Keyword Connections

•  Barbara Fingleton
•  Christopher Williams

•  Damian Maseda
•  Pandu Gangula

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Publications

• Increased prostaglandin production in ulcerative colitis.
  Gould SR, Brash AR, Conolly ME
  (1977) Lancet 2: 98
• Precision editing of the gut microbiota ameliorates colitis.
  Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE
  (2018) Nature 553: 208-211
• Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion.
  Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Bäumler AJ
  (2017) Science 357: 570-575
• TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
  Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD
  (2015) Science 348: aaa2340
• Colonocyte metabolism shapes the gut microbiota.
  Litvak Y, Byndloss MX, Bäumler AJ
  (2018) Science 362:
• Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration.
  Lopez CA, Miller BM, Rivera-Chávez F, Velazquez EM, Byndloss MX, Chávez-Arroyo A, Lokken KL, Tsolis RM, Winter SE, Bäumler AJ
  (2016) Science 353: 1249-53
• Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
  Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M
  (2013) Cancer Cell 23: 634-46
• Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.
  Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE
  (2019) J Exp Med 216: 2378-2393
• Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.
  An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L
  (2007) J Exp Med 204: 1417-29
• The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis.
  Lashner BA, Provencher KS, Seidner DL, Knesebeck A, Brzezinski A
  (1997) Gastroenterology 112: 29-32
• Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease.
  Biancheri P, Brezski RJ, Di Sabatino A, Greenplate AR, Soring KL, Corazza GR, Kok KB, Rovedatti L, Vossenkämper A, Ahmad N, Snoek SA, Vermeire S, Rutgeerts P, Jordan RE, MacDonald TT
  (2015) Gastroenterology 149: 1564-1574.e3
• Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
  Short SP, Pilat JM, Barrett CW, Reddy VK, Haberman Y, Hendren JR, Marsh BJ, Keating CE, Motley AK, Hill KE, Zemper AE, Washington MK, Shi C, Chen X, Wilson KT, Hyams JS, Denson LA, Burk RF, Rosen MJ, Williams CS
  (2021) Gastroenterology 160: 1694-1708.e3
• No Association Between Pseudopolyps and Colorectal Neoplasia in Patients With Inflammatory Bowel Diseases.
  Mahmoud R, Shah SC, Ten Hove JR, Torres J, Mooiweer E, Castaneda D, Glass J, Elman J, Kumar A, Axelrad J, Ullman T, Colombel JF, Oldenburg B, Itzkowitz SH, Dutch Initiative on Crohn and Colitis
  (2019) Gastroenterology 156: 1333-1344.e3
• Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.
  Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ
  (2008) Gastroenterology 134: 2036-48, 2048.e1-3
• Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8(+) T Cells in Mice With Colitis.
  Punit S, Dubé PE, Liu CY, Girish N, Washington MK, Polk DB
  (2015) Gastroenterology 149: 993-1005.e2
• Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients.
  Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA
  (2017) Gastroenterology 152: 1345-1357.e7
• Sex-Based Differences in Incidence of Inflammatory Bowel Diseases-Pooled Analysis of Population-Based Studies From Western Countries.
  Shah SC, Khalili H, Gower-Rousseau C, Olen O, Benchimol EI, Lynge E, Nielsen KR, Brassard P, Vutcovici M, Bitton A, Bernstein CN, Leddin D, Tamim H, Stefansson T, Loftus EV, Moum B, Tang W, Ng SC, Gearry R, Sincic B, Bell S, Sands BE, Lakatos PL, Végh Z, Ott C, Kaplan GG, Burisch J, Colombel JF
  (2018) Gastroenterology 155: 1079-1089.e3
• KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production.
  Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB
  (2011) Gastroenterology 140: 265-74
• Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
  Gobert AP, Latour YL, Asim M, Barry DP, Allaman MM, Finley JL, Smith TM, McNamara KM, Singh K, Sierra JC, Delgado AG, Luis PB, Schneider C, Washington MK, Piazuelo MB, Zhao S, Coburn LA, Wilson KT
  (2022) Gastroenterology 162: 813-827.e8
• Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis.
  Gobert AP, Boutaud O, Asim M, Zagol-Ikapitte IA, Delgado AG, Latour YL, Finley JL, Singh K, Verriere TG, Allaman MM, Barry DP, McNamara KM, Sierra JC, Amarnath V, Tantawy MN, Bimczok D, Piazuelo MB, Washington MK, Zhao S, Coburn LA, Wilson KT
  (2021) Gastroenterology 160: 1256-1268.e9
• Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB.
  Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk DB
  (2008) Gastroenterology 135: 539-51
• Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis.
  Martinez JA, Williams CS, Amann JM, Ellis TC, Moreno-Miralles I, Washington MK, Gregoli P, Hiebert SW
  (2006) Gastroenterology 131: 579-88
• Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.
  Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS
  (2015) J Clin Invest 125: 2646-60
• Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.
  Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH
  (2004) J Clin Invest 114: 1098-106
• Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
  Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB
  (2011) J Clin Invest 121: 2242-53
• Epidermal growth factor receptor inhibits colitis-associated cancer in mice.
  Dubé PE, Yan F, Punit S, Girish N, McElroy SJ, Washington MK, Polk DB
  (2012) J Clin Invest 122: 2780-92
• Genetic Ablation of Butyrate Utilization Attenuates Gastrointestinal Salmonella Disease.
  Bronner DN, Faber F, Olsan EE, Byndloss MX, Sayed NA, Xu G, Yoo W, Kim D, Ryu S, Lebrilla CB, Bäumler AJ
  (2018) Cell Host Microbe 23: 266-273.e4
• MTG16 contributes to colonic epithelial integrity in experimental colitis.
  Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW
  (2013) Gut 62: 1446-55
• Consecutive negative findings on colonoscopy during surveillance predict a low risk of advanced neoplasia in patients with inflammatory bowel disease with long-standing colitis: results of a 15-year multicentre, multinational cohort study.
  Ten Hove JR, Shah SC, Shaffer SR, Bernstein CN, Castaneda D, Palmela C, Mooiweer E, Elman J, Kumar A, Glass J, Axelrad J, Ullman TA, Colombel JF, Torres J, van Bodegraven AA, Hoentjen F, Jansen JM, de Jong ME, Mahmmod N, van der Meulen-de Jong AE, Ponsioen CY, van der Woude CJ, Itzkowitz SH, Oldenburg B
  (2019) Gut 68: 615-622
• Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.
  Pope JL, Bhat AA, Sharma A, Ahmad R, Krishnan M, Washington MK, Beauchamp RD, Singh AB, Dhawan P
  (2014) Gut 63: 622-34
• BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.
  Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS
  (2017) Gut 66: 852-862
• Intestinal host defense outcome is dictated by PGE production during efferocytosis of infected cells.
  Dejani NN, Orlando AB, Niño VE, Penteado LA, Verdan FF, Bazzano JMR, Codo AC, Salina ACG, Saraiva AC, Avelar MR, Spolidorio LC, Serezani CH, Medeiros AI
  (2018) Proc Natl Acad Sci U S A 115: E8469-E8478
• Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.
  Hardbower DM, Asim M, Luis PB, Singh K, Barry DP, Yang C, Steeves MA, Cleveland JL, Schneider C, Piazuelo MB, Gobert AP, Wilson KT
  (2017) Proc Natl Acad Sci U S A 114: E751-E760
• Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth.
  Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN
  (2014) Proc Natl Acad Sci U S A 111: 7084-9
• Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease.
  Olivares-Villagómez D, Mendez-Fernandez YV, Parekh VV, Lalani S, Vincent TL, Cheroutre H, Van Kaer L
  (2008) Proc Natl Acad Sci U S A 105: 17931-6