Characterization of human microsomal cytochrome P-450 enzymes. Guengerich FP (1989) Annu Rev Pharmacol Toxicol 29: 241-64 p53 has a direct apoptogenic role at the mitochondria. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM (2003) Mol Cell 11: 577-90 Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Shimada T, Guengerich FP (1989) Proc Natl Acad Sci U S A 86: 462-5 Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Morrow JD, Awad JA, Boss HJ, Blair IA, Roberts LJ (1992) Proc Natl Acad Sci U S A 89: 10721-5 Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes. Shimada T, Guengerich FP (1990) Cancer Res 50: 2036-43 Comparative metabolism of 1-, 2-, and 4-nitropyrene by human hepatic and pulmonary microsomes. Chae YH, Thomas T, Guengerich FP, Fu PP, El-Bayoumy K (1999) Cancer Res 59: 1473-80 Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene. Yun CH, Shimada T, Guengerich FP (1992) Cancer Res 52: 1868-74 Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. Shimada T, Iwasaki M, Martin MV, Guengerich FP (1989) Cancer Res 49: 3218-28 Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds. Shimada T, El-Bayoumy K, Upadhyaya P, Sutter TR, Guengerich FP, Yamazaki H (1997) Cancer Res 57: 4757-64 Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. Shimada T, Guengerich FP (1991) Cancer Res 51: 5284-91 Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Shimada T, Martin MV, Pruess-Schwartz D, Marnett LJ, Guengerich FP (1989) Cancer Res 49: 6304-12 A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Chun YJ, Kim S, Kim D, Lee SK, Guengerich FP (2001) Cancer Res 61: 8164-70 Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes. Guengerich FP, Shimada T, Yun CH, Yamazaki H, Raney KD, Thier R, Coles B, Harris TM (1994) Environ Health Perspect 102 Suppl 9: 49-53 Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug-Metabolizing Enzymes as a Response to Redox Alteration. Albertolle ME, Phan TTN, Pozzi A, Guengerich FP (2018) Mol Cell Proteomics 17: 889-900 16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. Huang Z, Guengerich FP, Kaminsky LS (1998) Carcinogenesis 19: 867-72 Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline). Yun CH, Shimada T, Guengerich FP (1992) Carcinogenesis 13: 217-22 In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. Guengerich FP, Kim DH (1990) Carcinogenesis 11: 2275-9 Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. Shimada T, Gillam EM, Sandhu P, Guo Z, Tukey RH, Guengerich FP (1994) Carcinogenesis 15: 2523-9 Microsomal cytochrome P450 and eicosanoid metabolism. Capdevila JH, Harris RC, Falck JR (2002) Cell Mol Life Sci 59: 780-9 Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅). Turlington M, Malosh C, Jacobs J, Manka JT, Noetzel MJ, Vinson PN, Jadhav S, Herman EJ, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martín-Martín ML, Tong HM, López S, MacDonald GJ, Steckler T, Daniels JS, Weaver CD, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Stauffer SR (2014) J Med Chem 57: 5620-37 Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW (2010) J Med Chem 53: 6706-19 Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor. Cheung YY, Yu H, Xu K, Zou B, Wu M, McManus OB, Li M, Lindsley CW, Hopkins CR (2012) J Med Chem 55: 6975-9 Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence. Sidique S, Dhanya RP, Sheffler DJ, Nickols HH, Yang L, Dahl R, Mangravita-Novo A, Smith LH, D'Souza MS, Semenova S, Conn PJ, Markou A, Cosford ND (2012) J Med Chem 55: 9434-45 Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4. Guengerich FP, Brian WR, Iwasaki M, Sari MA, Bäärnhielm C, Berntsson P (1991) J Med Chem 34: 1838-44 Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. Engers JL, Rodriguez AL, Konkol LC, Morrison RD, Thompson AD, Byers FW, Blobaum AL, Chang S, Venable DF, Loch MT, Niswender CM, Daniels JS, Jones CK, Conn PJ, Lindsley CW, Emmitte KA (2015) J Med Chem 58: 7485-500 Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR (2011) J Med Chem 54: 7639-47 Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW (2014) J Med Chem 57: 10192-7 Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. Cho HP, Garcia-Barrantes PM, Brogan JT, Hopkins CR, Niswender CM, Rodriguez AL, Venable DF, Morrison RD, Bubser M, Daniels JS, Jones CK, Conn PJ, Lindsley CW (2014) ACS Chem Biol 9: 2334-46 Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression. Nedelcheva V, Gut I, Soucek P, Tichavská B, Týnkova L, Mráz J, Guengerich FP, Ingelman-Sundberg M (1999) Arch Toxicol 73: 33-40 Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance. Yun CH, Wood M, Wood AJ, Guengerich FP (1992) Anesthesiology 77: 467-74 Establishment of CYP2D6 reference samples by multiple validated genotyping platforms. Fang H, Liu X, Ramírez J, Choudhury N, Kubo M, Im HK, Konkashbaev A, Cox NJ, Ratain MJ, Nakamura Y, O'Donnell PH (2014) Pharmacogenomics J 14: 564-72 Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG (2014) J Biol Chem 289: 29614-30 Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP (2012) J Biol Chem 287: 29554-67 Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines. Guengerich FP, Böcker RH (1988) J Biol Chem 263: 8168-75 Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. Plastaras JP, Guengerich FP, Nebert DW, Marnett LJ (2000) J Biol Chem 275: 11784-90 Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP (2008) J Biol Chem 283: 17147-57 Evidence for specific base catalysis in N-dealkylation reactions catalyzed by cytochrome P450 and chloroperoxidase. Differences in rates of deprotonation of aminium radicals as an explanation for high kinetic hydrogen isotope effects observed with peroxidases. Okazaki O, Guengerich FP (1993) J Biol Chem 268: 1546-52 Oxidation of halogenated compounds by cytochrome P-450, peroxidases, and model metalloporphyrins. Guengerich FP (1989) J Biol Chem 264: 17098-205 Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation. Bondon A, Macdonald TL, Harris TM, Guengerich FP (1989) J Biol Chem 264: 1988-97 Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase. May JM, Cobb CE, Mendiratta S, Hill KE, Burk RF (1998) J Biol Chem 273: 23039-45
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.