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Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR (2011) J Med Chem 54: 7639-47 Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW (2014) J Med Chem 57: 10192-7 Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. 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Fang H, Liu X, Ramírez J, Choudhury N, Kubo M, Im HK, Konkashbaev A, Cox NJ, Ratain MJ, Nakamura Y, O'Donnell PH (2014) Pharmacogenomics J 14: 564-72 Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG (2014) J Biol Chem 289: 29614-30 Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP (2012) J Biol Chem 287: 29554-67 Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines. Guengerich FP, Böcker RH (1988) J Biol Chem 263: 8168-75 Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. Plastaras JP, Guengerich FP, Nebert DW, Marnett LJ (2000) J Biol Chem 275: 11784-90 Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP (2008) J Biol Chem 283: 17147-57 Evidence for specific base catalysis in N-dealkylation reactions catalyzed by cytochrome P450 and chloroperoxidase. Differences in rates of deprotonation of aminium radicals as an explanation for high kinetic hydrogen isotope effects observed with peroxidases. Okazaki O, Guengerich FP (1993) J Biol Chem 268: 1546-52 Oxidation of halogenated compounds by cytochrome P-450, peroxidases, and model metalloporphyrins. Guengerich FP (1989) J Biol Chem 264: 17098-205 Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation. Bondon A, Macdonald TL, Harris TM, Guengerich FP (1989) J Biol Chem 264: 1988-97
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