Keyword Connections

•  Boone Prentice
•  Claus Schneider
•  F. Guengerich

•  Ginger Milne
•  Jeffrey Spraggins
•  Jeremy Norris

•  Richard Caprioli
•  Romell Gletten
•  Trayambak Basak

Resources

• Eicosanoid Sub-Core

Communities

• Center for Innovative Technology
• Eicosanoid Core Lab
• Zinkel Lab

Publications

• Release of prostaglandin D2 into human airways during acute antigen challenge.
  Murray JJ, Tonnel AB, Brash AR, Roberts LJ, Gosset P, Workman R, Capron A, Oates JA
  (1986) N Engl J Med 315: 800-4
• MALDI imaging of lipid biochemistry in tissues by mass spectrometry.
  Berry KA, Hankin JA, Barkley RM, Spraggins JM, Caprioli RM, Murphy RC
  (2011) Chem Rev 111: 6491-512
• Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research.
  Norris JL, Caprioli RM
  (2013) Chem Rev 113: 2309-42
• Proteomic patterns of tumour subsets in non-small-cell lung cancer.
  Yanagisawa K, Shyr Y, Xu BJ, Massion PP, Larsen PH, White BC, Roberts JR, Edgerton M, Gonzalez A, Nadaf S, Moore JH, Caprioli RM, Carbone DP
  (2003) Lancet 362: 433-9
• Increased lipid peroxidation in patients with rhabdomyolysis.
  Holt S, Reeder B, Wilson M, Harvey S, Morrow JD, Roberts LJ, Moore K
  (1999) Lancet 353: 1241
• Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.
  Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T
  (2019) Nature 569: 131-135
• Molecular imaging by mass spectrometry--looking beyond classical histology.
  Schwamborn K, Caprioli RM
  (2010) Nat Rev Cancer 10: 639-46
• A cross-platform toolkit for mass spectrometry and proteomics.
  Chambers MC, Maclean B, Burke R, Amodei D, Ruderman DL, Neumann S, Gatto L, Fischer B, Pratt B, Egertson J, Hoff K, Kessner D, Tasman N, Shulman N, Frewen B, Baker TA, Brusniak MY, Paulse C, Creasy D, Flashner L, Kani K, Moulding C, Seymour SL, Nuwaysir LM, Lefebvre B, Kuhlmann F, Roark J, Rainer P, Detlev S, Hemenway T, Huhmer A, Langridge J, Connolly B, Chadick T, Holly K, Eckels J, Deutsch EW, Moritz RL, Katz JE, Agus DB, MacCoss M, Tabb DL, Mallick P
  (2012) Nat Biotechnol 30: 918-20
• Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.
  Addona TA, Abbatiello SE, Schilling B, Skates SJ, Mani DR, Bunk DM, Spiegelman CH, Zimmerman LJ, Ham AJ, Keshishian H, Hall SC, Allen S, Blackman RK, Borchers CH, Buck C, Cardasis HL, Cusack MP, Dodder NG, Gibson BW, Held JM, Hiltke T, Jackson A, Johansen EB, Kinsinger CR, Li J, Mesri M, Neubert TA, Niles RK, Pulsipher TC, Ransohoff D, Rodriguez H, Rudnick PA, Smith D, Tabb DL, Tegeler TJ, Variyath AM, Vega-Montoto LJ, Wahlander A, Waldemarson S, Wang M, Whiteaker JR, Zhao L, Anderson NL, Fisher SJ, Liebler DC, Paulovich AG, Regnier FE, Tempst P, Carr SA
  (2009) Nat Biotechnol 27: 633-41
• Direct analysis of protein complexes using mass spectrometry.
  Link AJ, Eng J, Schieltz DM, Carmack E, Mize GJ, Morris DR, Garvik BM, Yates JR
  (1999) Nat Biotechnol 17: 676-82
• The pros and cons of peptide-centric proteomics.
  Duncan MW, Aebersold R, Caprioli RM
  (2010) Nat Biotechnol 28: 659-64
• Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
  Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE
  (2017) Cell 170: 457-469.e13
• Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems.
  Murray E, Cho JH, Goodwin D, Ku T, Swaney J, Kim SY, Choi H, Park YG, Park JY, Hubbert A, McCue M, Vassallo S, Bakh N, Frosch MP, Wedeen VJ, Seung HS, Chung K
  (2015) Cell 163: 1500-14
• A sulfilimine bond identified in collagen IV.
  Vanacore R, Ham AJ, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG
  (2009) Science 325: 1230-4
• Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol.
  Joyce S, Woods AS, Yewdell JW, Bennink JR, De Silva AD, Boesteanu A, Balk SP, Cotter RJ, Brutkiewicz RR
  (1998) Science 279: 1541-4
• Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II.
  Karcher RL, Roland JT, Zappacosta F, Huddleston MJ, Annan RS, Carr SA, Gelfand VI
  (2001) Science 293: 1317-20
• Metal chelation and inhibition of bacterial growth in tissue abscesses.
  Corbin BD, Seeley EH, Raab A, Feldmann J, Miller MR, Torres VJ, Anderson KL, Dattilo BM, Dunman PM, Gerads R, Caprioli RM, Nacken W, Chazin WJ, Skaar EP
  (2008) Science 319: 962-5
• Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.
  Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ
  (1994) Science 265: 1580-2
• Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs.
  Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Varella-Garcia M, Franklin WA, Aronson SL, Su PF, Shyr Y, Camidge DR, Sequist LV, Glisson BS, Khuri FR, Garon EB, Pao W, Rudin C, Schiller J, Haura EB, Socinski M, Shirai K, Chen H, Giaccone G, Ladanyi M, Kugler K, Minna JD, Bunn PA
  (2014) JAMA 311: 1998-2006
• Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping.
  Van de Plas R, Yang J, Spraggins J, Caprioli RM
  (2015) Nat Methods 12: 366-72
• Evaluating protein interactions through cross-linking mass spectrometry.
  Tabb DL
  (2012) Nat Methods 9: 879-81
• Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction.
  Andersson M, Groseclose MR, Deutch AY, Caprioli RM
  (2008) Nat Methods 5: 101-8
• Shotgun mass spec goes independent.
  Liebler DC
  (2004) Nat Methods 1: 16-7
• Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging.
  Sinha TK, Khatib-Shahidi S, Yankeelov TE, Mapara K, Ehtesham M, Cornett DS, Dawant BM, Caprioli RM, Gore JC
  (2008) Nat Methods 5: 57-9
• MALDI imaging mass spectrometry: molecular snapshots of biochemical systems.
  Cornett DS, Reyzer ML, Chaurand P, Caprioli RM
  (2007) Nat Methods 4: 828-33
• Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.
  Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP
  (2016) Nat Med 22: 1330-1334
• Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
  Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM
  (2016) Nat Med 22: 497-505
• Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues.
  Stoeckli M, Chaurand P, Hallahan DE, Caprioli RM
  (2001) Nat Med 7: 493-6
• Metabolite profiles and the risk of developing diabetes.
  Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE
  (2011) Nat Med 17: 448-53
• Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers.
  Guix M, Granja Nde M, Meszoely I, Adkins TB, Wieman BM, Frierson KE, Sanchez V, Sanders ME, Grau AM, Mayer IA, Pestano G, Shyr Y, Muthuswamy S, Calvo B, Krontiras H, Krop IE, Kelley MC, Arteaga CL
  (2008) J Clin Oncol 26: 897-906
• In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
  Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O
  (2013) Cell Metab 17: 372-85
• Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: a multicohort cross-institutional study.
  Taguchi F, Solomon B, Gregorc V, Roder H, Gray R, Kasahara K, Nishio M, Brahmer J, Spreafico A, Ludovini V, Massion PP, Dziadziuszko R, Schiller J, Grigorieva J, Tsypin M, Hunsucker SW, Caprioli R, Duncan MW, Hirsch FR, Bunn PA, Carbone DP
  (2007) J Natl Cancer Inst 99: 838-46
• Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrometry.
  Chowdhury G, Guengerich FP
  (2008) Angew Chem Int Ed Engl 47: 381-4
• Working towards an exegesis for lipids in biology.
  Brown HA, Murphy RC
  (2009) Nat Chem Biol 5: 602-6
• Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.
  Wang J, Mouradov D, Wang X, Jorissen RN, Chambers MC, Zimmerman LJ, Vasaikar S, Love CG, Li S, Lowes K, Leuchowius KJ, Jousset H, Weinstock J, Yau C, Mariadason J, Shi Z, Ban Y, Chen X, Coffey RJC, Slebos RJC, Burgess AW, Liebler DC, Zhang B, Sieber OM
  (2017) Gastroenterology 153: 1082-1095
• Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.
  Nagathihalli NS, Castellanos JA, Shi C, Beesetty Y, Reyzer ML, Caprioli R, Chen X, Walsh AJ, Skala MC, Moses HL, Merchant NB
  (2015) Gastroenterology 149: 1932-1943.e9
• The metabolism of 3alpha, 7alpha, 12alpha-trihydorxy-5beta-cholestan-26-oic acid in two siblings with cholestasis due to intrahepatic bile duct anomalies. An apparent inborn error of cholic acid synthesis.
  Hanson RF, Isenberg JN, Williams GC, Hachey D, Szczepanik P, Klein PD, Sharp HL
  (1975) J Clin Invest 56: 577-87
• Discovering naturally processed antigenic determinants that confer protective T cell immunity.
  Gilchuk P, Spencer CT, Conant SB, Hill T, Gray JJ, Niu X, Zheng M, Erickson JJ, Boyd KL, McAfee KJ, Oseroff C, Hadrup SR, Bennink JR, Hildebrand W, Edwards KM, Crowe JE, Williams JV, Buus S, Sette A, Schumacher TN, Link AJ, Joyce S
  (2013) J Clin Invest 123: 1976-87