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•  James Crowe

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Publications

• Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.
  Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, Kudchadkar R, Burris HA, Falchook G, Algazi A, Lewis K, Long GV, Puzanov I, Lebowitz P, Singh A, Little S, Sun P, Allred A, Ouellet D, Kim KB, Patel K, Weber J
  (2012) N Engl J Med 367: 1694-703
• Epiglottitis.
  Chapurin N, Gelbard A
  (2019) N Engl J Med 381: e15
• The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group.
  Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson WJ, Wright PE, Christman BW, Dupont WD, Higgins SB, Swindell BB
  (1997) N Engl J Med 336: 912-8
• Clinical problem-solving. High time for action.
  Kallianpur AR, Poehling KA, Dittus RS
  (2001) N Engl J Med 344: 48-51
• Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection.
  Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, Doranz BJ, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Saphire EO, Ward AB, Bukreyev A, Crowe JE
  (2016) Cell 164: 392-405
• A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
  Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE, Aman MJ, Dye JM, Lai JR, Chandran K
  (2016) Science 354: 350-354
• Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.
  Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Sevy AM, Bombardi RG, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Saphire EO, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, Crowe JE
  (2018) Immunity 49: 363-374.e10
• Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
  Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE
  (2020) Immunity 52: 388-403.e12
• EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses.
  Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB
  (2007) Nat Neurosci 10: 1131-3
• Repetitive weekly cycles of interleukin-2. II. Clinical and immunologic effects of dose, schedule, and addition of indomethacin.
  Sosman JA, Kohler PC, Hank JA, Moore KH, Bechhofer R, Storer B, Sondel PM
  (1988) J Natl Cancer Inst 80: 1451-61
• Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.
  Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomandiak S, Khomadiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, Brien JD, Austin SK, Diamond MS, Dermody TS, Crowe JE
  (2015) Cell Host Microbe 18: 86-95
• Universal flu vaccines: primum non nocere.
  Crowe JE
  (2013) Sci Transl Med 5: 200fs34
• Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis.
  Miner JJ, Cook LE, Hong JP, Smith AM, Richner JM, Shimak RM, Young AR, Monte K, Poddar S, Crowe JE, Lenschow DJ, Diamond MS
  (2017) Sci Transl Med 9:
• Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.
  Long F, Fong RH, Austin SK, Chen Z, Klose T, Fokine A, Liu Y, Porta J, Sapparapu G, Akahata W, Doranz BJ, Crowe JE, Diamond MS, Rossmann MG
  (2015) Proc Natl Acad Sci U S A 112: 13898-903
• Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia.
  Matsumoto RR, Seminerio MJ, Turner RC, Robson MJ, Nguyen L, Miller DB, O'Callaghan JP
  (2014) Pharmacol Ther 144: 28-40
• Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans.
  Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP
  (2015) Hum Mol Genet 24: 1801-12
• Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism.
  Baucum AJ, Rau KS, Riddle EL, Hanson GR, Fleckenstein AE
  (2004) J Neurosci 24: 3436-43
• Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group.
  Arons MM, Wheeler AP, Bernard GR, Christman BW, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson W, Wright P, Dupont WD, Swindell BB
  (1999) Crit Care Med 27: 699-707
• Genetic predisposition for adverse events after vaccination.
  Crowe JE
  (2007) J Infect Dis 196: 176-7
• Rhinovirus-associated hospitalizations in young children.
  Miller EK, Lu X, Erdman DD, Poehling KA, Zhu Y, Griffin MR, Hartert TV, Anderson LJ, Weinberg GA, Hall CB, Iwane MK, Edwards KM, New Vaccine Surveillance Network
  (2007) J Infect Dis 195: 773-81
• Sirolimus-associated diffuse alveolar hemorrhage.
  Vlahakis NE, Rickman OB, Morgenthaler T
  (2004) Mayo Clin Proc 79: 541-5
• Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.
  Bornholdt ZA, Ndungo E, Fusco ML, Bale S, Flyak AI, Crowe JE, Chandran K, Saphire EO
  (2016) mBio 7: e02154-15
• The Molecular Basis for the Lack of Inflammatory Responses in Mouse Embryonic Stem Cells and Their Differentiated Cells.
  D'Angelo W, Gurung C, Acharya D, Chen B, Ortolano N, Gama V, Bai F, Guo YL
  (2017) J Immunol 198: 2147-2155
• Chemoprophylaxis of bacterial endocarditis--a survey of current practice in Zimbabwe.
  Murenha E, Stein CM
  (1990) J Antimicrob Chemother 25: 291-6
• Fever, thrombocytopenia, anasarca, and acute renal failure in a 50-year-old woman.
  Goral S, Horn R, Brouillette J, Fogo A
  (1998) Am J Kidney Dis 31: 890-5
• A 17-year-old with rash, fever, myalgias, and nephritis.
  Byrd VM, Graham BS, Stock KJ, Fogo A
  (1998) Am J Kidney Dis 32: 848-52
• Quiz page. Mesangial lupus nephritis, WHO IIb, and severe acute tubular necrosis, secondary to gentamycin toxicity.
  Fogo AB
  (2002) Am J Kidney Dis 40: xlix
• Clinical parameters associated with low bacteremia risk in 1100 pediatric oncology patients with fever and neutropenia.
  Baorto EP, Aquino VM, Mullen CA, Buchanan GR, DeBaun MR
  (2001) Cancer 92: 909-13
• Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection.
  Williamson LE, Flyak AI, Kose N, Bombardi R, Branchizio A, Reddy S, Davidson E, Doranz BJ, Fusco ML, Saphire EO, Halfmann PJ, Kawaoka Y, Piper AE, Glass PJ, Crowe JE
  (2019) J Virol 93:
• A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization.
  Silva LA, Khomandiak S, Ashbrook AW, Weller R, Heise MT, Morrison TE, Dermody TS
  (2014) J Virol 88: 2385-97
• Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine.
  Kimble JB, Malherbe DC, Meyer M, Gunn BM, Karim MM, Ilinykh PA, Iampietro M, Mohamed KS, Negi S, Gilchuk P, Huang K, Wolf YI, Braun W, Crowe JE, Alter G, Bukreyev A
  (2019) J Virol 93:
• VU0810464, a non-urea G protein-gated inwardly rectifying K (K 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K 3 channels and reduces stress-induced hyperthermia in mice.
  Vo BN, Abney KK, Anderson A, Marron Fernandez de Velasco E, Benneyworth MA, Daniels JS, Morrison RD, Hopkins CR, Weaver CD, Wickman K
  (2019) Br J Pharmacol 176: 2238-2249
• Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch.
  Voehler MW, Eoff RL, McDonald WH, Guengerich FP, Stone MP
  (2009) J Biol Chem 284: 18434-44
• SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation.
  Robson MJ, Turner RC, Naser ZJ, McCurdy CR, O'Callaghan JP, Huber JD, Matsumoto RR
  (2014) Exp Neurol 254: 180-9
• Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo.
  Kaushal N, Seminerio MJ, Robson MJ, McCurdy CR, Matsumoto RR
  (2013) Eur Neuropsychopharmacol 23: 960-71
• Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012.
  Khuri-Bulos N, Payne DC, Lu X, Erdman D, Wang L, Faouri S, Shehabi A, Johnson M, Becker MM, Denison MR, Williams JV, Halasa NB
  (2014) Clin Microbiol Infect 20: 678-82
• Major outbreak of toxic shock-like syndrome caused by Streptococcus mitis.
  Lu HZ, Weng XH, Zhu B, Li H, Yin YK, Zhang YX, Haas DW, Tang YW
  (2003) J Clin Microbiol 41: 3051-5
• Preengraftment syndrome after unrelated cord blood transplant is a strong predictor of acute and chronic graft-versus-host disease.
  Frangoul H, Wang L, Harrell FE, Ho R, Domm J
  (2009) Biol Blood Marrow Transplant 15: 1485-8
• Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome.
  Calhoun JD, Hawkins NA, Zachwieja NJ, Kearney JA
  (2017) Epilepsia 58: e111-e115
• Abacavir-reactive memory T cells are present in drug naïve individuals.
  Lucas A, Lucas M, Strhyn A, Keane NM, McKinnon E, Pavlos R, Moran EM, Meyer-Pannwitt V, Gaudieri S, D'Orsogna L, Kalams S, Ostrov DA, Buus S, Peters B, Mallal S, Phillips E
  (2015) PLoS One 10: e0117160