Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR (2017) Nature 551: 464-471 Multiplex genome engineering using CRISPR/Cas systems. Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F (2013) Science 339: 819-23 DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Lee S, Jung SR, Heo K, Byl JA, Deweese JE, Osheroff N, Hohng S (2012) Proc Natl Acad Sci U S A 109: 2925-30 The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I. Gentry AC, Juul S, Veigaard C, Knudsen BR, Osheroff N (2011) Nucleic Acids Res 39: 1014-22 The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Deweese JE, Osheroff N (2009) Nucleic Acids Res 37: 738-48 Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Pitts SL, Liou GF, Mitchenall LA, Burgin AB, Maxwell A, Neuman KC, Osheroff N (2011) Nucleic Acids Res 39: 4808-17 Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage. Deweese JE, Burgin AB, Osheroff N (2008) Nucleic Acids Res 36: 4883-93 A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Mussolino C, Morbitzer R, Lütge F, Dannemann N, Lahaye T, Cathomen T (2011) Nucleic Acids Res 39: 9283-93 Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance. Aldred KJ, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N (2013) Nucleic Acids Res 41: 4628-39 Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. Aldred KJ, Schwanz HA, Li G, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N (2013) ACS Chem Biol 8: 2660-8 Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Bender RP, Osheroff N (2007) Chem Res Toxicol 20: 975-81 Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases. Timmel MA, Byl JA, Osheroff N (2013) Chem Res Toxicol 26: 622-8 Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα. Gordon ON, Luis PB, Ashley RE, Osheroff N, Schneider C (2015) Chem Res Toxicol 28: 989-96 The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage. Wani TH, Chakrabarty A, Shibata N, Yamazaki H, Guengerich FP, Chowdhury G (2017) Chem Res Toxicol 30: 1622-1628 Synthetic prodigiosenes and the influence of C-ring substitution on DNA cleavage, transmembrane chloride transport and basicity. Rastogi S, Marchal E, Uddin I, Groves B, Colpitts J, McFarland SA, Davis JT, Thompson A (2013) Org Biomol Chem 11: 3834-45 Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex. Pitts SL, Jablonksy MJ, Duca M, Dauzonne D, Monneret C, Arimondo PB, Anklin C, Graves DE, Osheroff N (2011) Biochemistry 50: 5058-66 Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Gentry AC, Pitts SL, Jablonsky MJ, Bailly C, Graves DE, Osheroff N (2011) Biochemistry 50: 3240-9 Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Bender RP, Ham AJ, Osheroff N (2007) Biochemistry 46: 2856-64 Oxidative metabolites of curcumin poison human type II topoisomerases. Ketron AC, Gordon ON, Schneider C, Osheroff N (2013) Biochemistry 52: 221-7 Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions. Ketron AC, Denny WA, Graves DE, Osheroff N (2012) Biochemistry 51: 1730-9
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.