Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease. Folkmann AW, Collier SE, Zhan X, Aditi , Ohi MD, Wente SR (2013) Cell 155: 582-93 The mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translation. Bolger TA, Folkmann AW, Tran EJ, Wente SR (2008) Cell 134: 624-33 Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export. Alcázar-Román AR, Tran EJ, Guo S, Wente SR (2006) Nat Cell Biol 8: 711-6 The DEAD-box protein Dbp5 controls mRNA export by triggering specific RNA:protein remodeling events. Tran EJ, Zhou Y, Corbett AH, Wente SR (2007) Mol Cell 28: 850-9 The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1. Hodge CA, Tran EJ, Noble KN, Alcazar-Roman AR, Ben-Yishay R, Scarcelli JJ, Folkmann AW, Shav-Tal Y, Wente SR, Cole CN (2011) Genes Dev 25: 1052-64 The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1. Noble KN, Tran EJ, Alcázar-Román AR, Hodge CA, Cole CN, Wente SR (2011) Genes Dev 25: 1065-77 An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export. Kendirgi F, Barry DM, Griffis ER, Powers MA, Wente SR (2003) J Cell Biol 160: 1029-40 Nuclear mRNA export requires specific FG nucleoporins for translocation through the nuclear pore complex. Terry LJ, Wente SR (2007) J Cell Biol 178: 1121-32 Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis. Kaneb HM, Folkmann AW, Belzil VV, Jao LE, Leblond CS, Girard SL, Daoud H, Noreau A, Rochefort D, Hince P, Szuto A, Levert A, Vidal S, André-Guimont C, Camu W, Bouchard JP, Dupré N, Rouleau GA, Wente SR, Dion PA (2015) Hum Mol Genet 24: 1363-73 The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155. Rayala HJ, Kendirgi F, Barry DM, Majerus PW, Wente SR (2004) Mol Cell Proteomics 3: 145-55 A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization. Jao LE, Appel B, Wente SR (2012) Development 139: 1316-26 Regulation of alternative splicing by SRrp86 and its interacting proteins. Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003) Mol Cell Biol 23: 7437-47 The mitogen-activated protein kinase Slt2 regulates nuclear retention of non-heat shock mRNAs during heat shock-induced stress. Carmody SR, Tran EJ, Apponi LH, Corbett AH, Wente SR (2010) Mol Cell Biol 30: 5168-79 Nup42 and IP coordinate Gle1 stimulation of Dbp5/DDX19B for mRNA export in yeast and human cells. Adams RL, Mason AC, Glass L, Aditi , Wente SR (2017) Traffic 18: 776-790 The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex. Strawn LA, Shen T, Wente SR (2001) J Biol Chem 276: 6445-52 Gle1 is a multifunctional DEAD-box protein regulator that modulates Ded1 in translation initiation. Bolger TA, Wente SR (2011) J Biol Chem 286: 39750-9 Recognition of polyadenosine RNA by the zinc finger domain of nuclear poly(A) RNA-binding protein 2 (Nab2) is required for correct mRNA 3'-end formation. Kelly SM, Leung SW, Apponi LH, Bramley AM, Tran EJ, Chekanova JA, Wente SR, Corbett AH (2010) J Biol Chem 285: 26022-32 Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function. Suntharalingam M, Alcázar-Román AR, Wente SR (2004) J Biol Chem 279: 35384-91 Control of mRNA export and translation termination by inositol hexakisphosphate requires specific interaction with Gle1. Alcázar-Román AR, Bolger TA, Wente SR (2010) J Biol Chem 285: 16683-92 Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA. Kendirgi F, Rexer DJ, Alcázar-Román AR, Onishko HM, Wente SR (2005) Mol Biol Cell 16: 4304-15 Cytoplasmic hGle1A regulates stress granules by modulation of translation. Aditi , Folkmann AW, Wente SR (2015) Mol Biol Cell 26: 1476-90 A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. Jao LE, Akef A, Wente SR (2017) Mol Biol Cell 28: 120-127 GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function. Murphy R, Watkins JL, Wente SR (1996) Mol Biol Cell 7: 1921-37 Nucleoporin FG domains facilitate mRNP remodeling at the cytoplasmic face of the nuclear pore complex. Adams RL, Terry LJ, Wente SR (2014) Genetics 197: 1213-24
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