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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Carrier Proteins are shown below. Double-click or tap a node for more information.
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- Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency.
Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D
(2000) N Engl J Med 342: 541-9 - Death, destruction, and the proteasome.
Tansey WP
(2004) N Engl J Med 351: 393-4 - Solution structure of the cyclosporin A/cyclophilin complex by NMR.
Thériault Y, Logan TM, Meadows R, Yu L, Olejniczak ET, Holzman TF, Simmer RL, Fesik SW
(1993) Nature 361: 88-91 - An RNA-export mediator with an essential nuclear export signal.
Murphy R, Wente SR
(1996) Nature 383: 357-60 - Cloning and expression of a functional serotonin transporter from rat brain.
Blakely RD, Berson HE, Fremeau RT, Caron MG, Peek MM, Prince HK, Bradley CC
(1991) Nature 354: 66-70 - Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW
(2000) Nature 408: 1004-8 - Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis.
Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ
(1999) Nature 400: 886-91 - Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter.
Pacholczyk T, Blakely RD, Amara SG
(1991) Nature 350: 350-4 - Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fèvre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD
(2012) Nature 488: 49-56 - NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Eberstadt M, Huang B, Chen Z, Meadows RP, Ng SC, Zheng L, Lenardo MJ, Fesik SW
(1998) Nature 392: 941-5 - Leptin regulation of bone resorption by the sympathetic nervous system and CART.
Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G
(2005) Nature 434: 514-20 - Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.
Hemann MT, Bric A, Teruya-Feldstein J, Herbst A, Nilsson JA, Cordon-Cardo C, Cleveland JL, Tansey WP, Lowe SW
(2005) Nature 436: 807-11 - Immunology: TRIM5 does double duty.
Aiken C, Joyce S
(2011) Nature 472: 305-6 - Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A, Välimäki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR, Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB, Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M, Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP
(2012) Nature 482: 98-102 - ATR: an essential regulator of genome integrity.
Cimprich KA, Cortez D
(2008) Nat Rev Mol Cell Biol 9: 616-27 - Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter.
Delpire E, Lu J, England R, Dull C, Thorne T
(1999) Nat Genet 22: 192-5 - Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.
Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Hills M, Jarosz M, Drury S, Canisius S, Bolla MK, Dennis J, Wang Q, Hopper JL, Southey MC, Broeks A, Schmidt MK, Lophatananon A, Muir K, Beckmann MW, Fasching PA, Dos-Santos-Silva I, Peto J, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Guénel P, Truong T, Bojesen SE, Flyger H, González-Neira A, Perez JI, Anton-Culver H, Eunjung L, Arndt V, Brenner H, Meindl A, Schmutzler RK, Brauch H, Hamann U, Aittomäki K, Blomqvist C, Ito H, Matsuo K, Bogdanova N, Dörk T, Lindblom A, Margolin S, Kosma VM, Mannermaa A, Tseng CC, Wu AH, Lambrechts D, Wildiers H, Chang-Claude J, Rudolph A, Peterlongo P, Radice P, Olson JE, Giles GG, Milne RL, Haiman CA, Henderson BE, Goldberg MS, Teo SH, Yip CH, Nord S, Borresen-Dale AL, Kristensen V, Long J, Zheng W, Pylkäs K, Winqvist R, Andrulis IL, Knight JA, Devilee P, Seynaeve C, Figueroa J, Sherman ME, Czene K, Darabi H, Hollestelle A, van den Ouweland AM, Humphreys K, Gao YT, Shu XO, Cox A, Cross SS, Blot W, Cai Q, Ghoussaini M, Perkins BJ, Shah M, Choi JY, Kang D, Lee SC, Hartman M, Kabisch M, Torres D, Jakubowska A, Lubinski J, Brennan P, Sangrajrang S, Ambrosone CB, Toland AE, Shen CY, Wu PE, Orr N, Swerdlow A, McGuffog L, Healey S, Lee A, Kapuscinski M, John EM, Terry MB, Daly MB, Goldgar DE, Buys SS, Janavicius R, Tihomirova L, Tung N, Dorfling CM, van Rensburg EJ, Neuhausen SL, Ejlertsen B, Hansen TV, Osorio A, Benitez J, Rando R, Weitzel JN, Bonanni B, Peissel B, Manoukian S, Papi L, Ottini L, Konstantopoulou I, Apostolou P, Garber J, Rashid MU, Frost D, EMBRACE, Izatt L, Ellis S, Godwin AK, Arnold N, Niederacher D, Rhiem K, Bogdanova-Markov N, Sagne C, Stoppa-Lyonnet D, Damiola F, GEMO Study Collaborators, Sinilnikova OM, Mazoyer S, Isaacs C, Claes KB, De Leeneer K, de la Hoya M, Caldes T, Nevanlinna H, Khan S, Mensenkamp AR, HEBON, Hooning MJ, Rookus MA, Kwong A, Olah E, Diez O, Brunet J, Pujana MA, Gronwald J, Huzarski T, Barkardottir RB, Laframboise R, Soucy P, Montagna M, Agata S, Teixeira MR, kConFab Investigators, Park SK, Lindor N, Couch FJ, Tischkowitz M, Foretova L, Vijai J, Offit K, Singer CF, Rappaport C, Phelan CM, Greene MH, Mai PL, Rennert G, Imyanitov EN, Hulick PJ, Phillips KA, Piedmonte M, Mulligan AM, Glendon G, Bojesen A, Thomassen M, Caligo MA, Yoon SY, Friedman E, Laitman Y, Borg A, von Wachenfeldt A, Ehrencrona H, Rantala J, Olopade OI, Ganz PA, Nussbaum RL, Gayther SA, Nathanson KL, Domchek SM, Arun BK, Mitchell G, Karlan BY, Lester J, Maskarinec G, Woolcott C, Scott C, Stone J, Apicella C, Tamimi R, Luben R, Khaw KT, Helland Å, Haakensen V, Dowsett M, Pharoah PD, Simard J, Hall P, García-Closas M, Vachon C, Chenevix-Trench G, Antoniou AC, Easton DF, Edwards SL
(2016) Nat Genet 48: 374-86 - Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus.
Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S
(1993) Cell 73: 1041-9 - The mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translation.
Bolger TA, Folkmann AW, Tran EJ, Wente SR
(2008) Cell 134: 624-33 - Evidence for a differential avidity model of T cell selection in the thymus.
Ashton-Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher HP, Zinkernagel RM, Tonegawa S
(1994) Cell 76: 651-63 - A role for proapoptotic BID in the DNA-damage response.
Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross A, Korsmeyer SJ
(2005) Cell 122: 579-91 - Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion.
Crawley SW, Shifrin DA, Grega-Larson NE, McConnell RE, Benesh AE, Mao S, Zheng Y, Zheng QY, Nam KT, Millis BA, Kachar B, Tyska MJ
(2014) Cell 157: 433-446 - From silencing to gene expression: real-time analysis in single cells.
Janicki SM, Tsukamoto T, Salghetti SE, Tansey WP, Sachidanandam R, Prasanth KV, Ried T, Shav-Tal Y, Bertrand E, Singer RH, Spector DL
(2004) Cell 116: 683-98 - ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity.
Brown HA, Gutowski S, Moomaw CR, Slaughter C, Sternweis PC
(1993) Cell 75: 1137-44 - Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A.
Mudryj M, Devoto SH, Hiebert SW, Hunter T, Pines J, Nevins JR
(1991) Cell 65: 1243-53 - Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.
Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS
(2000) Cell 103: 583-94 - Structural basis for the inhibition of caspase-3 by XIAP.
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS
(2001) Cell 104: 791-800 - The E2F transcription factor is a cellular target for the RB protein.
Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR
(1991) Cell 65: 1053-61 - Gatekeepers of the nucleus.
Wente SR
(2000) Science 288: 1374-7 - Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants.
Ramamoorthy S, Blakely RD
(1999) Science 285: 763-6 - A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation.
Miller MA, Nguyen VQ, Lee MH, Kosinski M, Schedl T, Caprioli RM, Greenstein D
(2001) Science 291: 2144-7 - Allosteric activators of glucokinase: potential role in diabetes therapy.
Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF
(2003) Science 301: 370-3 - A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE, Aman MJ, Dye JM, Lai JR, Chandran K
(2016) Science 354: 350-354 - Discovering high-affinity ligands for proteins: SAR by NMR.
Shuker SB, Hajduk PJ, Meadows RP, Fesik SW
(1996) Science 274: 1531-4 - Structural biology. Controlling the caspases.
Fesik SW, Shi Y
(2001) Science 294: 1477-8 - Isotope-edited NMR of cyclosporin A bound to cyclophilin: evidence for a trans 9,10 amide bond.
Fesik SW, Gampe RT, Holzman TF, Egan DA, Edalji R, Luly JR, Simmer R, Helfrich R, Kishore V, Rich DH
(1990) Science 250: 1406-9 - Neurobiology. Dopamine's reversal of fortune.
Blakely RD
(2001) Science 293: 2407-9 - A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
York JD, Odom AR, Murphy R, Ives EB, Wente SR
(1999) Science 285: 96-100 - RSY-1 is a local inhibitor of presynaptic assembly in C. elegans.
Patel MR, Shen K
(2009) Science 323: 1500-3 - The roles of retinoids in vertebrate development.
Means AL, Gudas LJ
(1995) Annu Rev Biochem 64: 201-33
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