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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Publications
- Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide.
Myers PR, Minor RL, Guerra R, Bates JN, Harrison DG
(1990) Nature 345: 161-3 - Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
Vasan RS, Glazer NL, Felix JF, Lieb W, Wild PS, Felix SB, Watzinger N, Larson MG, Smith NL, Dehghan A, Grosshennig A, Schillert A, Teumer A, Schmidt R, Kathiresan S, Lumley T, Aulchenko YS, König IR, Zeller T, Homuth G, Struchalin M, Aragam J, Bis JC, Rivadeneira F, Erdmann J, Schnabel RB, Dörr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Levy D, Haritunians T, Deckers JW, Stritzke J, Lackner KJ, Völker U, Ingelsson E, Kullo I, Haerting J, O'Donnell CJ, Heckbert SR, Stricker BH, Ziegler A, Reffelmann T, Redfield MM, Werdan K, Mitchell GF, Rice K, Arnett DK, Hofman A, Gottdiener JS, Uitterlinden AG, Meitinger T, Blettner M, Friedrich N, Wang TJ, Psaty BM, van Duijn CM, Wichmann HE, Munzel TF, Kroemer HK, Benjamin EJ, Rotter JI, Witteman JC, Schunkert H, Schmidt H, Völzke H, Blankenberg S
(2009) JAMA 302: 168-78 - Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF
(2001) Nat Med 7: 699-705 - Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein.
Wiley DM, Kim JD, Hao J, Hong CC, Bautch VL, Jin SW
(2011) Nat Cell Biol 13: 686-92 - Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages.
Mueller PA, Zhu L, Tavori H, Huynh K, Giunzioni I, Stafford JM, Linton MF, Fazio S
(2018) Circulation 138: 1850-1863 - Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.
Su YR, Dove DE, Major AS, Hasty AH, Boone B, Linton MF, Fazio S
(2005) Circulation 111: 2373-81 - Mechanisms of interaction between the sulfhydryl precursor L-methionine and glyceryl trinitrate.
Münzel T, Mülsch A, Holtz J, Just H, Harrison DG, Bassenge E
(1992) Circulation 86: 995-1003 - Higher Aortic Stiffness Is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults.
Jefferson AL, Cambronero FE, Liu D, Moore EE, Neal JE, Terry JG, Nair S, Pechman KR, Rane S, Davis LT, Gifford KA, Hohman TJ, Bell SP, Wang TJ, Beckman JA, Carr JJ
(2018) Circulation 138: 1951-1962 - Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice.
Yoshida H, Hasty AH, Major AS, Ishiguro H, Su YR, Gleaves LA, Babaev VR, Linton MF, Fazio S
(2001) Circulation 104: 2820-5 - Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.
Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS
(2004) Circulation 110: 1492-8 - Release of nitrogen oxides from cultured bovine aortic endothelial cells is not impaired by calcium channel antagonists.
Mügge A, Peterson T, Harrison DG
(1991) Circulation 83: 1404-9 - Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox.
Maytin M, Siwik DA, Ito M, Xiao L, Sawyer DB, Liao R, Colucci WS
(2004) Circulation 109: 1168-71 - Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation.
Miriyala S, Gongora Nieto MC, Mingone C, Smith D, Dikalov S, Harrison DG, Jo H
(2006) Circulation 113: 2818-25 - Association of colony-forming units with coronary artery and abdominal aortic calcification.
Cheng S, Cohen KS, Shaw SY, Larson MG, Hwang SJ, McCabe EL, Martin RP, Klein RJ, Hashmi B, Hoffmann U, Fox CS, Vasan RS, O'Donnell CJ, Wang TJ
(2010) Circulation 122: 1176-82 - Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice.
Zhang W, Yancey PG, Su YR, Babaev VR, Zhang Y, Fazio S, Linton MF
(2003) Circulation 108: 2258-63 - Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Risk Score in Young Adults Predicts Coronary Artery and Abdominal Aorta Calcium in Middle Age: The CARDIA Study.
Gidding SS, Rana JS, Prendergast C, McGill H, Carr JJ, Liu K, Colangelo LA, Loria CM, Lima J, Terry JG, Reis JP, McMahan CA
(2016) Circulation 133: 139-46 - Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.
Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem RM, Alexander RW, Murphy TJ
(1992) J Clin Invest 90: 2092-6 - Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.
Münzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison DG
(1995) J Clin Invest 95: 187-94 - Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo.
Babaev VR, Fazio S, Gleaves LA, Carter KJ, Semenkovich CF, Linton MF
(1999) J Clin Invest 103: 1697-705 - Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.
Cyrus T, Witztum JL, Rader DJ, Tangirala R, Fazio S, Linton MF, Funk CD
(1999) J Clin Invest 103: 1597-604 - Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Accad M, Smith SJ, Newland DL, Sanan DA, King LE, Linton MF, Fazio S, Farese RV
(2000) J Clin Invest 105: 711-9 - Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.
Purcell-Huynh DA, Farese RV, Johnson DF, Flynn LM, Pierotti V, Newland DL, Linton MF, Sanan DA, Young SG
(1995) J Clin Invest 95: 2246-57 - Hypercholesterolemia increases endothelial superoxide anion production.
Ohara Y, Peterson TE, Harrison DG
(1993) J Clin Invest 91: 2546-51 - Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo.
McDonald OG, Wamhoff BR, Hoofnagle MH, Owens GK
(2006) J Clin Invest 116: 36-48 - Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.
Minor RL, Myers PR, Guerra R, Bates JN, Harrison DG
(1990) J Clin Invest 86: 2109-16 - Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV
(2001) J Clin Invest 107: 163-71 - Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation.
Biaggioni I, Olafsson B, Robertson RM, Hollister AS, Robertson D
(1987) Circ Res 61: 779-86 - Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E.
Yang H, Roberts LJ, Shi MJ, Zhou LC, Ballard BR, Richardson A, Guo ZM
(2004) Circ Res 95: 1075-81 - Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium.
Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang P, King GL
(2013) Circ Res 113: 418-27 - Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR
(2009) Circ Res 104: 455-65 - A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis.
Wamhoff BR, Hoofnagle MH, Burns A, Sinha S, McDonald OG, Owens GK
(2004) Circ Res 95: 981-8 - L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism.
Wamhoff BR, Bowles DK, McDonald OG, Sinha S, Somlyo AP, Somlyo AV, Owens GK
(2004) Circ Res 95: 406-14 - Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice.
Parastatidis I, Thomson L, Fries DM, Moore RE, Tohyama J, Fu X, Hazen SL, Heijnen HF, Dennehy MK, Liebler DC, Rader DJ, Ischiropoulos H
(2007) Circ Res 101: 368-76 - Systemic delivery of microRNA-181b inhibits nuclear factor-κB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice.
Sun X, He S, Wara AKM, Icli B, Shvartz E, Tesmenitsky Y, Belkin N, Li D, Blackwell TS, Sukhova GK, Croce K, Feinberg MW
(2014) Circ Res 114: 32-40 - Alterations of vascular reactivity in atherosclerosis.
Harrison DG, Freiman PC, Armstrong ML, Marcus ML, Heistad DD
(1987) Circ Res 61: II74-80 - Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction.
Doughan AK, Harrison DG, Dikalov SI
(2008) Circ Res 102: 488-96 - Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages.
Fazio S, Babaev VR, Murray AB, Hasty AH, Carter KJ, Gleaves LA, Atkinson JB, Linton MF
(1997) Proc Natl Acad Sci U S A 94: 4647-52 - Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.
Münzel T, Giaid A, Kurz S, Stewart DJ, Harrison DG
(1995) Proc Natl Acad Sci U S A 92: 5244-8 - Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib.
Latifi Y, Moccetti F, Wu M, Xie A, Packwood W, Qi Y, Ozawa K, Shentu W, Brown E, Shirai T, McCarty OJ, Ruggeri Z, Moslehi J, Chen J, Druker BJ, López JA, Lindner JR
(2019) Blood 133: 1597-1606 - Thrombin induces endocytosis of endoglin and type-II TGF-beta receptor and down-regulation of TGF-beta signaling in endothelial cells.
Tang H, Low B, Rutherford SA, Hao Q
(2005) Blood 105: 1977-85
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