Circadian rhythms of superhelical status of DNA in cyanobacteria. Woelfle MA, Xu Y, Qin X, Johnson CH (2007) Proc Natl Acad Sci U S A 104: 18819-24 Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro. Ackerman P, Glover CV, Osheroff N (1985) Proc Natl Acad Sci U S A 82: 3164-8 The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I. Gentry AC, Juul S, Veigaard C, Knudsen BR, Osheroff N (2011) Nucleic Acids Res 39: 1014-22 Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal. Frøhlich RF, Veigaard C, Andersen FF, McClendon AK, Gentry AC, Andersen AH, Osheroff N, Stevnsner T, Knudsen BR (2007) Nucleic Acids Res 35: 6170-80 Catalytic function of DNA topoisomerase II. Osheroff N, Zechiedrich EL, Gale KC (1991) Bioessays 13: 269-73 Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation. Shapiro PS, Whalen AM, Tolwinski NS, Wilsbacher J, Froelich-Ammon SJ, Garcia M, Osheroff N, Ahn NG (1999) Mol Cell Biol 19: 3551-60 Restriction-modification system differences in Helicobacter pylori are a barrier to interstrain plasmid transfer. Ando T, Xu Q, Torres M, Kusugami K, Israel DA, Blaser MJ (2000) Mol Microbiol 37: 1052-65 Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα. Seol Y, Gentry AC, Osheroff N, Neuman KC (2013) J Biol Chem 288: 13695-703 Eukaryotic topoisomerase II. Characterization of enzyme turnover. Osheroff N (1986) J Biol Chem 261: 9944-50 DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA. Osheroff N, Shelton ER, Brutlag DL (1983) J Biol Chem 258: 9536-43 Communication between the ATPase and cleavage/religation domains of human topoisomerase IIalpha. Bjergbaek L, Kingma P, Nielsen IS, Wang Y, Westergaard O, Osheroff N, Andersen AH (2000) J Biol Chem 275: 13041-8 Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. McClendon AK, Rodriguez AC, Osheroff N (2005) J Biol Chem 280: 39337-45 Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme. Corbett AH, Hong D, Osheroff N (1993) J Biol Chem 268: 14394-8 Catabolite activator protein-induced DNA bending in transcription initiation. Zinkel SS, Crothers DM (1991) J Mol Biol 219: 201-15 DNA topoisomerase II, genotoxicity, and cancer. McClendon AK, Osheroff N (2007) Mutat Res 623: 83-97 Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Bender RP, Osheroff N (2007) Chem Res Toxicol 20: 975-81 DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition. Fortune JM, Velea L, Graves DE, Utsugi T, Yamada Y, Osheroff N (1999) Biochemistry 38: 15580-6 Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs. Elsea SH, Westergaard M, Burden DA, Lomenick JP, Osheroff N (1997) Biochemistry 36: 2919-24 The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs. McClendon AK, Osheroff N (2006) Biochemistry 45: 3040-50 Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes. McClendon AK, Dickey JS, Osheroff N (2006) Biochemistry 45: 11674-80 Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Baldwin EL, Byl JA, Osheroff N (2004) Biochemistry 43: 728-35 Covalent attachment of ethidium to DNA results in enhanced topoisomerase II-mediated DNA cleavage. Marx G, Zhou H, Graves DE, Osheroff N (1997) Biochemistry 36: 15884-91 DNA ligation catalyzed by human topoisomerase II alpha. Bromberg KD, Vélez-Cruz R, Burgin AB, Osheroff N (2004) Biochemistry 43: 13416-23 Site-specific DNA cleavage by Chlorella virus topoisomerase II. Fortune JM, Dickey JS, Lavrukhin OV, Van Etten JL, Lloyd RS, Osheroff N (2002) Biochemistry 41: 11761-9 DNA cleavage and religation by human topoisomerase II alpha at high temperature. Bromberg KD, Osheroff N (2001) Biochemistry 40: 8410-8
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