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•  Ethan Lee

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Publications

• Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling.
  Yang SH, Andl T, Grachtchouk V, Wang A, Liu J, Syu LJ, Ferris J, Wang TS, Glick AB, Millar SE, Dlugosz AA
  (2008) Nat Genet 40: 1130-5
• Wnt-beta-catenin signaling initiates taste papilla development.
  Liu F, Thirumangalathu S, Gallant NM, Yang SH, Stoick-Cooper CL, Reddy ST, Andl T, Taketo MM, Dlugosz AA, Moon RT, Barlow LA, Millar SE
  (2007) Nat Genet 39: 106-12
• Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells.
  Lippmann ES, Azarin SM, Kay JE, Nessler RA, Wilson HK, Al-Ahmad A, Palecek SP, Shusta EV
  (2012) Nat Biotechnol 30: 783-91
• Hairy math: insights into hair-follicle spacing and orientation.
  Stark J, Andl T, Millar SE
  (2007) Cell 128: 17-20
• A repeating amino acid motif shared by proteins with diverse cellular roles.
  Peifer M, Berg S, Reynolds AB
  (1994) Cell 76: 789-91
• lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling.
  Lu Y, Zhao X, Liu Q, Li C, Graves-Deal R, Cao Z, Singh B, Franklin JL, Wang J, Hu H, Wei T, Yang M, Yeatman TJ, Lee E, Saito-Diaz K, Hinger S, Patton JG, Chung CH, Emmrich S, Klusmann JH, Fan D, Coffey RJ
  (2017) Nat Med 23: 1331-1341
• Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts.
  Salic A, Lee E, Mayer L, Kirschner MW
  (2000) Mol Cell 5: 523-32
• Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
  Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E
  (2010) Nat Chem Biol 6: 829-36
• WNT signals are required for the initiation of hair follicle development.
  Andl T, Reddy ST, Gaddapara T, Millar SE
  (2002) Dev Cell 2: 643-53
• Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland.
  Davis MA, Reynolds AB
  (2006) Dev Cell 10: 21-31
• APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
  Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed Y, Lee E
  (2018) Dev Cell 44: 566-581.e8
• Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.
  Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R
  (2009) Dev Cell 17: 49-61
• SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity.
  Noah TK, Lo YH, Price A, Chen G, King E, Washington MK, Aronow BJ, Shroyer NF
  (2013) Gastroenterology 144: 1012-1023.e6
• Beta-catenin in the liver: an integrator of proliferation and metabolism?
  Scheving LA, Russell WE
  (2006) Gastroenterology 131: 1641-3
• The role of PPARgamma in colon cancer: is it as simple as APC?
  Peek RM
  (2003) Gastroenterology 125: 619-21
• Making Cancer Quiescent: SPDEF De-Cycles Beta-Catenin.
  Fingleton B
  (2017) Gastroenterology 153: 10-12
• TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
  Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Song X, Ulrich CM, Sasazuki T, Shirasawa S, Grady WM
  (2009) Gastroenterology 136: 1680-8.e7
• Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia.
  Nam KT, Lee HJ, Mok H, Romero-Gallo J, Crowe JE, Peek RM, Goldenring JR
  (2009) Gastroenterology 136: 1288-96
• β-Catenin and p120 mediate PPARδ-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia.
  Nagy TA, Wroblewski LE, Wang D, Piazuelo MB, Delgado A, Romero-Gallo J, Noto J, Israel DA, Ogden SR, Correa P, Cover TL, Peek RM
  (2011) Gastroenterology 141: 553-64
• Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.
  Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD
  (2012) Gastroenterology 142: 562-571.e2
• Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury.
  Volckaert T, Dill E, Campbell A, Tiozzo C, Majka S, Bellusci S, De Langhe SP
  (2011) J Clin Invest 121: 4409-19
• Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer.
  Dhawan P, Singh AB, Deane NG, No Y, Shiou SR, Schmidt C, Neff J, Washington MK, Beauchamp RD
  (2005) J Clin Invest 115: 1765-76
• β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin.
  Tanjore H, Degryse AL, Crossno PF, Xu XC, McConaha ME, Jones BR, Polosukhin VV, Bryant AJ, Cheng DS, Newcomb DC, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE
  (2013) Am J Respir Crit Care Med 187: 630-9
• p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells.
  Aono S, Nakagawa S, Reynolds AB, Takeichi M
  (1999) J Cell Biol 145: 551-62
• Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon.
  Lee E, Salic A, Kirschner MW
  (2001) J Cell Biol 154: 983-93
• Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis.
  Soutto M, Peng D, Katsha A, Chen Z, Piazuelo MB, Washington MK, Belkhiri A, Correa P, El-Rifai W
  (2015) Gut 64: 1028-39
• Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells.
  Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM
  (2015) Gut 64: 720-30
• Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer.
  Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden J, Dove WF, Threadgill DW, Yeatman TJ, Coffey RJ, Aronow BJ
  (2007) Genome Biol 8: R131
• Wnt pathway activation by ADP-ribosylation.
  Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, Ahmed Y
  (2016) Nat Commun 7: 11430
• N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.
  Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y
  (2013) Nat Commun 4: 1589
• LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
  Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E
  (2008) Proc Natl Acad Sci U S A 105: 8032-7
• Activation of beta-catenin by carcinogenic Helicobacter pylori.
  Franco AT, Israel DA, Washington MK, Krishna U, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Gaus K, O'Brien DP, Romero-Gallo J, Peek RM
  (2005) Proc Natl Acad Sci U S A 102: 10646-51
• Mutated beta-catenin evades a microRNA-dependent regulatory loop.
  Veronese A, Visone R, Consiglio J, Acunzo M, Lupini L, Kim T, Ferracin M, Lovat F, Miotto E, Balatti V, D'Abundo L, Gramantieri L, Bolondi L, Pekarsky Y, Perrotti D, Negrini M, Croce CM
  (2011) Proc Natl Acad Sci U S A 108: 4840-5
• Epithelial organization: new perspective on α-catenin from an ancient source.
  Reynolds AB
  (2011) Curr Biol 21: R430-2
• Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.
  Plisov S, Tsang M, Shi G, Boyle S, Yoshino K, Dunwoodie SL, Dawid IB, Shioda T, Perantoni AO, de Caestecker MP
  (2005) J Am Soc Nephrol 16: 1632-44
• Blocking TGF- and -Catenin Epithelial Crosstalk Exacerbates CKD.
  Nlandu-Khodo S, Neelisetty S, Phillips M, Manolopoulou M, Bhave G, May L, Clark PE, Yang H, Fogo AB, Harris RC, Taketo MM, Lee E, Gewin LS
  (2017) J Am Soc Nephrol 28: 3490-3503
• Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.
  Kim I, Ding T, Fu Y, Li C, Cui L, Li A, Lian P, Liang D, Wang DW, Guo C, Ma J, Zhao P, Coffey RJ, Zhan Q, Wu G
  (2009) J Am Soc Nephrol 20: 2556-69
• Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells.
  Shiou SR, Singh AB, Moorthy K, Datta PK, Washington MK, Beauchamp RD, Dhawan P
  (2007) Cancer Res 67: 1571-9
• p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells.
  Tomkova K, Belkhiri A, El-Rifai W, Zaika AI
  (2004) Cancer Res 64: 6390-3
• Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors.
  Franco AT, Johnston E, Krishna U, Yamaoka Y, Israel DA, Nagy TA, Wroblewski LE, Piazuelo MB, Correa P, Peek RM
  (2008) Cancer Res 68: 379-87