Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V (1997) Science 277: 225-8 Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. McCaffrey LM, Montalbano J, Mihai C, Macara IG (2012) Cancer Cell 22: 601-14 LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Wang J, An H, Mayo MW, Baldwin AS, Yarbrough WG (2007) Cancer Cell 12: 239-51 Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DP, Lin PC (2004) Cancer Cell 6: 409-21 Relations of plasma matrix metalloproteinase-9 to clinical cardiovascular risk factors and echocardiographic left ventricular measures: the Framingham Heart Study. Sundström J, Evans JC, Benjamin EJ, Levy D, Larson MG, Sawyer DB, Siwik DA, Colucci WS, Sutherland P, Wilson PW, Vasan RS (2004) Circulation 109: 2850-6 ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY (2011) Dev Cell 21: 746-57 Antimetastatic role of Smad4 signaling in colorectal cancer. Zhang B, Halder SK, Kashikar ND, Cho YJ, Datta A, Gorden DL, Datta PK (2010) Gastroenterology 138: 969-80.e1-3 IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells. Wadsworth SJ, Atsuta R, McIntyre JO, Hackett TL, Singhera GK, Dorscheid DR (2010) J Allergy Clin Immunol 126: 366-74, 374.e1-8 Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching. Johnson C, Sung HJ, Lessner SM, Fini ME, Galis ZS (2004) Circ Res 94: 262-8 VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue. Christoffersson G, Vågesjö E, Vandooren J, Lidén M, Massena S, Reinert RB, Brissova M, Powers AC, Opdenakker G, Phillipson M (2012) Blood 120: 4653-62 TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy. Kim H, Oda T, López-Guisa J, Wing D, Edwards DR, Soloway PD, Eddy AA (2001) J Am Soc Nephrol 12: 736-48 Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Martin MD, Carter KJ, Jean-Philippe SR, Chang M, Mobashery S, Thiolloy S, Lynch CC, Matrisian LM, Fingleton B (2008) Cancer Res 68: 6251-9 Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction. Nicoud IB, Jones CM, Pierce JM, Earl TM, Matrisian LM, Chari RS, Gorden DL (2007) Cancer Res 67: 2720-8 Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Acuff HB, Carter KJ, Fingleton B, Gorden DL, Matrisian LM (2006) Cancer Res 66: 259-66 Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. Deryugina EI, Zijlstra A, Partridge JJ, Kupriyanova TA, Madsen MA, Papagiannakopoulos T, Quigley JP (2005) Cancer Res 65: 10959-69 Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, Geng Y, Gray JW, Moses HL, Yang L (2010) Cancer Res 70: 6139-49 Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Thiolloy S, Halpern J, Holt GE, Schwartz HS, Mundy GR, Matrisian LM, Lynch CC (2009) Cancer Res 69: 6747-55 Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility. Mott JD, Khalifah RG, Nagase H, Shield CF, Hudson JK, Hudson BG (1997) Kidney Int 52: 1302-12 Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Ma LJ, Jha S, Ling H, Pozzi A, Ledbetter S, Fogo AB (2004) Kidney Int 65: 106-15 Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Kang L, Ayala JE, Lee-Young RS, Zhang Z, James FD, Neufer PD, Pozzi A, Zutter MM, Wasserman DH (2011) Diabetes 60: 416-26 Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy. Fingleton B, Menon R, Carter KJ, Overstreet PD, Hachey DL, Matrisian LM, McIntyre JO (2004) Clin Cancer Res 10: 7865-74 Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. Solorzano CC, Hwang R, Baker CH, Bucana CD, Pisters PW, Evans DB, Killion JJ, Fidler IJ (2003) Clin Cancer Res 9: 1858-67 Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels. Zachman AL, Wang X, Tucker-Schwartz JM, Fitzpatrick ST, Lee SH, Guelcher SA, Skala MC, Sung HJ (2014) Biomaterials 35: 9635-48 Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis. Pozzi A, LeVine WF, Gardner HA (2002) Oncogene 21: 272-81 Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition. Biolo A, Ramamurthy S, Connors LH, O'Hara CJ, Meier-Ewert HK, Soo Hoo PT, Sawyer DB, Seldin DC, Seldin DS, Sam F (2008) Circ Heart Fail 1: 249-57 Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice. Kang L, Mayes WH, James FD, Bracy DP, Wasserman DH (2014) Diabetologia 57: 603-13 A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. Chu X, Filali M, Stanic B, Takapoo M, Sheehan A, Bhalla R, Lamb FS, Miller FJ (2011) Arterioscler Thromb Vasc Biol 31: 345-51 Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A (2005) Int J Cancer 116: 52-61 Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment. Gorden DL, Fingleton B, Crawford HC, Jansen DE, Lepage M, Matrisian LM (2007) Int J Cancer 121: 495-500 Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study. Kelly PJ, Morrow JD, Ning M, Koroshetz W, Lo EH, Terry E, Milne GL, Hubbard J, Lee H, Stevenson E, Lederer M, Furie KL (2008) Stroke 39: 100-4 Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone. Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O'Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR (2011) J Bone Miner Res 26: 1252-60 Elucidation of adhesion-dependent spontaneous apoptosis in macrophages using phase separated PEG/polyurethane films. Zachman AL, Page JM, Prabhakar G, Guelcher SA, Sung HJ (2013) Acta Biomater 9: 4964-75 Comparison of protein immunoprecipitation-multiple reaction monitoring with ELISA for assay of biomarker candidates in plasma. Lin D, Alborn WE, Slebos RJ, Liebler DC (2013) J Proteome Res 12: 5996-6003 Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitus. Fowlkes JL, Bunn RC, Liu L, Wahl EC, Coleman HN, Cockrell GE, Perrien DS, Lumpkin CK, Thrailkill KM (2008) Endocrinology 149: 1697-704 Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells. Halder SK, Osteen KG, Al-Hendy A (2013) Hum Reprod 28: 2407-16 Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages. Pavlovic S, Du B, Sakamoto K, Khan KM, Natarajan C, Breyer RM, Dannenberg AJ, Falcone DJ (2006) J Biol Chem 281: 3321-8 Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen. Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (2001) J Biol Chem 276: 29368-74 Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. Shiou SR, Datta PK, Dhawan P, Law BK, Yingling JM, Dixon DA, Beauchamp RD (2006) J Biol Chem 281: 33971-81 Synthesis and in vitro efficacy of MMP9-activated NanoDendrons. Samuelson LE, Scherer RL, Matrisian LM, McIntyre JO, Bornhop DJ (2013) Mol Pharm 10: 3164-74 MMP9 polymorphisms and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study. Beeghly-Fadiel A, Lu W, Shu XO, Long J, Cai Q, Xiang Y, Gao YT, Zheng W (2011) Breast Cancer Res Treat 126: 507-13
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