Keyword Connections

•  Mark de Caestecker

•  Timothy Blackwell

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• de Caestecker Lab

Publications

• Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding.
  Ito M, Yang Z, Andl T, Cui C, Kim N, Millar SE, Cotsarelis G
  (2007) Nature 447: 316-20
• Organization and execution of the epithelial polarity programme.
  Rodriguez-Boulan E, Macara IG
  (2014) Nat Rev Mol Cell Biol 15: 225-42
• Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling.
  Yang SH, Andl T, Grachtchouk V, Wang A, Liu J, Syu LJ, Ferris J, Wang TS, Glick AB, Millar SE, Dlugosz AA
  (2008) Nat Genet 40: 1130-5
• TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights.
  Moses HL, Yang EY, Pietenpol JA
  (1990) Cell 63: 245-7
• Under pressure: stromal fibroblasts change their ways.
  Bierie B, Moses HL
  (2005) Cell 123: 985-7
• Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5.
  Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V
  (1997) Science 277: 225-8
• Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion.
  Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Bäumler AJ
  (2017) Science 357: 570-575
• TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.
  Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG, Moses HL
  (2004) Science 303: 848-51
• Forces for morphogenesis investigated with laser microsurgery and quantitative modeling.
  Hutson MS, Tokutake Y, Chang MS, Bloor JW, Venakides S, Kiehart DP, Edwards GS
  (2003) Science 300: 145-9
• Role of innate immunity in Helicobacter pylori-induced gastric malignancy.
  Peek RM, Fiske C, Wilson KT
  (2010) Physiol Rev 90: 831-58
• Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition.
  Acevedo VD, Gangula RD, Freeman KW, Li R, Zhang Y, Wang F, Ayala GE, Peterson LE, Ittmann M, Spencer DM
  (2007) Cancer Cell 12: 559-71
• EGF receptor is required for KRAS-induced pancreatic tumorigenesis.
  Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT
  (2012) Cancer Cell 22: 304-17
• mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
  Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM
  (2009) Cancer Cell 15: 148-59
• Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury.
  Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV
  (2010) Nat Med 16: 535-43, 1p following 143
• Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus.
  Borza CM, Hutt-Fletcher LM
  (2002) Nat Med 8: 594-9
• Helicobacter pylori VacA, a paradigm for toxin multifunctionality.
  Cover TL, Blanke SR
  (2005) Nat Rev Microbiol 3: 320-32
• A role for actin arcs in the leading-edge advance of migrating cells.
  Burnette DT, Manley S, Sengupta P, Sougrat R, Davidson MW, Kachar B, Lippincott-Schwartz J
  (2011) Nat Cell Biol 13: 371-81
• EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
  Löf-Öhlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H
  (2017) Nat Cell Biol 19: 1313-1325
• Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells.
  Singh B, Coffey RJ
  (2014) Annu Rev Physiol 76: 275-300
• Gastrointestinal carcinoma antigen GA733: target for immunodestruction and potential modifier of invasiveness and chemoresponsiveness.
  Zutter MM
  (1998) J Natl Cancer Inst 90: 642-4
• Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice.
  Fleeton MN, Contractor N, Leon F, Wetzel JD, Dermody TS, Kelsall BL
  (2004) J Exp Med 200: 235-45
• Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells.
  Wu M, van Kaer L, Itohara S, Tonegawa S
  (1991) J Exp Med 174: 213-8
• The PAR proteins: fundamental players in animal cell polarization.
  Goldstein B, Macara IG
  (2007) Dev Cell 13: 609-622
• Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.
  Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G, Grapin-Botton A
  (2007) Dev Cell 12: 457-65
• ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation.
  Crawley SW, Weck ML, Grega-Larson NE, Shifrin DA, Tyska MJ
  (2016) Dev Cell 36: 190-200
• PTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarity.
  Andreeva A, Lee J, Lohia M, Wu X, Macara IG, Lu X
  (2014) Dev Cell 29: 20-33
• MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis.
  Rebustini IT, Myers C, Lassiter KS, Surmak A, Szabova L, Holmbeck K, Pedchenko V, Hudson BG, Hoffman MP
  (2009) Dev Cell 17: 482-93
• Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland.
  Davis MA, Reynolds AB
  (2006) Dev Cell 10: 21-31
• Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family.
  Wei J, O'Brien D, Vilgelm A, Piazuelo MB, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika A
  (2008) Gastroenterology 134: 1412-23
• Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth.
  Yan F, Cao H, Cover TL, Whitehead R, Washington MK, Polk DB
  (2007) Gastroenterology 132: 562-75
• Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice.
  Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T
  (2010) Gastroenterology 139: 987-98
• Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.
  Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM, Cover TL, Washington MK, Wilson KT, Polk DB
  (2009) Gastroenterology 136: 1297-1307, e1-3
• Regulation of pancreas plasticity and malignant transformation by Akt signaling.
  Elghazi L, Weiss AJ, Barker DJ, Callaghan J, Staloch L, Sandgren EP, Gannon M, Adsay VN, Bernal-Mizrachi E
  (2009) Gastroenterology 136: 1091-103
• N-methyl D-aspartate channels link ammonia and epithelial cell death mechanisms in Helicobacter pylori Infection.
  Seo JH, Fox JG, Peek RM, Hagen SJ
  (2011) Gastroenterology 141: 2064-75
• Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils.
  Peek RM, Wirth HP, Moss SF, Yang M, Abdalla AM, Tham KT, Zhang T, Tang LH, Modlin IM, Blaser MJ
  (2000) Gastroenterology 118: 48-59
• Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.
  Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV, Coffey RJ, Leach SD
  (2003) Gastroenterology 124: 1020-36
• It's about time: clock genes unveiled in the gut.
  Scheving LA, Russell WE
  (2007) Gastroenterology 133: 1373-6
• β-Catenin and p120 mediate PPARδ-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia.
  Nagy TA, Wroblewski LE, Wang D, Piazuelo MB, Delgado A, Romero-Gallo J, Noto J, Israel DA, Ogden SR, Correa P, Cover TL, Peek RM
  (2011) Gastroenterology 141: 553-64
• Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA.
  Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KT
  (2011) Gastroenterology 141: 1696-708.e1-2
• Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage.
  Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Wilson KT
  (2014) Gastroenterology 146: 1739-51.e14