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•  Charles Flynn

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Publications

• Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
  Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW
  (1995) Nature 378: 584-92
• Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
  Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM
  (2001) Nature 413: 131-8
• Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
  Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI
  (1996) Nature 384: 458-60
• Identification of the homologous beige and Chediak-Higashi syndrome genes.
  Barbosa MD, Nguyen QA, Tchernev VT, Ashley JA, Detter JC, Blaydes SM, Brandt SJ, Chotai D, Hodgman C, Solari RC, Lovett M, Kingsmore SF
  (1996) Nature 382: 262-5
• Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis.
  Gould KL, Nurse P
  (1989) Nature 342: 39-45
• Solution structure of a pleckstrin-homology domain.
  Yoon HS, Hajduk PJ, Petros AM, Olejniczak ET, Meadows RP, Fesik SW
  (1994) Nature 369: 672-5
• Integrin-linked kinase is an adaptor with essential functions during mouse development.
  Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R
  (2009) Nature 461: 1002-6
• Disruption of IRS-2 causes type 2 diabetes in mice.
  Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
  (1998) Nature 391: 900-4
• Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.
  Harlan JE, Hajduk PJ, Yoon HS, Fesik SW
  (1994) Nature 371: 168-70
• Phosphoinositide binding domains: embracing 3-phosphate.
  Fruman DA, Rameh LE, Cantley LC
  (1999) Cell 97: 817-20
• p120-catenin mediates inflammatory responses in the skin.
  Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E
  (2006) Cell 124: 631-44
• Single cell profiling of potentiated phospho-protein networks in cancer cells.
  Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud Ø, Gjertsen BT, Nolan GP
  (2004) Cell 118: 217-28
• p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.
  Wildenberg GA, Dohn MR, Carnahan RH, Davis MA, Lobdell NA, Settleman J, Reynolds AB
  (2006) Cell 127: 1027-39
• The E2F transcription factor is a cellular target for the RB protein.
  Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR
  (1991) Cell 65: 1053-61
• Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
  Rameh LE, Chen CS, Cantley LC
  (1995) Cell 83: 821-30
• TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.
  Pietenpol JA, Stein RW, Moran E, Yaciuk P, Schlegel R, Lyons RM, Pittelkow MR, Münger K, Howley PM, Moses HL
  (1990) Cell 61: 777-85
• Perp is a p63-regulated gene essential for epithelial integrity.
  Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD
  (2005) Cell 120: 843-56
• A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.
  Trofatter JA, MacCollin MM, Rutter JL, Murrell JR, Duyao MP, Parry DM, Eldridge R, Kley N, Menon AG, Pulaski K
  (1993) Cell 72: 791-800
• NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio.
  Liu X, Wang H, Eberstadt M, Schnuchel A, Olejniczak ET, Meadows RP, Schkeryantz JM, Janowick DA, Harlan JE, Harris EA, Staunton DE, Fesik SW
  (1998) Cell 95: 269-77
• Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.
  Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER
  (1998) Cell 92: 25-37
• Cytokinesis monitoring during development; rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in Caulobacter.
  Matroule JY, Lam H, Burnette DT, Jacobs-Wagner C
  (2004) Cell 118: 579-90
• Roles of serine/threonine phosphatases in hippocampal synaptic plasticity.
  Winder DG, Sweatt JD
  (2001) Nat Rev Neurosci 2: 461-74
• Control of pancreas and liver gene expression by HNF transcription factors.
  Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA
  (2004) Science 303: 1378-81
• ATR and ATRIP: partners in checkpoint signaling.
  Cortez D, Guntuku S, Qin J, Elledge SJ
  (2001) Science 294: 1713-6
• Interleukin-4 and interleukin-13 signaling connections maps.
  Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD
  (2003) Science 300: 1527-8
• Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.
  Gould KL, Moreno S, Tonks NK, Nurse P
  (1990) Science 250: 1573-6
• A rising StAR: an essential role in cholesterol transport.
  Waterman MR
  (1995) Science 267: 1780-1
• A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
  Westphal RS, Anderson KA, Means AR, Wadzinski BE
  (1998) Science 280: 1258-61
• Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer.
  Liu J, Ghanim M, Xue L, Brown CD, Iossifov I, Angeletti C, Hua S, Nègre N, Ludwig M, Stricker T, Al-Ahmadie HA, Tretiakova M, Camp RL, Perera-Alberto M, Rimm DL, Xu T, Rzhetsky A, White KP
  (2009) Science 323: 1218-22
• The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
  Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB
  (2003) Nat Med 9: 220-4
• TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
  Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N
  (2006) Nat Med 12: 107-13
• Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
  Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
  (2007) Nat Med 13: 1193-202
• Inhibition of RhoA by p120 catenin.
  Anastasiadis PZ, Moon SY, Thoreson MA, Mariner DJ, Crawford HC, Zheng Y, Reynolds AB
  (2000) Nat Cell Biol 2: 637-44
• Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts.
  Salic A, Lee E, Mayer L, Kirschner MW
  (2000) Mol Cell 5: 523-32
• Localization, macromolecular associations, and function of the small heat shock-related protein HSP20 in rat heart.
  Pipkin W, Johnson JA, Creazzo TL, Burch J, Komalavilas P, Brophy C
  (2003) Circulation 107: 469-76
• Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma.
  Khatri JJ, Johnson C, Magid R, Lessner SM, Laude KM, Dikalov SI, Harrison DG, Sung HJ, Rong Y, Galis ZS
  (2004) Circulation 109: 520-5
• Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland.
  Davis MA, Reynolds AB
  (2006) Dev Cell 10: 21-31
• Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.
  Moon KH, Kim HT, Lee D, Rao MB, Levine EM, Lim DS, Kim JW
  (2018) Dev Cell 44: 13-28.e3
• Lipid research picks up speed on the slopes of Taos.
  Field SJ, Lamia KA, Rameh LE, Cantley LC
  (2002) Dev Cell 2: 407-10
• Phospho-regulation of the Cdc14/Clp1 phosphatase delays late mitotic events in S. pombe.
  Wolfe BA, McDonald WH, Yates JR, Gould KL
  (2006) Dev Cell 11: 423-30