Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease. Ye J, Davé UP, Grishin NV, Goldstein JL, Brown MS (2000) Proc Natl Acad Sci U S A 97: 5123-8 Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. Meyer zu Schwabedissen HE, Tirona RG, Yip CS, Ho RH, Kim RB (2008) Cancer Res 68: 9338-47 Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. Findeisen M, Würker C, Rathmann D, Meier R, Meiler J, Olsson R, Beck-Sickinger AG (2012) J Med Chem 55: 6124-36 Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor. Solorzano CC, Ksontini R, Pruitt JH, Hess PJ, Edwards PD, Kaibara A, Abouhamze A, Auffenberg T, Galardy RE, Vauthey JN, Copeland EM, Edwards CK, Lauwers GY, Clare-Salzler M, MacKay SL, Moldawer LL, Lazarus DD (1997) J Immunol 158: 414-9 γ-Aminobutyric acid (GABA) concentration inversely correlates with basal perfusion in human occipital lobe. Donahue MJ, Rane S, Hussey E, Mason E, Pradhan S, Waddell KW, Ally BA (2014) J Cereb Blood Flow Metab 34: 532-41 Human homolog of Drosophila Hairy and enhancer of split 1, Hes1, negatively regulates δ-catenin (CTNND2) expression in cooperation with E2F1 in prostate cancer. Lu JP, Zhang J, Kim K, Case TC, Matusik RJ, Chen YH, Wolfe M, Nopparat J, Lu Q (2010) Mol Cancer 9: 304 Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits. Vanoye CG, Welch RC, Daniels MA, Manderfield LJ, Tapper AR, Sanders CR, George AL (2009) J Gen Physiol 134: 207-17 Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. Ebert DH, Deussing J, Peters C, Dermody TS (2002) J Biol Chem 277: 24609-17 Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. Robinson MB, Blakely RD, Couto R, Coyle JT (1987) J Biol Chem 262: 14498-506 Processing of procarboxypeptidase A and other zymogens in murine mast cells. Dikov MM, Springman EB, Yeola S, Serafin WE (1994) J Biol Chem 269: 25897-904 Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, Hamm HE (2005) J Biol Chem 280: 25048-59 Synthesis and in vitro efficacy of MMP9-activated NanoDendrons. Samuelson LE, Scherer RL, Matrisian LM, McIntyre JO, Bornhop DJ (2013) Mol Pharm 10: 3164-74 Synaptosomal transport of radiolabel from N-acetyl-aspartyl-[3H]glutamate suggests a mechanism of inactivation of an excitatory neuropeptide. Blakely RD, Ory-Lavollée L, Thompson RC, Coyle JT (1986) J Neurochem 47: 1013-9 Neurochemical and immunocytochemical studies on the distribution of N-acetyl-aspartylglutamate and N-acetyl-aspartate in rat spinal cord and some peripheral nervous tissues. Ory-Lavollée L, Blakely RD, Coyle JT (1987) J Neurochem 48: 895-9 Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate: subcellular and regional distribution, ontogeny, and the effect of lesions on N-acetylated-alpha-linked acidic dipeptidase activity. Blakely RD, Robinson MB, Thompson RC, Coyle JT (1988) J Neurochem 50: 1200-9 DehydroalanylGly, a new post translational modification resulting from the breakdown of glutathione. Friedrich MG, Wang Z, Schey KL, Truscott RJW (2018) Biochim Biophys Acta Gen Subj 1862: 907-913 Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury. Pfeiffer S, Zorn GL, Zhang JP, Giorgio TD, Robson SC, Azimzadeh AM, Pierson RN (2003) Transplantation 75: 953-9 Characterization of isothiocyanates, thioureas, and other lysine adduction products in carbon disulfide-treated peptides and protein. DeCaprio AP, Spink DC, Chen X, Fowke JH, Zhu M, Bank S (1992) Chem Res Toxicol 5: 496-504 SC-49992--a potent and specific inhibitor of platelet aggregation. Nicholson NS, Panzer-Knodle SG, King LW, Taite BB, Keller BT, Tjoeng FS, Engleman VW, Giorgio TD, Feigen LP (1994) Thromb Res 74: 523-35 A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin. Zhou YP, Sreenan S, Pan CY, Currie KP, Bindokas VP, Horikawa Y, Lee JP, Ostrega D, Ahmed N, Baldwin AC, Cox NJ, Fox AP, Miller RJ, Bell GI, Polonsky KS (2003) Metabolism 52: 528-34 Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay. Guarda AS, Robinson MB, Ory-Lavollée L, Forloni GL, Blakely RD, Coyle JT (1988) Brain Res 427: 223-31 New RGD analogue inhibits human platelet adhesion and aggregation and eliminates platelet deposition on canine vascular grafts. Rubin BG, McGraw DJ, Sicard GA, Santoro SA (1992) J Vasc Surg 15: 683-91; discussion 691-2 Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate. Blakely RD, Ory-Lavollée L, Grzanna R, Koller KJ, Coyle JT (1987) Brain Res 402: 373-8 A computer-based protocol for semiautomated assignments and 3D structure determination of proteins. Meadows RP, Olejniczak ET, Fesik SW (1994) J Biomol NMR 4: 79-96 Peptide tyrosine tyrosine levels are increased in patients with urea cycle disorders. Mitchell S, Welch-Burke T, Dumitrescu L, Lomenick JP, Murdock DG, Crawford DC, Summar M (2012) Mol Genet Metab 106: 39-42 A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality. Solorzano CC, Ksontini R, Pruitt JH, Auffenberg T, Tannahill C, Galardy RE, Schultz GP, MacKay SL, Copeland EM, Moldawer LL (1997) Shock 7: 427-31 Quisqualate selectively inhibits a brain peptidase which cleaves N-acetyl-L-aspartyl-L-glutamate in vitro. Robinson MB, Blakely RD, Coyle JT (1986) Eur J Pharmacol 130: 345-7 A re-examination of the interaction of N-acetyl-L-aspartyl-L-glutamate with a subpopulation of rat brain membrane L-[3H]glutamate binding sites. Blakely RD, Robinson MB, Guarda AS, Coyle JT (1988) Eur J Pharmacol 151: 419-26 Co-localization of N-acetyl-aspartyl-glutamate in central cholinergic, noradrenergic, and serotonergic neurons. Forloni G, Grzanna R, Blakely RD, Coyle JT (1987) Synapse 1: 455-60 Specific alterations in the levels of N-acetyl-aspartyl-glutamate in the nervous system of the dystrophic mouse. Blakely RD, Ory-Lavollée L, Coyle JT (1987) Neurosci Lett 79: 223-8 Acidic peptides in brain: do they act at putative glutamatergic synapses? Coyle JT, Blakely R, Zaczek R, Koller KJ, Abreu M, Ory-Lavollée L, Fisher R, ffrench-Mullen JM, Carpenter DO (1986) Adv Exp Med Biol 203: 375-84 The neurobiology of N-acetylaspartylglutamate. Blakely RD, Coyle JT (1988) Int Rev Neurobiol 30: 39-100
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