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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Liver Neoplasms are shown below. Double-click or tap a node for more information.
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- M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.
De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL
(1995) Nat Genet 11: 447-9 - Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma.
Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu, Cancer Genome Atlas Research Network
(2017) Cell 169: 1327-1341.e23 - Acetate dependence of tumors.
Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP
(2014) Cell 159: 1591-602 - Hdac3 is essential for the maintenance of chromatin structure and genome stability.
Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW
(2010) Cancer Cell 18: 436-47 - Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
(2007) Nat Med 13: 1193-202 - Hodgkin's lymphoma: Richter's transformation of chronic lymphocytic leukemia involving the liver.
Reddy N, Thompson-Arildsen MA
(2010) J Clin Oncol 28: e543-4 - Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: a University of Chicago Phase II Consortium study.
Stadler WM, Vogelzang NJ, Amato R, Sosman J, Taber D, Liebowitz D, Vokes EE
(2000) J Clin Oncol 18: 371-5 - Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma.
O'Neil BH, Goff LW, Kauh JS, Strosberg JR, Bekaii-Saab TS, Lee RM, Kazi A, Moore DT, Learoyd M, Lush RM, Sebti SM, Sullivan DM
(2011) J Clin Oncol 29: 2350-6 - Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma.
Sahasrabuddhe VV, Gunja MZ, Graubard BI, Trabert B, Schwartz LM, Park Y, Hollenbeck AR, Freedman ND, McGlynn KA
(2012) J Natl Cancer Inst 104: 1808-14 - Statin use and risk of primary liver cancer in the Clinical Practice Research Datalink.
McGlynn KA, Hagberg K, Chen J, Graubard BI, London WT, Jick S, Sahasrabuddhe VV
(2015) J Natl Cancer Inst 107: - Vitamin intake and liver cancer risk: a report from two cohort studies in China.
Zhang W, Shu XO, Li H, Yang G, Cai H, Ji BT, Gao J, Gao YT, Zheng W, Xiang YB
(2012) J Natl Cancer Inst 104: 1173-81 - Cancer cachexia: getting to the heart of the matter.
Groarke JD, Cheng S, Jones LW, Moslehi J
(2019) Eur Heart J 40: e17-e19 - Cumulative Incidence of Cancer Among Persons With HIV in North America: A Cohort Study.
Silverberg MJ, Lau B, Achenbach CJ, Jing Y, Althoff KN, D'Souza G, Engels EA, Hessol NA, Brooks JT, Burchell AN, Gill MJ, Goedert JJ, Hogg R, Horberg MA, Kirk GD, Kitahata MM, Korthuis PT, Mathews WC, Mayor A, Modur SP, Napravnik S, Novak RM, Patel P, Rachlis AR, Sterling TR, Willig JH, Justice AC, Moore RD, Dubrow R, North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS
(2015) Ann Intern Med 163: 507-18 - p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.
Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, Volinia S, Pineau P, Marchio A, Palatini J, Suh SS, Alder H, Liu CG, Dejean A, Croce CM
(2011) J Exp Med 208: 875-83 - Diverse expression of ErbB receptor proteins during rat liver development and regeneration.
Carver RS, Stevenson MC, Scheving LA, Russell WE
(2002) Gastroenterology 123: 2017-27 - Antimetastatic role of Smad4 signaling in colorectal cancer.
Zhang B, Halder SK, Kashikar ND, Cho YJ, Datta A, Gorden DL, Datta PK
(2010) Gastroenterology 138: 969-80.e1-3 - Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML
(2012) Gastroenterology 143: 787-798.e13 - HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.
Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglim PP, Finnell RH, Caballería J, Laird-Offringa IA, Gorospe M, Lu SC, Mato JM, Martínez-Chantar ML
(2010) Gastroenterology 138: 1943-53 - Acute reactant cytokines and neutrophil adhesion after warm ischemia in cirrhotic and noncirrhotic human livers.
Clavien PA, Camargo CA, Gorczynski R, Washington MK, Levy GA, Langer B, Greig PD
(1996) Hepatology 23: 1456-63 - Chemoimmunotherapy of experimental hepatic metastases.
Williams DL, Sherwood ER, McNamee RB, Jones EL, Browder IW, Di Luzio NR
(1987) Hepatology 7: 1296-304 - Therapeutic efficacy of glucan in a murine model of hepatic metastatic disease.
Williams DL, Sherwood ER, McNamee RB, Jones EL, Di Luzio NR
(1985) Hepatology 5: 198-206 - Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography.
Masuzaki R, Tateishi R, Yoshida H, Goto E, Sato T, Ohki T, Imamura J, Goto T, Kanai F, Kato N, Ikeda H, Shiina S, Kawabe T, Omata M
(2009) Hepatology 49: 1954-61 - Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevila A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM
(2008) Hepatology 47: 1191-9 - Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma.
Yoshida S, Kornek M, Ikenaga N, Schmelzle M, Masuzaki R, Csizmadia E, Wu Y, Robson SC, Schuppan D
(2013) Hepatology 58: 1667-80 - Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH.
Ohki T, Tateishi R, Shiina S, Goto E, Sato T, Nakagawa H, Masuzaki R, Goto T, Hamamura K, Kanai F, Yoshida H, Kawabe T, Omata M
(2009) Gut 58: 839-44 - Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence.
Soroida Y, Ohkawa R, Nakagawa H, Satoh Y, Yoshida H, Kinoshita H, Tateishi R, Masuzaki R, Enooku K, Shiina S, Sato T, Obi S, Hoshino T, Nagatomo R, Okubo S, Yokota H, Koike K, Yatomi Y, Ikeda H
(2012) J Hepatol 57: 330-6 - Antiglucocorticoid activity of hepatocyte nuclear factor-6.
Pierreux CE, Stafford J, Demonte D, Scott DK, Vandenhaute J, O'Brien RM, Granner DK, Rousseau GG, Lemaigre FP
(1999) Proc Natl Acad Sci U S A 96: 8961-6 - Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.
Haase VH, Glickman JN, Socolovsky M, Jaenisch R
(2001) Proc Natl Acad Sci U S A 98: 1583-8 - Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.
Meynard D, Vaja V, Sun CC, Corradini E, Chen S, López-Otín C, Grgurevic L, Hong CC, Stirnberg M, Gütschow M, Vukicevic S, Babitt JL, Lin HY
(2011) Blood 118: 747-56 - Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging.
Deane NG, Lee H, Hamaamen J, Ruley A, Washington MK, LaFleur B, Thorgeirsson SS, Price R, Beauchamp RD
(2004) Cancer Res 64: 1315-22 - Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress.
Kopetz S, Lesslie DP, Dallas NA, Park SI, Johnson M, Parikh NU, Kim MP, Abbruzzese JL, Ellis LM, Chandra J, Gallick GE
(2009) Cancer Res 69: 3842-9 - Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction.
Nicoud IB, Jones CM, Pierce JM, Earl TM, Matrisian LM, Chari RS, Gorden DL
(2007) Cancer Res 67: 2720-8 - IL4 receptor ILR4α regulates metastatic colonization by mammary tumors through multiple signaling pathways.
Venmar KT, Carter KJ, Hwang DG, Dozier EA, Fingleton B
(2014) Cancer Res 74: 4329-40 - Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.
Aslakson CJ, Miller FR
(1992) Cancer Res 52: 1399-405 - Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice.
Deane NG, Parker MA, Aramandla R, Diehl L, Lee WJ, Washington MK, Nanney LB, Shyr Y, Beauchamp RD
(2001) Cancer Res 61: 5389-95 - Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice.
Reinmuth N, Liu W, Ahmad SA, Fan F, Stoeltzing O, Parikh AA, Bucana CD, Gallick GE, Nickols MA, Westlin WF, Ellis LM
(2003) Cancer Res 63: 2079-87 - Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors.
Stoeltzing O, Ahmad SA, Liu W, McCarty MF, Wey JS, Parikh AA, Fan F, Reinmuth N, Kawaguchi M, Bucana CD, Ellis LM
(2003) Cancer Res 63: 3370-7 - In vivo intracellular signaling as a marker of antiangiogenic activity.
Solorzano CC, Jung YD, Bucana CD, McConkey DJ, Gallick GE, McMahon G, Ellis LM
(2001) Cancer Res 61: 7048-51 - Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase.
Cotten M, Bresnahan D, Thompson S, Sealy L, Chalkley R
(1986) Nucleic Acids Res 14: 3671-86 - Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene.
Ebert DH, Bischof LJ, Streeper RS, Chapman SC, Svitek CA, Goldman JK, Mathews CE, Leiter EH, Hutton JC, O'Brien RM
(1999) Diabetes 48: 543-51
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