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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Genetic Vectors are shown below. Double-click or tap a node for more information.
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Publications
- Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis.
Bushdid PB, Brantley DM, Yull FE, Blaeuer GL, Hoffman LH, Niswander L, Kerr LD
(1998) Nature 392: 615-8 - Functional genomics in mice by tagged sequence mutagenesis.
Hicks GG, Shi EG, Li XM, Li CH, Pawlak M, Ruley HE
(1997) Nat Genet 16: 338-44 - Growth retardation and tumour inhibition by BRCA1.
Holt JT, Thompson ME, Szabo C, Robinson-Benion C, Arteaga CL, King MC, Jensen RA
(1996) Nat Genet 12: 298-302 - CRISPR-Cas9 knockin mice for genome editing and cancer modeling.
Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F
(2014) Cell 159: 440-55 - Gene therapy insertional mutagenesis insights.
Davé UP, Jenkins NA, Copeland NG
(2004) Science 303: 333 - Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.
Sorrentino BP, Brandt SJ, Bodine D, Gottesman M, Pastan I, Cline A, Nienhuis AW
(1992) Science 257: 99-103 - Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.
Brown CB, Boyer AS, Runyan RB, Barnett JV
(1999) Science 283: 2080-2 - Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery.
Wei J, Blum S, Unger M, Jarmy G, Lamparter M, Geishauser A, Vlastos GA, Chan G, Fischer KD, Rattat D, Debatin KM, Hatzopoulos AK, Beltinger C
(2004) Cancer Cell 5: 477-88 - Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer.
Roth JA, Nguyen D, Lawrence DD, Kemp BL, Carrasco CH, Ferson DZ, Hong WK, Komaki R, Lee JJ, Nesbitt JC, Pisters KM, Putnam JB, Schea R, Shin DM, Walsh GL, Dolormente MM, Han CI, Martin FD, Yen N, Xu K, Stephens LC, McDonnell TJ, Mukhopadhyay T, Cai D
(1996) Nat Med 2: 985-91 - Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer.
Nemunaitis J, Swisher SG, Timmons T, Connors D, Mack M, Doerksen L, Weill D, Wait J, Lawrence DD, Kemp BL, Fossella F, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Nguyen DM, Nesbitt JC, Perez-Soler R, Pisters KM, Putnam JB, Richli WR, Shin DM, Walsh GL, Merritt J, Roth J
(2000) J Clin Oncol 18: 609-22 - Retroviral gene therapy in ApoE-deficient mice: ApoE expression in the artery wall reduces early foam cell lesion formation.
Hasty AH, Linton MF, Brandt SJ, Babaev VR, Gleaves LA, Fazio S
(1999) Circulation 99: 2571-6 - Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment.
Osipovich AB, Singh A, Ruley HE
(2005) Genome Res 15: 428-35 - Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer.
Swisher SG, Roth JA, Nemunaitis J, Lawrence DD, Kemp BL, Carrasco CH, Connors DG, El-Naggar AK, Fossella F, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Mack M, Merritt JA, Nguyen DM, Nesbitt JC, Perez-Soler R, Pisters KM, Putnam JB, Richli WR, Savin M, Schrump DS, Shin DM, Shulkin A, Walsh GL, Wait J, Weill D, Waugh MK
(1999) J Natl Cancer Inst 91: 763-71 - MiRNA inhibition in tissue engineering and regenerative medicine.
Beavers KR, Nelson CE, Duvall CL
(2015) Adv Drug Deliv Rev 88: 123-37 - Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family.
Wei J, O'Brien D, Vilgelm A, Piazuelo MB, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika A
(2008) Gastroenterology 134: 1412-23 - Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice.
Allocca M, Doria M, Petrillo M, Colella P, Garcia-Hoyos M, Gibbs D, Kim SR, Maguire A, Rex TS, Di Vicino U, Cutillo L, Sparrow JR, Williams DS, Bennett J, Auricchio A
(2008) J Clin Invest 118: 1955-64 - Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.
Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW
(1990) J Clin Invest 86: 592-9 - Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.
Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V, Arteaga CL
(2002) J Clin Invest 109: 1551-9 - Selective disruption of genes expressed in totipotent embryonal stem cells.
von Melchner H, DeGregori JV, Rayburn H, Reddy S, Friedel C, Ruley HE
(1992) Genes Dev 6: 919-27 - Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing.
Chiou SH, Winters IP, Wang J, Naranjo S, Dudgeon C, Tamburini FB, Brady JJ, Yang D, Grüner BM, Chuang CH, Caswell DR, Zeng H, Chu P, Kim GE, Carpizo DR, Kim SK, Winslow MM
(2015) Genes Dev 29: 1576-85 - cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.
Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, Kass DA
(2005) Circ Res 96: 100-9 - Assessing the functional characteristics of synonymous and nonsynonymous mutation candidates by use of large DNA constructs.
Eeds AM, Mortlock D, Wade-Martins R, Summar ML
(2007) Am J Hum Genet 80: 740-50 - c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Palmada M, Kanwal S, Rutkoski NJ, Gustafson-Brown C, Johnson RS, Wisdom R, Carter BD, Gufstafson-Brown C
(2002) J Cell Biol 158: 453-61 - Comparison of the effects of recombinant adenovirus-mediated expression of wild-type p53 and p27Kip1 on cell cycle and apoptosis in SUDHL-1 cells derived from anaplastic large cell lymphoma.
Turturro F, Frist AY, Arnold MD, Pal A, Cook GA, Seth P
(2001) Leukemia 15: 1225-31 - Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo.
O'Neil RT, Saha S, Veach RA, Welch RC, Woodard LE, Rooney CM, Wilson MH
(2018) Nat Commun 9: 1325 - Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.
Reynolds AB, Vila J, Lansing TJ, Potts WM, Weber MJ, Parsons JT
(1987) EMBO J 6: 2359-64 - Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance.
Pao W, Klimstra DS, Fisher GH, Varmus HE
(2003) Proc Natl Acad Sci U S A 100: 8764-9 - Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.
Thier R, Taylor JB, Pemble SE, Humphreys WG, Persmark M, Ketterer B, Guengerich FP
(1993) Proc Natl Acad Sci U S A 90: 8576-80 - Another version of the human insulin receptor kinase domain: expression, purification, and characterization.
Villalba M, Wente SR, Russell DS, Ahn JC, Reichelderfer CF, Rosen OM
(1989) Proc Natl Acad Sci U S A 86: 7848-52 - Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels.
Bankston JR, Camp SS, DiMaio F, Lewis AS, Chetkovich DM, Zagotta WN
(2012) Proc Natl Acad Sci U S A 109: 7899-904 - A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1.
Mercier GT, Campbell JA, Chappell JD, Stehle T, Dermody TS, Barry MA
(2004) Proc Natl Acad Sci U S A 101: 6188-93 - piggyBac-ing models and new therapeutic strategies.
Woodard LE, Wilson MH
(2015) Trends Biotechnol 33: 525-33 - Microfilament dynamics during cell movement and chemotaxis monitored using a GFP-actin fusion protein.
Westphal M, Jungbluth A, Heidecker M, Mühlbauer B, Heizer C, Schwartz JM, Marriott G, Gerisch G
(1997) Curr Biol 7: 176-83 - The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes.
Liu Q, Li MZ, Leibham D, Cortez D, Elledge SJ
(1998) Curr Biol 8: 1300-9 - Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells.
Ueda Y, Neel NF, Schutyser E, Raman D, Richmond A
(2006) Cancer Res 66: 5665-75 - Adenovirus-mediated tissue-targeted expression of a caspase-9-based artificial death switch for the treatment of prostate cancer.
Xie X, Zhao X, Liu Y, Zhang J, Matusik RJ, Slawin KM, Spencer DM
(2001) Cancer Res 61: 6795-804 - Tissue-targeted antisense c-fos retroviral vector inhibits established breast cancer xenografts in nude mice.
Arteaga CL, Holt JT
(1996) Cancer Res 56: 1098-1103 - Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models.
Lanuti M, Rudginsky S, Force SD, Lambright ES, Siders WM, Chang MY, Amin KM, Kaiser LR, Scheule RK, Albelda SM
(2000) Cancer Res 60: 2955-63 - Mutagenesis of diploid mammalian genes by gene entrapment.
Lin Q, Donahue SL, Moore-Jarrett T, Cao S, Osipovich AB, Ruley HE
(2006) Nucleic Acids Res 34: e139 - Activation of cryptic 3' splice sites within introns of cellular genes following gene entrapment.
Osipovich AB, White-Grindley EK, Hicks GG, Roshon MJ, Shaffer C, Moore JH, Ruley HE
(2004) Nucleic Acids Res 32: 2912-24
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