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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to DNA Topoisomerases, Type II are shown below. Double-click or tap a node for more information.
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- Anthracyclines and heart failure.
Sawyer DB
(2013) N Engl J Med 368: 1154-6 - DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A, Walz C, Wiemels JL, Segal MR, Adès L, Blair IA, Osheroff N, Peniket AJ, Lafage-Pochitaloff M, Cross NC, Chomienne C, Solomon E, Fenaux P, Grimwade D
(2005) N Engl J Med 352: 1529-38 - Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers.
Zechiedrich EL, Osheroff N
(1990) EMBO J 9: 4555-62 - Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation.
Lovett BD, Lo Nigro L, Rappaport EF, Blair IA, Osheroff N, Zheng N, Megonigal MD, Williams WR, Nowell PC, Felix CA
(2001) Proc Natl Acad Sci U S A 98: 9802-7 - DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA.
Lee S, Jung SR, Heo K, Byl JA, Deweese JE, Osheroff N, Hohng S
(2012) Proc Natl Acad Sci U S A 109: 2925-30 - DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution.
Durrieu F, Samejima K, Fortune JM, Kandels-Lewis S, Osheroff N, Earnshaw WC
(2000) Curr Biol 10: 923-6 - Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/religation and sensitivity to the antineoplastic drugs etoposide and 4'-(9-acridinylamino)methane-sulfon-m-anisidide.
DeVore RF, Corbett AH, Osheroff N
(1992) Cancer Res 52: 2156-61 - Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II.
Baldwin EL, Berger AC, Corbett AH, Osheroff N
(2005) Nucleic Acids Res 33: 1021-30 - Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate.
Morrison C, Henzing AJ, Jensen ON, Osheroff N, Dodson H, Kandels-Lewis SE, Adams RR, Earnshaw WC
(2002) Nucleic Acids Res 30: 5318-27 - Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions.
Sabourin M, Osheroff N
(2000) Nucleic Acids Res 28: 1947-54 - Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.
Sabourin M, Nitiss JL, Nitiss KC, Tatebayashi K, Ikeda H, Osheroff N
(2003) Nucleic Acids Res 31: 4373-84 - Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.
Deweese JE, Burgin AB, Osheroff N
(2008) Nucleic Acids Res 36: 4883-93 - The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing.
Deweese JE, Osheroff N
(2009) Nucleic Acids Res 37: 738-48 - Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification.
Hardin AH, Sarkar SK, Seol Y, Liou GF, Osheroff N, Neuman KC
(2011) Nucleic Acids Res 39: 5729-43 - Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides.
Duca M, Guianvarc'h D, Oussedik K, Halby L, Garbesi A, Dauzonne D, Monneret C, Osheroff N, Giovannangeli C, Arimondo PB
(2006) Nucleic Acids Res 34: 1900-11 - Biochemical basis for the interactions of type I and type II topoisomerases with DNA.
Osheroff N
(1989) Pharmacol Ther 41: 223-41 - Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing.
Whitmarsh RJ, Saginario C, Zhuo Y, Hilgenfeld E, Rappaport EF, Megonigal MD, Carroll M, Liu M, Osheroff N, Cheung NK, Slater DJ, Ried T, Knutsen T, Blair IA, Felix CA
(2003) Oncogene 22: 8448-59 - MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site.
Slater DJ, Hilgenfeld E, Rappaport EF, Shah N, Meek RG, Williams WR, Lovett BD, Osheroff N, Autar RS, Ried T, Felix CA
(2002) Oncogene 21: 4706-14 - Coamplified and overexpressed genes at ERBB2 locus in gastric cancer.
Varis A, Zaika A, Puolakkainen P, Nagy B, Madrigal I, Kokkola A, Väyrynen A, Kärkkäinen P, Moskaluk C, El-Rifai W, Knuutila S
(2004) Int J Cancer 109: 548-53 - Biological characterization of MLN944: a potent DNA binding agent.
Sappal DS, McClendon AK, Fleming JA, Thoroddsen V, Connolly K, Reimer C, Blackman RK, Bulawa CE, Osheroff N, Charlton P, Rudolph-Owen LA
(2004) Mol Cancer Ther 3: 47-58 - Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.
Aldred KJ, Schwanz HA, Li G, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N
(2013) ACS Chem Biol 8: 2660-8 - Catalytic function of DNA topoisomerase II.
Osheroff N, Zechiedrich EL, Gale KC
(1991) Bioessays 13: 269-73 - Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.
Shapiro PS, Whalen AM, Tolwinski NS, Wilsbacher J, Froelich-Ammon SJ, Garcia M, Osheroff N, Ahn NG
(1999) Mol Cell Biol 19: 3551-60 - Topoisomerase poisons: harnessing the dark side of enzyme mechanism.
Froelich-Ammon SJ, Osheroff N
(1995) J Biol Chem 270: 21429-32 - A mutant yeast topoisomerase II (top2G437S) with differential sensitivity to anticancer drugs in the presence and absence of ATP.
Sabourin M, Byl JA, Hannah SE, Nitiss JL, Osheroff N
(1998) J Biol Chem 273: 29086-92 - DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.
Osheroff N, Shelton ER, Brutlag DL
(1983) J Biol Chem 258: 9536-43 - Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage.
Fortune JM, Osheroff N
(1998) J Biol Chem 273: 17643-50 - Topoisomerase IV catalysis and the mechanism of quinolone action.
Anderson VE, Gootz TD, Osheroff N
(1998) J Biol Chem 273: 17879-85 - DNA topoisomerase II from Drosophila melanogaster. Purification and physical characterization.
Shelton ER, Osheroff N, Brutlag DL
(1983) J Biol Chem 258: 9530-5 - In vitro evolution of preferred topoisomerase II DNA cleavage sites.
Burden DA, Osheroff N
(1999) J Biol Chem 274: 5227-35 - Eukaryotic topoisomerase II. Characterization of enzyme turnover.
Osheroff N
(1986) J Biol Chem 261: 9944-50 - Topoisomerase II-mediated DNA cleavage and religation in the absence of base pairing. Abasic lesions as a tool to dissect enzyme mechanism.
Kingma PS, Osheroff N
(1998) J Biol Chem 273: 17999-8002 - A two-drug model for etoposide action against human topoisomerase IIalpha.
Bromberg KD, Burgin AB, Osheroff N
(2003) J Biol Chem 278: 7406-12 - Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks.
McClendon AK, Rodriguez AC, Osheroff N
(2005) J Biol Chem 280: 39337-45 - Spontaneous DNA damage stimulates topoisomerase II-mediated DNA cleavage.
Kingma PS, Osheroff N
(1997) J Biol Chem 272: 7488-93 - Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism.
Bromberg KD, Hendricks C, Burgin AB, Osheroff N
(2002) J Biol Chem 277: 31201-6 - Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity.
Fortune JM, Lavrukhin OV, Gurnon JR, Van Etten JL, Lloyd RS, Osheroff N
(2001) J Biol Chem 276: 24401-8 - Base excision repair intermediates as topoisomerase II poisons.
Wilstermann AM, Osheroff N
(2001) J Biol Chem 276: 46290-6 - Communication between the ATPase and cleavage/religation domains of human topoisomerase IIalpha.
Bjergbaek L, Kingma P, Nielsen IS, Wang Y, Westergaard O, Osheroff N, Andersen AH
(2000) J Biol Chem 275: 13041-8 - Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries.
Anderson VE, Zaniewski RP, Kaczmarek FS, Gootz TD, Osheroff N
(1999) J Biol Chem 274: 35927-32
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