Keyword Connections

•  Bruce Damon
•  Christopher Elder

•  David Wasserman
•  Jorge Gamboa

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Publications

• Disruption of IRS-2 causes type 2 diabetes in mice.
  Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
  (1998) Nature 391: 900-4
• Mox2 is a component of the genetic hierarchy controlling limb muscle development.
  Mankoo BS, Collins NS, Ashby P, Grigorieva E, Pevny LH, Candia A, Wright CV, Rigby PW, Pachnis V
  (1999) Nature 400: 69-73
• Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
  Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA
  (2013) Cell 155: 1624-38
• Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.
  Arima Y, Harada M, Kamimura D, Park JH, Kawano F, Yull FE, Kawamoto T, Iwakura Y, Betz UA, Márquez G, Blackwell TS, Ohira Y, Hirano T, Murakami M
  (2012) Cell 148: 447-57
• Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
  Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y
  (2006) Science 312: 1656-9
• Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
  An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB
  (2004) Nat Med 10: 268-74
• Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
  Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
  (2016) Nat Med 22: 800-6
• Blockade of nucleoside transport is required for delivery of intraarterial adenosine into the interstitium: relevance to therapeutic preconditioning in humans.
  Gamboa A, Ertl AC, Costa F, Farley G, Manier ML, Hachey DL, Diedrich A, Biaggioni I
  (2003) Circulation 108: 2631-5
• Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction.
  Jain M, DerSimonian H, Brenner DA, Ngoy S, Teller P, Edge AS, Zawadzka A, Wetzel K, Sawyer DB, Colucci WS, Apstein CS, Liao R
  (2001) Circulation 103: 1920-7
• Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.
  Chen S, Wasserman DH, MacKintosh C, Sakamoto K
  (2011) Cell Metab 13: 68-79
• SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
  Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA
  (2012) Cell Metab 15: 675-90
• Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.
  Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE, Clasey JL, Heymsfield SB, Bach MA, Vance ML, Thorner MO
  (2008) Ann Intern Med 149: 601-11
• MiRNA inhibition in tissue engineering and regenerative medicine.
  Beavers KR, Nelson CE, Duvall CL
  (2015) Adv Drug Deliv Rev 88: 123-37
• Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults.
  Fabbrini E, Tamboli RA, Magkos F, Marks-Shulman PA, Eckhauser AW, Richards WO, Klein S, Abumrad NN
  (2010) Gastroenterology 139: 448-55
• High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.
  Kitada K, Daub S, Zhang Y, Klein JD, Nakano D, Pedchenko T, Lantier L, LaRocque LM, Marton A, Neubert P, Schröder A, Rakova N, Jantsch J, Dikalova AE, Dikalov SI, Harrison DG, Müller DN, Nishiyama A, Rauh M, Harris RC, Luft FC, Wassermann DH, Sands JM, Titze J
  (2017) J Clin Invest 127: 1944-1959
• Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration.
  Majka SM, Jackson KA, Kienstra KA, Majesky MW, Goodell MA, Hirschi KK
  (2003) J Clin Invest 111: 71-9
• Insulin exits skeletal muscle capillaries by fluid-phase transport.
  Williams IM, Valenzuela FA, Kahl SD, Ramkrishna D, Mezo AR, Young JD, Wells KS, Wasserman DH
  (2018) J Clin Invest 128: 699-714
• Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle.
  Hamilton KS, Gibbons FK, Bracy DP, Lacy DB, Cherrington AD, Wasserman DH
  (1996) J Clin Invest 98: 125-35
• Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.
  Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD
  (2009) J Clin Invest 119: 573-81
• Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients.
  Pupim LB, Flakoll PJ, Brouillette JR, Levenhagen DK, Hakim RM, Ikizler TA
  (2002) J Clin Invest 110: 483-92
• Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro.
  Siwik DA, Tzortzis JD, Pimental DR, Chang DL, Pagano PJ, Singh K, Sawyer DB, Colucci WS
  (1999) Circ Res 85: 147-53
• Human skeletal muscle drug transporters determine local exposure and toxicity of statins.
  Knauer MJ, Urquhart BL, Meyer zu Schwabedissen HE, Schwarz UI, Lemke CJ, Leake BF, Kim RB, Tirona RG
  (2010) Circ Res 106: 297-306
• Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice.
  Exil VJ, Roberts RL, Sims H, McLaughlin JE, Malkin RA, Gardner CD, Ni G, Rottman JN, Strauss AW
  (2003) Circ Res 93: 448-55
• The Vasculature in Prediabetes.
  Wasserman DH, Wang TJ, Brown NJ
  (2018) Circ Res 122: 1135-1150
• Normal levels of wild-type mitochondrial DNA maintain cytochrome c oxidase activity for two pathogenic mitochondrial DNA mutations but not for m.3243A-->G.
  Durham SE, Samuels DC, Cree LM, Chinnery PF
  (2007) Am J Hum Genet 81: 189-95
• Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait.
  Torres JM, Gamazon ER, Parra EJ, Below JE, Valladares-Salgado A, Wacher N, Cruz M, Hanis CL, Cox NJ
  (2014) Am J Hum Genet 95: 521-34
• Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome.
  Miner JH, Sanes JR
  (1996) J Cell Biol 135: 1403-13
• Metabolic signatures of exercise in human plasma.
  Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE
  (2010) Sci Transl Med 2: 33ra37
• What is influencing the phenotype of the common homozygous polymerase-γ mutation p.Ala467Thr?
  Neeve VC, Samuels DC, Bindoff LA, van den Bosch B, Van Goethem G, Smeets H, Lombès A, Jardel C, Hirano M, Dimauro S, De Vries M, Smeitink J, Smits BW, de Coo IF, Saft C, Klopstock T, Keiling BC, Czermin B, Abicht A, Lochmüller H, Hudson G, Gorman GG, Turnbull DM, Taylor RW, Holinski-Feder E, Chinnery PF, Horvath R
  (2012) Brain 135: 3614-26
• Implications of glucocorticoid therapy in idiopathic inflammatory myopathies.
  Hanaoka BY, Peterson CA, Horbinski C, Crofford LJ
  (2012) Nat Rev Rheumatol 8: 448-57
• Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.
  Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK
  (2012) Proc Natl Acad Sci U S A 109: 6739-44
• Two heads of myosin are better than one for generating force and motion.
  Tyska MJ, Dupuis DE, Guilford WH, Patlak JB, Waller GS, Trybus KM, Warshaw DM, Lowey S
  (1999) Proc Natl Acad Sci U S A 96: 4402-7
• Expanding roles for AMPK in skeletal muscle plasticity.
  Mounier R, Théret M, Lantier L, Foretz M, Viollet B
  (2015) Trends Endocrinol Metab 26: 275-86
• Mitochondrial DNA copy number threshold in mtDNA depletion myopathy.
  Durham SE, Bonilla E, Samuels DC, DiMauro S, Chinnery PF
  (2005) Neurology 65: 453-5
• Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus.
  Pupim LB, Flakoll PJ, Majchrzak KM, Aftab Guy DL, Stenvinkel P, Ikizler TA
  (2005) Kidney Int 68: 1857-65
• Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients.
  Siew ED, Pupim LB, Majchrzak KM, Shintani A, Flakoll PJ, Ikizler TA
  (2007) Kidney Int 71: 146-52
• Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.
  Kumar A, Lawrence JC, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE
  (2010) Diabetes 59: 1397-406
• Heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion, but not insulin action, in high-fat-fed mice.
  Kang L, Dai C, Lustig ME, Bonner JS, Mayes WH, Mokshagundam S, James FD, Thompson CS, Lin CT, Perry CG, Anderson EJ, Neufer PD, Wasserman DH, Powers AC
  (2014) Diabetes 63: 3699-710