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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Receptors, Notch are shown below. Double-click or tap a node for more information.
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- Comprehensive genomic profiles of small cell lung cancer.
George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK
(2015) Nature 524: 47-53 - Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration.
Lopez CA, Miller BM, Rivera-Chávez F, Velazquez EM, Byndloss MX, Chávez-Arroyo A, Lokken KL, Tsolis RM, Winter SE, Bäumler AJ
(2016) Science 353: 1249-53 - AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC
(2016) Cell Metab 23: 649-62 - Chromosome 19 translocation, overexpression of Notch3, and human lung cancer.
Dang TP, Gazdar AF, Virmani AK, Sepetavec T, Hande KR, Minna JD, Roberts JR, Carbone DP
(2000) J Natl Cancer Inst 92: 1355-7 - Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.
Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M
(2012) J Exp Med 209: 713-28 - p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate.
Nyeng P, Heilmann S, Löf-Öhlin ZM, Pettersson NF, Hermann FM, Reynolds AB, Semb H
(2019) Dev Cell 49: 31-47.e9 - Integrated compensatory network is activated in the absence of NCC phosphorylation.
Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA
(2015) J Clin Invest 125: 2136-50 - Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas.
Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M, Boyer DF, Fujimoto K, Doi R, Kageyama R, Wright CV, Chiba T
(2006) J Clin Invest 116: 1484-93 - Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ
(2007) Genes Dev 21: 2629-43 - Feedback control of growth, differentiation, and morphogenesis of pancreatic endocrine progenitors in an epithelial plexus niche.
Bankaitis ED, Bechard ME, Wright CV
(2015) Genes Dev 29: 2203-16 - A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE
(2008) Genes Dev 22: 166-78 - Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo.
Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS
(2012) Hepatology 55: 233-43 - Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.
Pope JL, Bhat AA, Sharma A, Ahmad R, Krishnan M, Washington MK, Beauchamp RD, Singh AB, Dhawan P
(2014) Gut 63: 622-34 - The transcriptional repressor NKAP is required for the development of iNKT cells.
Thapa P, Das J, McWilliams D, Shapiro M, Sundsbak R, Nelson-Holte M, Tangen S, Anderson J, Desiderio S, Hiebert S, Sant'angelo DB, Shapiro VS
(2013) Nat Commun 4: 1582 - Notch signaling controls multiple steps of pancreatic differentiation.
Murtaugh LC, Stanger BZ, Kwan KM, Melton DA
(2003) Proc Natl Acad Sci U S A 100: 14920-5 - Mind bomb 1 is required for pancreatic β-cell formation.
Horn S, Kobberup S, Jørgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Rønne J, Jensen JN
(2012) Proc Natl Acad Sci U S A 109: 7356-61 - Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.
Haruki N, Kawaguchi KS, Eichenberger S, Massion PP, Olson S, Gonzalez A, Carbone DP, Dang TP
(2005) Cancer Res 65: 3555-61 - The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.
Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, MacKerell AD, Capobianco AJ
(2016) Cancer Res 76: 3593-603 - Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner.
Gowrikumar S, Ahmad R, Uppada SB, Washington MK, Shi C, Singh AB, Dhawan P
(2019) Oncogene 38: 5321-5337 - Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice.
Dang TP, Eichenberger S, Gonzalez A, Olson S, Carbone DP
(2003) Oncogene 22: 1988-97 - Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.
Konishi J, Yi F, Chen X, Vo H, Carbone DP, Dang TP
(2010) Oncogene 29: 589-96 - Notch-independent functions of CSL.
Johnson JE, Macdonald RJ
(2011) Curr Top Dev Biol 97: 55-74 - Loss of polymeric immunoglobulin receptor expression is associated with lung tumourigenesis.
Ocak S, Pedchenko TV, Chen H, Harris FT, Qian J, Polosukhin V, Pilette C, Sibille Y, Gonzalez AL, Massion PP
(2012) Eur Respir J 39: 1171-80 - Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas.
Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD
(2004) Development 131: 4213-24 - Notch1 is required for the coordinate segmentation of somites.
Conlon RA, Reaume AG, Rossant J
(1995) Development 121: 1533-45 - Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis.
Huppert SS, Jacobsen TL, Muskavitch MA
(1997) Development 124: 3283-91 - Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.
Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J
(2012) Development 139: 1744-53 - ROCK-nmMyoII, Notch and gene-dosage link epithelial morphogenesis with cell fate in the pancreatic endocrine-progenitor niche.
Bankaitis ED, Bechard ME, Gu G, Magnuson MA, Wright CVE
(2018) Development 145: - The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation.
Parang B, Rosenblatt D, Williams AD, Washington MK, Revetta F, Short SP, Reddy VK, Hunt A, Shroyer NF, Engel ME, Hiebert SW, Williams CS
(2015) FASEB J 29: 786-95 - T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells.
Sandy AR, Chung J, Toubai T, Shan GT, Tran IT, Friedman A, Blackwell TS, Reddy P, King PD, Maillard I
(2013) J Immunol 190: 5818-28 - PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.
Beres TM, Masui T, Swift GH, Shi L, Henke RM, MacDonald RJ
(2006) Mol Cell Biol 26: 117-30 - Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification.
Engel ME, Nguyen HN, Mariotti J, Hunt A, Hiebert SW
(2010) Mol Cell Biol 30: 1852-63 - Mtg16/Eto2 contributes to murine T-cell development.
Hunt A, Fischer M, Engel ME, Hiebert SW
(2011) Mol Cell Biol 31: 2544-51 - Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation.
Vo K, Amarasinghe B, Washington K, Gonzalez A, Berlin J, Dang TP
(2011) Mol Cancer 10: 138 - Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice.
Serup P, Gustavsen C, Klein T, Potter LA, Lin R, Mullapudi N, Wandzioch E, Hines A, Davis A, Bruun C, Engberg N, Petersen DR, Peterslund JM, Macdonald RJ, Grapin-Botton A, Magnuson MA, Zaret KS
(2012) Dis Model Mech 5: 956-66 - Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice.
Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS
(2011) Dis Model Mech 4: 359-67 - Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj.
Walter TJ, Vanderpool C, Cast AE, Huppert SS
(2014) Am J Pathol 184: 1479-88 - Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.
Mahoney MB, Parks AL, Ruddy DA, Tiong SY, Esengil H, Phan AC, Philandrinos P, Winter CG, Chatterjee R, Huppert K, Fisher WW, L'Archeveque L, Mapa FA, Woo W, Ellis MC, Curtis D
(2006) Genetics 172: 2309-24 - Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.
Kopinke D, Brailsford M, Pan FC, Magnuson MA, Wright CV, Murtaugh LC
(2012) Dev Biol 362: 57-64 - miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development.
Olena AF, Rao MB, Thatcher EJ, Wu SY, Patton JG
(2015) Dev Biol 400: 72-81
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