Keyword Connections

•  Javid Moslehi
•  Kathleen Gould

•  Kevin Haas
•  Walter Chazin

•  William Valentine

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Publications

• Death, destruction, and the proteasome.
  Tansey WP
  (2004) N Engl J Med 351: 393-4
• Immunology: TRIM5 does double duty.
  Aiken C, Joyce S
  (2011) Nature 472: 305-6
• Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
  Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA
  (2007) Nature 445: 394-8
• Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.
  Glessner JT, Wang K, Cai G, Korvatska O, Kim CE, Wood S, Zhang H, Estes A, Brune CW, Bradfield JP, Imielinski M, Frackelton EC, Reichert J, Crawford EL, Munson J, Sleiman PM, Chiavacci R, Annaiah K, Thomas K, Hou C, Glaberson W, Flory J, Otieno F, Garris M, Soorya L, Klei L, Piven J, Meyer KJ, Anagnostou E, Sakurai T, Game RM, Rudd DS, Zurawiecki D, McDougle CJ, Davis LK, Miller J, Posey DJ, Michaels S, Kolevzon A, Silverman JM, Bernier R, Levy SE, Schultz RT, Dawson G, Owley T, McMahon WM, Wassink TH, Sweeney JA, Nurnberger JI, Coon H, Sutcliffe JS, Minshew NJ, Grant SF, Bucan M, Cook EH, Buxbaum JD, Devlin B, Schellenberg GD, Hakonarson H
  (2009) Nature 459: 569-73
• Conducting the mitotic symphony.
  Cortez D, Elledge SJ
  (2000) Nature 406: 354-6
• How the ubiquitin-proteasome system controls transcription.
  Muratani M, Tansey WP
  (2003) Nat Rev Mol Cell Biol 4: 192-201
• Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.
  Veeriah S, Taylor BS, Meng S, Fang F, Yilmaz E, Vivanco I, Janakiraman M, Schultz N, Hanrahan AJ, Pao W, Ladanyi M, Sander C, Heguy A, Holland EC, Paty PB, Mischel PS, Liau L, Cloughesy TF, Mellinghoff IK, Solit DB, Chan TA
  (2010) Nat Genet 42: 77-82
• Germline BAP1 mutations predispose to malignant mesothelioma.
  Testa JR, Cheung M, Pei J, Below JE, Tan Y, Sementino E, Cox NJ, Dogan AU, Pass HI, Trusa S, Hesdorffer M, Nasu M, Powers A, Rivera Z, Comertpay S, Tanji M, Gaudino G, Yang H, Carbone M
  (2011) Nat Genet 43: 1022-5
• De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome.
  Matsuura T, Sutcliffe JS, Fang P, Galjaard RJ, Jiang YH, Benton CS, Rommens JM, Beaudet AL
  (1997) Nat Genet 15: 74-7
• Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons.
  Albrecht U, Sutcliffe JS, Cattanach BM, Beechey CV, Armstrong D, Eichele G, Beaudet AL
  (1997) Nat Genet 17: 75-8
• HIF-1alpha is essential for myeloid cell-mediated inflammation.
  Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS
  (2003) Cell 112: 645-57
• The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing.
  Muratani M, Kung C, Shokat KM, Tansey WP
  (2005) Cell 120: 887-99
• Regulation of transcriptional activation domain function by ubiquitin.
  Salghetti SE, Caudy AA, Chenoweth JG, Tansey WP
  (2001) Science 293: 1651-3
• Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution.
  Lange OF, Lakomek NA, Farès C, Schröder GF, Walter KF, Becker S, Meiler J, Grubmüller H, Griesinger C, de Groot BL
  (2008) Science 320: 1471-5
• Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.
  Verma R, Aravind L, Oania R, McDonald WH, Yates JR, Koonin EV, Deshaies RJ
  (2002) Science 298: 611-5
• Ubiquitin and proteasomes in transcription.
  Geng F, Wenzel S, Tansey WP
  (2012) Annu Rev Biochem 81: 177-201
• Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation.
  Kapur P, Peña-Llopis S, Christie A, Zhrebker L, Pavía-Jiménez A, Rathmell WK, Xie XJ, Brugarolas J
  (2013) Lancet Oncol 14: 159-167
• SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
  Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP
  (2014) Cancer Cell 25: 455-68
• Crashing waves of destruction: the cell cycle and APC(Cdh1) regulation of SCF(Skp2).
  Kurland JF, Tansey WP
  (2004) Cancer Cell 5: 305-6
• Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
  Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S
  (2005) Cancer Cell 8: 155-67
• Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.
  Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC
  (2003) Cancer Cell 3: 75-88
• Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain.
  Flick K, Ouni I, Wohlschlegel JA, Capati C, McDonald WH, Yates JR, Kaiser P
  (2004) Nat Cell Biol 6: 634-41
• Transcriptional regulation: RUPture in the ER.
  Tansey WP
  (2000) Nat Cell Biol 2: E175-7
• Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.
  Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, Davis L, Wright NR, Dhodapkar RM, DiCola M, DiLullo NM, Fernandez TV, Fielding-Singh V, Fishman DO, Frahm S, Garagaloyan R, Goh GS, Kammela S, Klei L, Lowe JK, Lund SC, McGrew AD, Meyer KA, Moffat WJ, Murdoch JD, O'Roak BJ, Ober GT, Pottenger RS, Raubeson MJ, Song Y, Wang Q, Yaspan BL, Yu TW, Yurkiewicz IR, Beaudet AL, Cantor RM, Curland M, Grice DE, Günel M, Lifton RP, Mane SM, Martin DM, Shaw CA, Sheldon M, Tischfield JA, Walsh CA, Morrow EM, Ledbetter DH, Fombonne E, Lord C, Martin CL, Brooks AI, Sutcliffe JS, Cook EH, Geschwind D, Roeder K, Devlin B, State MW
  (2011) Neuron 70: 863-85
• Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3.
  Ezhkova E, Tansey WP
  (2004) Mol Cell 13: 435-42
• Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.
  Ohi MD, Feoktistova A, Ren L, Yip C, Cheng Y, Chen JS, Yoon HJ, Wall JS, Huang Z, Penczek PA, Gould KL, Walz T
  (2007) Mol Cell 28: 871-85
• Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.
  Pruneda JN, Littlefield PJ, Soss SE, Nordquist KA, Chazin WJ, Brzovic PS, Klevit RE
  (2012) Mol Cell 47: 933-42