The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Noel JP, Hamm HE, Sigler PB (1993) Nature 366: 654-63 Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB (1996) Nature 379: 369-74 GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB (1994) Nature 372: 276-9 Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Lambright DG, Noel JP, Hamm HE, Sigler PB (1994) Nature 369: 621-8 Molecular basis for interactions of G protein betagamma subunits with effectors. Ford CE, Skiba NP, Bae H, Daaka Y, Reuveny E, Shekter LR, Rosal R, Weng G, Yang CS, Iyengar R, Miller RJ, Jan LY, Lefkowitz RJ, Hamm HE (1998) Science 280: 1271-4 Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit. Hamm HE, Deretic D, Arendt A, Hargrave PA, Koenig B, Hofmann KP (1988) Science 241: 832-5 Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Nair KS, Hanson SM, Mendez A, Gurevich EV, Kennedy MJ, Shestopalov VI, Vishnivetskiy SA, Chen J, Hurley JB, Gurevich VV, Slepak VZ (2005) Neuron 46: 555-67 How activated receptors couple to G proteins. Hamm HE (2001) Proc Natl Acad Sci U S A 98: 4819-21 Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1. Westfall JE, Hoyt C, Liu Q, Hsiao YC, Pierce EA, Page-McCaw PS, Ferland RJ (2010) J Neurosci 30: 8759-68 Interaction of rhodopsin with the G-protein, transducin. Hargrave PA, Hamm HE, Hofmann KP (1993) Bioessays 15: 43-50 Topographic analysis of antigenic determinants recognized by monoclonal antibodies to the photoreceptor guanyl nucleotide-binding protein, transducin. Deretic D, Hamm HE (1987) J Biol Chem 262: 10839-47 Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotide-binding protein, transducin. Hamm HE, Deretic D, Hofmann KP, Schleicher A, Kohl B (1987) J Biol Chem 262: 10831-8 Regulation of transducin GTPase activity in bovine rod outer segments. Arshavsky VY, Dumke CL, Zhu Y, Artemyev NO, Skiba NP, Hamm HE, Bownds MD (1994) J Biol Chem 269: 19882-7 Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras. Skiba NP, Bae H, Hamm HE (1996) J Biol Chem 271: 413-24 Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding. Thulin CD, Savage JR, McLaughlin JN, Truscott SM, Old WM, Ahn NG, Resing KA, Hamm HE, Bitensky MW, Willardson BM (2001) J Biol Chem 276: 23805-15 A monoclonal antibody against the rod outer segment guanyl nucleotide-binding protein, transducin, blocks the stimulatory and inhibitory G proteins of adenylate cyclase. Hamm HE, Deretic D, Mazzoni MR, Moore CA, Takahashi JS, Rasenick MM (1989) J Biol Chem 264: 11475-82 The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin. Skiba NP, Artemyev NO, Hamm HE (1995) J Biol Chem 270: 13210-5 A site on transducin alpha-subunit of interaction with the polycationic region of cGMP phosphodiesterase inhibitory subunit. Artemyev NO, Mills JS, Thornburg KR, Knapp DR, Schey KL, Hamm HE (1993) J Biol Chem 268: 23611-5 Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin. Krupnick JG, Gurevich VV, Benovic JL (1997) J Biol Chem 272: 18125-31 Structural requirements for the stabilization of metarhodopsin II by the C terminus of the alpha subunit of transducin. Aris L, Gilchrist A, Rens-Domiano S, Meyer C, Schatz PJ, Dratz EA, Hamm HE (2001) J Biol Chem 276: 2333-9 Functional roles of the two domains of phosducin and phosducin-like protein. Savage JR, McLaughlin JN, Skiba NP, Hamm HE, Willardson BM (2000) J Biol Chem 275: 30399-407 Closely related G-protein-coupled receptors use multiple and distinct domains on G-protein alpha-subunits for selective coupling. Slessareva JE, Ma H, Depree KM, Flood LA, Bae H, Cabrera-Vera TM, Hamm HE, Graber SG (2003) J Biol Chem 278: 50530-6 Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. Dimitrova YN, Li J, Lee YT, Rios-Esteves J, Friedman DB, Choi HJ, Weis WI, Wang CY, Chazin WJ (2010) J Biol Chem 285: 13507-16 Interaction of transducin with light-activated rhodopsin protects It from proteolytic digestion by trypsin. Mazzoni MR, Hamm HE (1996) J Biol Chem 271: 30034-40 Cyclic AMP-dependent phosphoprotein components I and II interact with beta gamma subunits of transducin in frog rod outer segments. Suh KH, Hamm HE (1996) Biochemistry 35: 290-8 Coupling efficiency of rhodopsin and transducin in bicelles. Kaya AI, Thaker TM, Preininger AM, Iverson TM, Hamm HE (2011) Biochemistry 50: 3193-203 Competition between lithium and magnesium ions for the G-protein transducin in the guanosine 5'-diphosphate bound conformation. Srinivasan C, Toon J, Amari L, Abukhdeir AM, Hamm H, Geraldes CF, Ho YK, Mota de Freitas D (2004) J Inorg Biochem 98: 691-701 Molecular interactions between the photoreceptor G protein and rhodopsin. Hamm HE (1991) Cell Mol Neurobiol 11: 563-78 Structural characterization of intact G protein gamma subunits by mass spectrometry. Schey KL, Busman M, Cook LA, Hamm HE, Hildebrandt JD (2002) Methods Enzymol 344: 586-97 Fluorescent probes as indicators of conformation changes in transducin on activation. Yang CS, Skiba NP, Mazzoni MR, Thomas TO, Hamm HE (2000) Methods Enzymol 315: 490-502 G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t. Skiba NP, Thomas TO, Hamm HE (2000) Methods Enzymol 315: 502-24
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