, Salic A, Kirschner MW (2001) J Cell Biol 154: 983-93 Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis. Soutto M, Peng D, Katsha A, Chen Z, Piazuelo MB, Washington MK, Belkhiri A, Correa P, El-Rifai W (2015) Gut 64: 1028-39 LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin. Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E (2008) Proc Natl Acad Sci U S A 105: 8032-7 Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood. Sillivan SE, Black YD, Naydenov AV, Vassoler FR, Hanlin RP, Konradi C (2011) Biol Psychiatry 70: 583-92 GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity. Rao R, Patel S, Hao C, Woodgett J, Harris R (2010) J Am Soc Nephrol 21: 428-37 Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation. Thotala DK, Hallahan DE, Yazlovitskaya EM (2008) Cancer Res 68: 5859-68 Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation. Yazlovitskaya EM, Edwards E, Thotala D, Fu A, Osusky KL, Whetsell WO, Boone B, Shinohara ET, Hallahan DE (2006) Cancer Res 66: 11179-86 Protein kinase B/Akt-dependent phosphorylation of glycogen synthase kinase-3beta in irradiated vascular endothelium. Tan J, Geng L, Yazlovitskaya EM, Hallahan DE (2006) Cancer Res 66: 2320-7 Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Thotala DK, Hallahan DE, Yazlovitskaya EM (2012) Cell Death Differ 19: 387-96 Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice. Howard C, Tao S, Yang HC, Fogo AB, Woodgett JR, Harris RC, Rao R (2012) Kidney Int 82: 1000-9 Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog. Ramnanan CJ, Kraft G, Smith MS, Farmer B, Neal D, Williams PE, Lautz M, Farmer T, Donahue EP, Cherrington AD, Edgerton DS (2013) Diabetes 62: 74-84 The aurora kinase A regulates GSK-3beta in gastric cancer cells. Dar AA, Belkhiri A, El-Rifai W (2009) Oncogene 28: 866-75 Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice. Rao R, Hao CM, Redha R, Wasserman DH, McGuinness OP, Breyer MD (2007) Diabetologia 50: 452-60 Interactions between GSK3β and amyloid genes explain variance in amyloid burden. Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Neuroimaging Initiative (2014) Neurobiol Aging 35: 460-5 Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis. Guengerich FP, Sorrells JL, Schmitt S, Krauser JA, Aryal P, Meijer L (2004) J Med Chem 47: 3236-41 Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant. Plyte SE, Feoktistova A, Burke JD, Woodgett JR, Gould KL (1996) Mol Cell Biol 16: 179-91 Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal. Bechard M, Dalton S (2009) Mol Cell Biol 29: 2092-104 Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells. Bechard M, Trost R, Singh AM, Dalton S (2012) Mol Cell Biol 32: 288-96 Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells. Vangamudi B, Zhu S, Soutto M, Belkhiri A, El-Rifai W (2011) Mol Cancer 10: 32 PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites. Tyson DR, Swarthout JT, Jefcoat SC, Partridge NC (2002) Endocrinology 143: 674-82 AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Wang HY, Ducommun S, Quan C, Xie B, Li M, Wasserman DH, Sakamoto K, Mackintosh C, Chen S (2013) Biochem J 449: 479-89 The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. Guo S, Burnette R, Zhao L, Vanderford NL, Poitout V, Hagman DK, Henderson E, Ozcan S, Wadzinski BE, Stein R (2009) J Biol Chem 284: 759-65 Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation. Shao J, Sheng H, DuBois RN, Beauchamp RD (2000) J Biol Chem 275: 22916-24
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