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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to NF-kappa B are shown below. Double-click or tap a node for more information.
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- Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fèvre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD
(2012) Nature 488: 49-56 - Immunology: TRIM5 does double duty.
Aiken C, Joyce S
(2011) Nature 472: 305-6 - FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.
Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller VA, Costa C, Hannon G, Sawyers CL
(2011) Nature 471: 523-6 - Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis.
Bushdid PB, Brantley DM, Yull FE, Blaeuer GL, Hoffman LH, Niswander L, Kerr LD
(1998) Nature 392: 615-8 - Nf-kappa B, chemokine gene transcription and tumour growth.
Richmond A
(2002) Nat Rev Immunol 2: 664-74 - p120-catenin mediates inflammatory responses in the skin.
Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E
(2006) Cell 124: 631-44 - The protein kinase IKKepsilon regulates energy balance in obese mice.
Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR
(2009) Cell 138: 961-75 - Junction adhesion molecule is a receptor for reovirus.
Barton ES, Forrest JC, Connolly JL, Chappell JD, Liu Y, Schnell FJ, Nusrat A, Parkos CA, Dermody TS
(2001) Cell 104: 441-51 - VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG, Baldwin AS, Zhang Q
(2018) Science 361: 290-295 - Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.
Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhäuser N, Böhm-Matthaei R, Baeuerle PA, Barde YA
(1996) Science 272: 542-5 - Specificity of sn50 for NF-kappa B?
Boothby M
(2001) Nat Immunol 2: 471-2 - Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M
(2013) Cancer Cell 23: 634-46 - LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.
Wang J, An H, Mayo MW, Baldwin AS, Yarbrough WG
(2007) Cancer Cell 12: 239-51 - Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.
Stairs DB, Bayne LJ, Rhoades B, Vega ME, Waldron TJ, Kalabis J, Klein-Szanto A, Lee JS, Katz JP, Diehl JA, Reynolds AB, Vonderheide RH, Rustgi AK
(2011) Cancer Cell 19: 470-83 - Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT
(2017) Nat Med 23: 997-1003 - Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny.
Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, Hawiger J, Unutmaz D, Van Kaer L, Joyce S
(2006) Immunity 25: 487-97 - Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers.
Vilar M, Charalampopoulos I, Kenchappa RS, Simi A, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman WJ, Schiavo G, Bastiaens PI, Verveer PJ, Carter BD, Ibáñez CF
(2009) Neuron 62: 72-83 - Neurotrophins live or let die: does p75NTR decide?
Carter BD, Lewin GR
(1997) Neuron 18: 187-90 - NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis.
Brown JD, Lin CY, Duan Q, Griffin G, Federation A, Paranal RM, Bair S, Newton G, Lichtman A, Kung A, Yang T, Wang H, Luscinskas FW, Croce K, Bradner JE, Plutzky J
(2014) Mol Cell 56: 219-231 - Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation.
Nickols JC, Valentine W, Kanwal S, Carter BD
(2003) Nat Neurosci 6: 161-7 - Evidence for inflammatory signaling in idiopathic pulmonary artery hypertension: TRPC6 and nuclear factor-kappaB.
Hamid R, Newman JH
(2009) Circulation 119: 2297-8 - Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis.
Babaev VR, Chew JD, Ding L, Davis S, Breyer MD, Breyer RM, Oates JA, Fazio S, Linton MF
(2008) Cell Metab 8: 492-501 - Alterations in NFkappaB activation in T lymphocytes of patients with renal cell carcinoma.
Uzzo RG, Clark PE, Rayman P, Bloom T, Rybicki L, Novick AC, Bukowski RM, Finke JH
(1999) J Natl Cancer Inst 91: 718-21 - Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.
Boothby MR, Mora AL, Scherer DC, Brockman JA, Ballard DW
(1997) J Exp Med 185: 1897-907 - Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.
Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M
(2012) J Exp Med 209: 713-28 - Stimulus-dependent synergism of the antiapoptotic tumor necrosis factor receptor-associated factor 2 (TRAF2) and nuclear factor kappaB pathways.
Lee SY, Kaufman DR, Mora AL, Santana A, Boothby M, Choi Y
(1998) J Exp Med 188: 1381-4 - Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.
Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R
(2009) Dev Cell 17: 49-61 - Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB.
Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk DB
(2008) Gastroenterology 135: 539-51 - Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia.
Katsha A, Soutto M, Sehdev V, Peng D, Washington MK, Piazuelo MB, Tantawy MN, Manning HC, Lu P, Shyr Y, Ecsedy J, Belkhiri A, El-Rifai W
(2013) Gastroenterology 145: 1312-22.e1-8 - Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
Ho JE, Chen WY, Chen MH, Larson MG, McCabe EL, Cheng S, Ghorbani A, Coglianese E, Emilsson V, Johnson AD, Walter S, Franceschini N, O'Donnell CJ, CARDIoGRAM Consortium, CHARGE Inflammation Working Group, Dehghan A, Lu C, Levy D, Newton-Cheh C, CHARGE Heart Failure Working Group, Lin H, Felix JF, Schreiter ER, Vasan RS, Januzzi JL, Lee RT, Wang TJ
(2013) J Clin Invest 123: 4208-18 - Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression.
Serezani CH, Lewis C, Jancar S, Peters-Golden M
(2011) J Clin Invest 121: 671-82 - KIM-1-mediated phagocytosis reduces acute injury to the kidney.
Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV
(2015) J Clin Invest 125: 1620-36 - EGFR regulates macrophage activation and function in bacterial infection.
Hardbower DM, Singh K, Asim M, Verriere TG, Olivares-Villagómez D, Barry DP, Allaman MM, Washington MK, Peek RM, Piazuelo MB, Wilson KT
(2016) J Clin Invest 126: 3296-312 - Loss of TFF1 is associated with activation of NF-κB-mediated inflammation and gastric neoplasia in mice and humans.
Soutto M, Belkhiri A, Piazuelo MB, Schneider BG, Peng D, Jiang A, Washington MK, Kokoye Y, Crowe SE, Zaika A, Correa P, Peek RM, El-Rifai W
(2011) J Clin Invest 121: 1753-67 - Conditional ablation of Ikkb inhibits melanoma tumor development in mice.
Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A
(2010) J Clin Invest 120: 2563-74 - Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart.
Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME
(2009) J Clin Invest 119: 986-96 - Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells.
Hao CM, Yull F, Blackwell T, Kömhoff M, Davis LS, Breyer MD
(2000) J Clin Invest 106: 973-82 - Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease.
O'Donnell SM, Hansberger MW, Connolly JL, Chappell JD, Watson MJ, Pierce JM, Wetzel JD, Han W, Barton ES, Forrest JC, Valyi-Nagy T, Yull FE, Blackwell TS, Rottman JN, Sherry B, Dermody TS
(2005) J Clin Invest 115: 2341-50 - Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells.
Uzzo RG, Rayman P, Kolenko V, Clark PE, Cathcart MK, Bloom T, Novick AC, Bukowski RM, Hamilton T, Finke JH
(1999) J Clin Invest 104: 769-76 - IRF3 promotes adipose inflammation and insulin resistance and represses browning.
Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED
(2016) J Clin Invest 126: 2839-54
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