Viral evasion of antigen presentation: not just for peptides anymore. Van Kaer L, Joyce S (2006) Nat Immunol 7: 795-7 Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. Gonzalez-Aseguinolaza G, Van Kaer L, Bergmann CC, Wilson JM, Schmieg J, Kronenberg M, Nakayama T, Taniguchi M, Koezuka Y, Tsuji M (2002) J Exp Med 195: 617-24 Immune privilege: keeping an eye on natural killer T cells. Hong S, Van Kaer L (1999) J Exp Med 190: 1197-200 CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. Motsinger A, Haas DW, Stanic AK, Van Kaer L, Joyce S, Unutmaz D (2002) J Exp Med 195: 869-79 Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. Yoshimoto T, Min B, Sugimoto T, Hayashi N, Ishikawa Y, Sasaki Y, Hata H, Takeda K, Okumura K, Van Kaer L, Paul WE, Nakanishi K (2003) J Exp Med 197: 997-1005 Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice. Hong S, Scherer DC, Singh N, Mendiratta SK, Serizawa I, Koezuka Y, Van Kaer L (1999) Immunol Rev 169: 31-44 Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S (2009) EMBO J 28: 3579-90 Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Wu L, Parekh VV, Gabriel CL, Bracy DP, Marks-Shulman PA, Tamboli RA, Kim S, Mendez-Fernandez YV, Besra GS, Lomenick JP, Williams B, Wasserman DH, Van Kaer L (2012) Proc Natl Acad Sci U S A 109: E1143-52 Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Stanic AK, De Silva AD, Park JJ, Sriram V, Ichikawa S, Hirabyashi Y, Hayakawa K, Van Kaer L, Brutkiewicz RR, Joyce S (2003) Proc Natl Acad Sci U S A 100: 1849-54 Immunotherapy with ligands of natural killer T cells. Wilson MT, Singh AK, Van Kaer L (2002) Trends Mol Med 8: 225-31 Innate immunity: NKT cells in the spotlight. Van Kaer L, Joyce S (2005) Curr Biol 15: R429-31 Invariant natural killer T cells as sensors and managers of inflammation. Van Kaer L, Parekh VV, Wu L (2013) Trends Immunol 34: 50-8 Natural killer T cells accelerate atherogenesis in mice. Nakai Y, Iwabuchi K, Fujii S, Ishimori N, Dashtsoodol N, Watano K, Mishima T, Iwabuchi C, Tanaka S, Bezbradica JS, Nakayama T, Taniguchi M, Miyake S, Yamamura T, Kitabatake A, Joyce S, Van Kaer L, Onoé K (2004) Blood 104: 2051-9 NKT cells: T lymphocytes with innate effector functions. Van Kaer L (2007) Curr Opin Immunol 19: 354-64 Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model. Yang JQ, Wen X, Liu H, Folayan G, Dong X, Zhou M, Van Kaer L, Singh RR (2007) Arthritis Rheum 56: 1219-33 CD1d-restricted glycolipid antigens: presentation principles, recognition logic and functional consequences. Florence WC, Bhat RK, Joyce S (2008) Expert Rev Mol Med 10: e20 Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo. Renukaradhya GJ, Sriram V, Du W, Gervay-Hague J, Van Kaer L, Brutkiewicz RR (2006) Int J Cancer 118: 3045-53 The in vivo response of invariant natural killer T cells to glycolipid antigens. Parekh VV, Lalani S, Van Kaer L (2007) Int Rev Immunol 26: 31-48 CD1d and natural T cells: how their properties jump-start the immune system. Joyce S (2001) Cell Mol Life Sci 58: 442-69 Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. Yang JQ, Singh AK, Wilson MT, Satoh M, Stanic AK, Park JJ, Hong S, Gadola SD, Mizutani A, Kakumanu SR, Reeves WH, Cerundolo V, Joyce S, Van Kaer L, Singh RR (2003) J Immunol 171: 2142-53 Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells. Mempel M, Ronet C, Suarez F, Gilleron M, Puzo G, Van Kaer L, Lehuen A, Kourilsky P, Gachelin G (2002) J Immunol 168: 365-71 CD1d1-dependent control of the magnitude of an acute antiviral immune response. Roberts TJ, Lin Y, Spence PM, Van Kaer L, Brutkiewicz RR (2004) J Immunol 172: 3454-61 A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation. Zhang F, Liang Z, Matsuki N, Van Kaer L, Joyce S, Wakeland EK, Aune TM (2003) J Immunol 171: 4613-20 Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]. Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S (2003) J Immunol 171: 4539-51 Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice. Faveeuw C, Angeli V, Fontaine J, Maliszewski C, Capron A, Van Kaer L, Moser M, Capron M, Trottein F (2002) J Immunol 169: 906-12 Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum. De Silva AD, Park JJ, Matsuki N, Stanic AK, Brutkiewicz RR, Medof ME, Joyce S (2002) J Immunol 168: 723-33 Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B. Stanic AK, Bezbradica JS, Park JJ, Van Kaer L, Boothby MR, Joyce S (2004) J Immunol 172: 4667-71 Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. Singh N, Hong S, Scherer DC, Serizawa I, Burdin N, Kronenberg M, Koezuka Y, Van Kaer L (1999) J Immunol 163: 2373-7 Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. Adachi K, Tsutsui H, Kashiwamura S, Seki E, Nakano H, Takeuchi O, Takeda K, Okumura K, Van Kaer L, Okamura H, Akira S, Nakanishi K (2001) J Immunol 167: 5928-34 Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells. Hashimoto D, Asakura S, Miyake S, Yamamura T, Van Kaer L, Liu C, Tanimoto M, Teshima T (2005) J Immunol 174: 551-6 NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus. Johnson TR, Hong S, Van Kaer L, Koezuka Y, Graham BS (2002) J Virol 76: 4294-303 Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells. Motsinger A, Azimzadeh A, Stanic AK, Johnson RP, Van Kaer L, Joyce S, Unutmaz D (2003) J Virol 77: 8153-8 CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Yang JQ, Chun T, Liu H, Hong S, Bui H, Van Kaer L, Wang CR, Singh RR (2004) Eur J Immunol 34: 1723-32 Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Osman Y, Kawamura T, Naito T, Takeda K, Van Kaer L, Okumura K, Abo T (2000) Eur J Immunol 30: 1919-28 Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonça-Previato L, Nobrega A, Bellio M (2007) J Leukoc Biol 82: 488-96 Natural killer T cells as targets for immunotherapy of autoimmune diseases. Van Kaer L (2004) Immunol Cell Biol 82: 315-22 Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood. Jing Y, Gravenstein S, Chaganty NR, Chen N, Lyerly KH, Joyce S, Deng Y (2007) Exp Gerontol 42: 719-32 Specific deletion of LDL receptor-related protein on macrophages has skewed in vivo effects on cytokine production by invariant natural killer T cells. Covarrubias R, Wilhelm AJ, Major AS (2014) PLoS One 9: e102236 Natural killer T cells in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Van Kaer L, Wu L, Parekh VV (2015) Immunology 146: 1-10 Generation of cellular immunity to lymphocytic choriomeningitis virus is independent of CD1d1 expression. Spence PM, Sriram V, Van Kaer L, Hobbs JA, Brutkiewicz RR (2001) Immunology 104: 168-74
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