Transfusions for silent cerebral infarcts in sickle cell anemia. DeBaun MR, Casella JF (2014) N Engl J Med 371: 1841-2 Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. DeBaun MR, Gordon M, McKinstry RC, Noetzel MJ, White DA, Sarnaik SA, Meier ER, Howard TH, Majumdar S, Inusa BP, Telfer PT, Kirby-Allen M, McCavit TL, Kamdem A, Airewele G, Woods GM, Berman B, Panepinto JA, Fuh BR, Kwiatkowski JL, King AA, Fixler JM, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Dixon N, Gonzalez CE, Kalinyak KA, Quinn CT, Strouse JJ, Miller JP, Lehmann H, Kraut MA, Ball WS, Hirtz D, Casella JF (2014) N Engl J Med 371: 699-710 The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia. DeBaun MR, Strunk RC (2016) Lancet 387: 2545-53 New option for primary stroke prevention in sickle cell anaemia. DeBaun MR, Kirkham FJ (2016) Lancet 387: 626-7 Perspective: thinking beyond survival. DeBaun MR (2014) Nature 515: S16 The challenge of creating an evidence-based guideline for sickle cell disease. DeBaun MR (2014) JAMA 312: 1004-5 Sickle cell disease, vasculopathy, and therapeutics. Kassim AA, DeBaun MR (2013) Annu Rev Med 64: 451-66 Molecular aspects of sickle cell disease. Waterman MR, Cottam GL (1976) Angew Chem Int Ed Engl 15: 749-57 Elevation of IgE in children with sickle cell disease is associated with doctor diagnosis of asthma and increased morbidity. An P, Barron-Casella EA, Strunk RC, Hamilton RG, Casella JF, DeBaun MR (2011) J Allergy Clin Immunol 127: 1440-6 Noncovalent modification of deoxyhemoglobin S solubility and erythrocyte sickling. Waterman MR, Yamaoka K, Dahm L, Taylor J, Cottam GL (1974) Proc Natl Acad Sci U S A 71: 2222-5 Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Hulbert ML, McKinstry RC, Lacey JL, Moran CJ, Panepinto JA, Thompson AA, Sarnaik SA, Woods GM, Casella JF, Inusa B, Howard J, Kirkham FJ, Anie KA, Mullin JE, Ichord R, Noetzel M, Yan Y, Rodeghier M, Debaun MR (2011) Blood 117: 772-9 Central nervous system complications and management in sickle cell disease. DeBaun MR, Kirkham FJ (2016) Blood 127: 829-38 Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans. Bae HT, Baldwin CT, Sebastiani P, Telen MJ, Ashley-Koch A, Garrett M, Hooper WC, Bean CJ, Debaun MR, Arking DE, Bhatnagar P, Casella JF, Keefer JR, Barron-Casella E, Gordeuk V, Kato GJ, Minniti C, Taylor J, Campbell A, Luchtman-Jones L, Hoppe C, Gladwin MT, Zhang Y, Steinberg MH (2012) Blood 120: 1961-2 Histopathology of experimentally induced asthma in a murine model of sickle cell disease. Nandedkar SD, Feroah TR, Hutchins W, Weihrauch D, Konduri KS, Wang J, Strunk RC, DeBaun MR, Hillery CA, Pritchard KA (2008) Blood 112: 2529-38 Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation. Johnson MC, Kirkham FJ, Redline S, Rosen CL, Yan Y, Roberts I, Gruenwald J, Marek J, DeBaun MR (2010) Blood 116: 16-21 Characterization and quantitation of the circulating forms of serum transferrin receptor using domain-specific antibodies. Shih YJ, Baynes RD, Hudson BG, Cook JD (1993) Blood 81: 234-8 Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia. DeBaun MR, Armstrong FD, McKinstry RC, Ware RE, Vichinsky E, Kirkham FJ (2012) Blood 119: 4587-96 Smoking is associated with an increased risk of acute chest syndrome and pain among adults with sickle cell disease. Cohen RT, DeBaun MR, Blinder MA, Strunk RC, Field JJ (2010) Blood 115: 3852-4 Genome-wide association study to identify variants associated with acute severe vaso-occlusive pain in sickle cell anemia. Chaturvedi S, Bhatnagar P, Bean CJ, Steinberg MH, Milton JN, Casella JF, Barron-Casella E, Arking DE, DeBaun MR (2017) Blood 130: 686-688 Increased susceptibility of the sickle cell membrane Ca2+ + Mg(2+)-ATPase to t-butylhydroperoxide: protective effects of ascorbate and desferal. Moore RB, Hulgan TM, Green JW, Jenkins LD (1992) Blood 79: 1334-41 Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. DeBaun MR, Sarnaik SA, Rodeghier MJ, Minniti CP, Howard TH, Iyer RV, Inusa B, Telfer PT, Kirby-Allen M, Quinn CT, Bernaudin F, Airewele G, Woods GM, Panepinto JA, Fuh B, Kwiatkowski JK, King AA, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Sabio H, Gonzalez CE, Saccente SL, Kalinyak KA, Strouse JJ, Fixler JM, Gordon MO, Miller JP, Noetzel MJ, Ichord RN, Casella JF (2012) Blood 119: 3684-90 Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease. Pegelow CH, Macklin EA, Moser FG, Wang WC, Bello JA, Miller ST, Vichinsky EP, DeBaun MR, Guarini L, Zimmerman RA, Younkin DP, Gallagher DM, Kinney TR (2002) Blood 99: 3014-8 Reversible posterior leukoencephalopathy syndrome and silent cerebral infarcts are associated with severe acute chest syndrome in children with sickle cell disease. Henderson JN, Noetzel MJ, McKinstry RC, White DA, Armstrong M, DeBaun MR (2003) Blood 101: 415-9 Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease. Bean CJ, Boulet SL, Ellingsen D, Pyle ME, Barron-Casella EA, Casella JF, Payne AB, Driggers J, Trau HA, Yang G, Jones K, Ofori-Acquah SF, Hooper WC, DeBaun MR (2012) Blood 120: 3822-8 How I treat and manage strokes in sickle cell disease. Kassim AA, Galadanci NA, Pruthi S, DeBaun MR (2015) Blood 125: 3401-10 Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia. Boyd JH, Macklin EA, Strunk RC, DeBaun MR (2006) Blood 108: 2923-7 Silent cerebral infarcts and cerebral aneurysms are prevalent in adults with sickle cell anemia. Kassim AA, Pruthi S, Day M, Rodeghier M, Gindville MC, Brodsky MA, DeBaun MR, Jordan LC (2016) Blood 127: 2038-40 Time to recognize an overlooked trait. Cavanaugh KL, Lanzkron S (2010) J Am Soc Nephrol 21: 385-6 Poor school and cognitive functioning with silent cerebral infarcts and sickle cell disease. Schatz J, Brown RT, Pascual JM, Hsu L, DeBaun MR (2001) Neurology 56: 1109-11 A pilot randomized education rehabilitation trial is feasible in sickle cell and strokes. King AA, White DA, McKinstry RC, Noetzel M, Debaun MR (2007) Neurology 68: 2008-11 Cognitive screening examinations for silent cerebral infarcts in sickle cell disease. DeBaun MR, Schatz J, Siegel MJ, Koby M, Craft S, Resar L, Chu JY, Launius G, Dadash-Zadeh M, Lee RB, Noetzel M (1998) Neurology 50: 1678-82 Decreased apolipoprotein A-I and B content in plasma of individuals with sickle cell anemia. Sasaki J, Waterman MR, Cottam GL (1986) Clin Chem 32: 226-7 Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin. Pestina TI, Hargrove PW, Jay D, Gray JT, Boyd KM, Persons DA (2009) Mol Ther 17: 245-52 Equation to estimate resting energy expenditure in adolescents with sickle cell anemia. Buchowski MS, Chen KY, Byrne D, Wang WC (2002) Am J Clin Nutr 76: 1335-44 Protein turnover and energy expenditure increase during exogenous nutrient availability in sickle cell disease. Borel MJ, Buchowski MS, Turner EA, Goldstein RE, Flakoll PJ (1998) Am J Clin Nutr 68: 607-14 Cerebral infarction in sickle cell disease: transcranial Doppler US versus neurologic examination. Siegel MJ, Luker GD, Glauser TA, DeBaun MR (1995) Radiology 197: 191-4 Sickle cell disease: imaging of cerebrovascular complications. Moran CJ, Siegel MJ, DeBaun MR (1998) Radiology 206: 311-21 Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Lebensburger JD, Pestina TI, Ware RE, Boyd KL, Persons DA (2010) Haematologica 95: 1599-603 Asthma is associated with acute chest syndrome, but not with an increased rate of hospitalization for pain among children in France with sickle cell anemia: a retrospective cohort study. Bernaudin F, Strunk RC, Kamdem A, Arnaud C, An P, Torres M, Delacourt C, DeBaun MR (2008) Haematologica 93: 1917-8 Excess of heme induces tissue factor-dependent activation of coagulation in mice. Sparkenbaugh EM, Chantrathammachart P, Wang S, Jonas W, Kirchhofer D, Gailani D, Gruber A, Kasthuri R, Key NS, Mackman N, Pawlinski R (2015) Haematologica 100: 308-14
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