Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Chang S, Aune TM (2007) Nat Immunol 8: 723-31 Specificity of sn50 for NF-kappa B? Boothby M (2001) Nat Immunol 2: 471-2 The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Hong S, Wilson MT, Serizawa I, Wu L, Singh N, Naidenko OV, Miura T, Haba T, Scherer DC, Wei J, Kronenberg M, Koezuka Y, Van Kaer L (2001) Nat Med 7: 1052-6 Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M (2010) Immunity 32: 743-53 Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. Curotto de Lafaille MA, Muriglan S, Sunshine MJ, Lei Y, Kutchukhidze N, Furtado GC, Wensky AK, Olivares-Villagómez D, Lafaille JJ (2001) J Exp Med 194: 1349-59 H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. Felix NJ, Brickey WJ, Griffiths R, Zhang J, Van Kaer L, Coffman T, Ting JP (2000) J Exp Med 192: 31-40 Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. Yoshimoto T, Min B, Sugimoto T, Hayashi N, Ishikawa Y, Sasaki Y, Hata H, Takeda K, Okumura K, Van Kaer L, Paul WE, Nakanishi K (2003) J Exp Med 197: 997-1005 Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. Das J, Ren G, Zhang L, Roberts AI, Zhao X, Bothwell AL, Van Kaer L, Shi Y, Das G (2009) J Exp Med 206: 2407-16 In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease. Youn J, Chen J, Goenka S, Aronica MA, Mora AL, Correa V, Sheller JR, Boothby M (1998) J Exp Med 188: 1803-16 TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization. Caballero MT, Serra ME, Acosta PL, Marzec J, Gibbons L, Salim M, Rodriguez A, Reynaldi A, Garcia A, Bado D, Buchholz UJ, Hijano DR, Coviello S, Newcomb D, Bellabarba M, Ferolla FM, Libster R, Berenstein A, Siniawaski S, Blumetti V, Echavarria M, Pinto L, Lawrence A, Ossorio MF, Grosman A, Mateu CG, Bayle C, Dericco A, Pellegrini M, Igarza I, Repetto HA, Grimaldi LA, Gudapati P, Polack NR, Althabe F, Shi M, Ferrero F, Bergel E, Stein RT, Peebles RS, Boothby M, Kleeberger SR, Polack FP (2015) J Clin Invest 125: 571-82 Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice. Hong S, Scherer DC, Singh N, Mendiratta SK, Serizawa I, Koezuka Y, Van Kaer L (1999) Immunol Rev 169: 31-44 Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility? James KM, Peebles RS, Hartert TV (2012) J Allergy Clin Immunol 130: 343-51 IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells. Wadsworth SJ, Atsuta R, McIntyre JO, Hackett TL, Singhera GK, Dorscheid DR (2010) J Allergy Clin Immunol 126: 366-74, 374.e1-8 Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells. Aronica MA, Swaidani S, Zhang YH, Mitchell D, Mora AL, McCarthy S, O'Neal J, Topham D, Sheller JR, Boothby M (2004) J Allergy Clin Immunol 114: 1441-8 Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells. Aronica MA, McCarthy S, Swaidani S, Mitchell D, Goral M, Sheller JR, Boothby M (2004) Am J Respir Crit Care Med 169: 587-95 Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors. Adeeku E, Gudapati P, Mendez-Fernandez Y, Van Kaer L, Boothby M (2008) Proc Natl Acad Sci U S A 105: 9307-12 Specialized CC-chemokine secretion by Th1 cells in destructive autoimmune myocarditis. Song HK, Noorchashm H, Lin TH, Moore DJ, Greeley SA, Caton AJ, Naji A (2003) J Autoimmun 21: 295-303 Acute xenograft rejection mediated by antibodies produced independently of TH1/TH2 cytokine profiles. Dujovny N, Varghese A, Shen J, Yin D, Ji S, Ma L, Finnegan A, Chong AS (2002) Am J Transplant 2: 526-34 New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines. Mora AL, Stephenson LM, Enerson B, Youn J, Keegan AD, Boothby M (2003) J Immunol 171: 1891-900 STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation. Williams CL, Schilling MM, Cho SH, Lee K, Wei M, Aditi , Boothby M (2013) J Immunol 191: 678-87 Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation. Corn RA, Hunter C, Liou HC, Siebenlist U, Boothby MR (2005) J Immunol 175: 2102-10 Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. Aronica MA, Mora AL, Mitchell DB, Finn PW, Johnson JE, Sheller JR, Boothby MR (1999) J Immunol 163: 5116-24 IL-7 up-regulates IL-4 production by splenic NK1.1+ and NK1.1- MHC class I-like/CD1-dependent CD4+ T cells. Hameg A, Gouarin C, Gombert JM, Hong S, Van Kaer L, Bach JF, Herbelin A (1999) J Immunol 162: 7067-74 Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. Singh N, Hong S, Scherer DC, Serizawa I, Burdin N, Kronenberg M, Koezuka Y, Van Kaer L (1999) J Immunol 163: 2373-7 IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells. Leite-De-Moraes MC, Hameg A, Pacilio M, Koezuka Y, Taniguchi M, Van Kaer L, Schneider E, Dy M, Herbelin A (2001) J Immunol 166: 945-51 Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. Hayakawa Y, Takeda K, Yagita H, Van Kaer L, Saiki I, Okumura K (2001) J Immunol 166: 6012-8 Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice. Faveeuw C, Angeli V, Fontaine J, Maliszewski C, Capron A, Van Kaer L, Moser M, Capron M, Trottein F (2002) J Immunol 169: 906-12 TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. Harlin H, Podack E, Boothby M, Alegre ML (2002) J Immunol 169: 2451-9 A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation. Zhang F, Liang Z, Matsuki N, Van Kaer L, Joyce S, Wakeland EK, Aune TM (2003) J Immunol 171: 4613-20 Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. Meyer F, Ramanujam KS, Gobert AP, James SP, Wilson KT (2003) J Immunol 171: 3913-7 Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. Ryzhov S, Goldstein AE, Matafonov A, Zeng D, Biaggioni I, Feoktistov I (2004) J Immunol 172: 7726-33 Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells. Hashimoto D, Asakura S, Miyake S, Yamamura T, Van Kaer L, Liu C, Tanimoto M, Teshima T (2005) J Immunol 174: 551-6 Diverse functions of distal regulatory elements at the IFNG locus. Collins PL, Henderson MA, Aune TM (2012) J Immunol 188: 1726-33 STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KT (2013) J Immunol 190: 1849-58 Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene. Chen Y, Rosloniec E, Goral MI, Boothby M, Chen J (2001) J Immunol 166: 4163-9 An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation. Stephenson L, Johns MH, Woodward E, Mora AL, Boothby M (2004) J Immunol 173: 4523-8 Primary gamma delta cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation. Wen L, Barber DF, Pao W, Wong FS, Owen MJ, Hayday A (1998) J Immunol 160: 1965-74 Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis. Olivares-Villagómez D, Wensky AK, Wang Y, Lafaille JJ (2000) J Immunol 164: 5499-507 Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation. Zhou W, Zhang J, Goleniewska K, Dulek DE, Toki S, Newcomb DC, Cephus JY, Collins RD, Wu P, Boothby MR, Peebles RS (2016) J Immunol 197: 1577-86 STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RS (2014) J Virol 88: 9655-72
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.