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•  Nathan Brummel

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Publications

• Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
  Hughes CG, Mailloux PT, Devlin JW, Swan JT, Sanders RD, Anzueto A, Jackson JC, Hoskins AS, Pun BT, Orun OM, Raman R, Stollings JL, Kiehl AL, Duprey MS, Bui LN, O'Neal HR, Snyder A, Gropper MA, Guntupalli KK, Stashenko GJ, Patel MB, Brummel NE, Girard TD, Dittus RS, Bernard GR, Ely EW, Pandharipande PP, MENDS2 Study Investigators
  (2021) N Engl J Med 384: 1424-1436
• Long-term cognitive impairment after critical illness.
  Pandharipande PP, Girard TD, Ely EW
  (2014) N Engl J Med 370: 185-6
• Long-term cognitive impairment after critical illness.
  Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW, BRAIN-ICU Study Investigators
  (2013) N Engl J Med 369: 1306-16
• Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.
  Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW, MIND-USA Investigators
  (2018) N Engl J Med 379: 2506-2516
• The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators.
  Connors AF, Speroff T, Dawson NV, Thomas C, Harrell FE, Wagner D, Desbiens N, Goldman L, Wu AW, Califf RM, Fulkerson WJ, Vidaillet H, Broste S, Bellamy P, Lynn J, Knaus WA
  (1996) JAMA 276: 889-97
• Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit.
  Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE, Inouye SK, Bernard GR, Dittus RS
  (2004) JAMA 291: 1753-62
• Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU).
  Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, Truman B, Speroff T, Gautam S, Margolin R, Hart RP, Dittus R
  (2001) JAMA 286: 2703-10
• Predicting future functional status for seriously ill hospitalized adults. The SUPPORT prognostic model.
  Wu AW, Damiano AM, Lynn J, Alzola C, Teno J, Landefeld CS, Desbiens N, Tsevat J, Mayer-Oakes A, Harrell FE, Knaus WA
  (1995) Ann Intern Med 122: 342-50
• The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults. Study to understand prognoses and preferences for outcomes and risks of treatments.
  Knaus WA, Harrell FE, Lynn J, Goldman L, Phillips RS, Connors AF, Dawson NV, Fulkerson WJ, Califf RM, Desbiens N, Layde P, Oye RK, Bellamy PE, Hakim RB, Wagner DP
  (1995) Ann Intern Med 122: 191-203
• Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication.
  Bihorac A, Chawla LS, Shaw AD, Al-Khafaji A, Davison DL, Demuth GE, Fitzgerald R, Gong MN, Graham DD, Gunnerson K, Heung M, Jortani S, Kleerup E, Koyner JL, Krell K, Letourneau J, Lissauer M, Miner J, Nguyen HB, Ortega LM, Self WH, Sellman R, Shi J, Straseski J, Szalados JE, Wilber ST, Walker MG, Wilson J, Wunderink R, Zimmerman J, Kellum JA
  (2014) Am J Respir Crit Care Med 189: 932-9
• Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness.
  Siew ED, Fissell WH, Tripp CM, Blume JD, Wilson MD, Clark AJ, Vincz AJ, Ely EW, Pandharipande PP, Girard TD
  (2017) Am J Respir Crit Care Med 195: 1597-1607
• A Two-Biomarker Model Predicts Mortality in the Critically Ill with Sepsis.
  Mikacenic C, Price BL, Harju-Baker S, O'Mahony DS, Robinson-Cohen C, Radella F, Hahn WO, Katz R, Christiani DC, Himmelfarb J, Liles WC, Wurfel MM
  (2017) Am J Respir Crit Care Med 196: 1004-1011
• Randomized Trial of Apneic Oxygenation during Endotracheal Intubation of the Critically Ill.
  Semler MW, Janz DR, Lentz RJ, Matthews DT, Norman BC, Assad TR, Keriwala RD, Ferrell BA, Noto MJ, McKown AC, Kocurek EG, Warren MA, Huerta LE, Rice TW, FELLOW Investigators, Pragmatic Critical Care Research Group
  (2016) Am J Respir Crit Care Med 193: 273-80
• Incidence and Risk Factors for Intensive Care Unit-related Post-traumatic Stress Disorder in Veterans and Civilians.
  Patel MB, Jackson JC, Morandi A, Girard TD, Hughes CG, Thompson JL, Kiehl AL, Elstad MR, Wasserstein ML, Goodman RB, Beckham JC, Chandrasekhar R, Dittus RS, Ely EW, Pandharipande PP
  (2016) Am J Respir Crit Care Med 193: 1373-81
• Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus.
  Dulek DE, Williams JV, Creech CB, Schulert AK, Frangoul HA, Domm J, Denison MR, Chappell JD
  (2010) Clin Infect Dis 50: 1493-6
• Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections.
  Cohen-Wolkowiez M, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Randolph DA, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Rich W, Brozanski BS, van den Anker J, Blumer J, Laughon M, Watt KM, Kearns GL, Capparelli EV, Martz K, Berezny K, Benjamin DK, Smith PB, Meropenem Study Team
  (2012) Clin Infect Dis 55: 1495-502
• Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults.
  Siew ED, Ware LB, Gebretsadik T, Shintani A, Moons KG, Wickersham N, Bossert F, Ikizler TA
  (2009) J Am Soc Nephrol 20: 1823-32
• Oxidative stress is increased in critically ill patients with acute renal failure.
  Himmelfarb J, McMonagle E, Freedman S, Klenzak J, McMenamin E, Le P, Pupim LB, Ikizler TA, The PICARD Group
  (2004) J Am Soc Nephrol 15: 2449-56
• Survival by dialysis modality in critically ill patients with acute kidney injury.
  Cho KC, Himmelfarb J, Paganini E, Ikizler TA, Soroko SH, Mehta RL, Chertow GM
  (2006) J Am Soc Nephrol 17: 3132-8
• Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury.
  Bouchard J, Soroko SB, Chertow GM, Himmelfarb J, Ikizler TA, Paganini EP, Mehta RL, Program to Improve Care in Acute Renal Disease (PICARD) Study Group
  (2009) Kidney Int 76: 422-7
• Distinct injury markers for the early detection and prognosis of incident acute kidney injury in critically ill adults with preserved kidney function.
  Siew ED, Ware LB, Bian A, Shintani A, Eden SK, Wickersham N, Cripps B, Ikizler TA
  (2013) Kidney Int 84: 786-94
• Downloadable computer models for maintenance but not acute renal replacement therapy.
  Marshall MR, Golper TA
  (2006) Kidney Int 70: 1373-4; author reply 1374
• A critically ill newborn with a distended abdomen.
  Hunley TE, Adams MC, Hernanz-Schulman M, Jabs K
  (2017) Kidney Int 92: 521
• Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury.
  Parr SK, Clark AJ, Bian A, Shintani AK, Wickersham NE, Ware LB, Ikizler TA, Siew ED
  (2015) Kidney Int 87: 640-8
• Acute kidney injury: a not-so-silent disease.
  Siew ED, Furth SL
  (2014) Kidney Int 85: 494-5
• Plasma cytokine levels predict mortality in patients with acute renal failure.
  Simmons EM, Himmelfarb J, Sezer MT, Chertow GM, Mehta RL, Paganini EP, Soroko S, Freedman S, Becker K, Spratt D, Shyr Y, Ikizler TA, PICARD Study Group
  (2004) Kidney Int 65: 1357-65
• Impaired monocyte cytokine production in critically ill patients with acute renal failure.
  Himmelfarb J, Le P, Klenzak J, Freedman S, McMenamin ME, Ikizler TA, PICARD Group
  (2004) Kidney Int 66: 2354-60
• Surgery and Anesthesia Exposure Is Not a Risk Factor for Cognitive Impairment After Major Noncardiac Surgery and Critical Illness.
  Hughes CG, Patel MB, Jackson JC, Girard TD, Geevarghese SK, Norman BC, Thompson JL, Chandrasekhar R, Brummel NE, May AK, Elstad MR, Wasserstein ML, Goodman RB, Moons KG, Dittus RS, Ely EW, Pandharipande PP, MIND-ICU, BRAIN-ICU investigators
  (2017) Ann Surg 265: 1126-1133
• Immortal time bias in critical care.
  Shintani AK, Girard TD, Ely EW
  (2010) Crit Care Med 38: 1229
• Repair of metabolic processes.
  Shipman J, Guy J, Abumrad NN
  (2003) Crit Care Med 31: S512-7
• Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study.
  Checkley W, Martin GS, Brown SM, Chang SY, Dabbagh O, Fremont RD, Girard TD, Rice TW, Howell MD, Johnson SB, O'Brien J, Park PK, Pastores SM, Patil NT, Pietropaoli AP, Putman M, Rotello L, Siner J, Sajid S, Murphy DJ, Sevransky JE, United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study Investigators
  (2014) Crit Care Med 42: 344-56
• Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients.
  Ely EW, Girard TD, Shintani AK, Jackson JC, Gordon SM, Thomason JW, Pun BT, Canonico AE, Light RW, Pandharipande P, Laskowitz DT
  (2007) Crit Care Med 35: 112-7
• The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*.
  Adams Wilson JR, Morandi A, Girard TD, Thompson JL, Boomershine CS, Shintani AK, Ely EW, Pandharipande PP
  (2012) Crit Care Med 40: 835-41
• Immortal time bias in critical care research: application of time-varying Cox regression for observational cohort studies.
  Shintani AK, Girard TD, Eden SK, Arbogast PG, Moons KG, Ely EW
  (2009) Crit Care Med 37: 2939-45
• Daily prognostic estimates for critically ill adults in intensive care units: results from a prospective, multicenter, inception cohort analysis.
  Wagner DP, Knaus WA, Harrell FE, Zimmerman JE, Watts C
  (1994) Crit Care Med 22: 1359-72
• Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study.
  Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, Chang SY, Chong D, Kaufman D, Fremont RD, Girard TD, Hoag J, Johnson SB, Kerlin MP, Liebler J, O'Brien J, O'Keefe T, Park PK, Pastores SM, Patil N, Pietropaoli AP, Putman M, Rice TW, Rotello L, Siner J, Sajid S, Murphy DJ, Martin GS, United States Critical Illness and Injury Trials Group-Critical Illness Outcomes Study Investigators
  (2015) Crit Care Med 43: 2076-84
• Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit.
  Doi K, Negishi K, Ishizu T, Katagiri D, Fujita T, Matsubara T, Yahagi N, Sugaya T, Noiri E
  (2011) Crit Care Med 39: 2464-9
• Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States.
  Rice TW, Rubinson L, Uyeki TM, Vaughn FL, John BB, Miller RR, Higgs E, Randolph AG, Smoot BE, Thompson BT, NHLBI ARDS Network
  (2012) Crit Care Med 40: 1487-98
• Influence of an advance directive on the initiation of life support technology in critically ill cancer patients.
  Kish Wallace S, Martin CG, Shaw AD, Price KJ
  (2001) Crit Care Med 29: 2294-8
• Delirium as a predictor of long-term cognitive impairment in survivors of critical illness.
  Girard TD, Jackson JC, Pandharipande PP, Pun BT, Thompson JL, Shintani AK, Gordon SM, Canonico AE, Dittus RS, Bernard GR, Ely EW
  (2010) Crit Care Med 38: 1513-20