Growth retardation and tumour inhibition by BRCA1. Holt JT, Thompson ME, Szabo C, Robinson-Benion C, Arteaga CL, King MC, Jensen RA (1996) Nat Genet 12: 298-302 Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V, Arteaga CL (2002) J Clin Invest 109: 1551-9 Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer. Dushyanthen S, Teo ZL, Caramia F, Savas P, Mintoff CP, Virassamy B, Henderson MA, Luen SJ, Mansour M, Kershaw MH, Trapani JA, Neeson PJ, Salgado R, McArthur GA, Balko JM, Beavis PA, Darcy PK, Loi S (2017) Nat Commun 8: 606 Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. Owens P, Pickup MW, Novitskiy SV, Chytil A, Gorska AE, Aakre ME, West J, Moses HL (2012) Proc Natl Acad Sci U S A 109: 2814-9 Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor. Lynch CC, Vargo-Gogola T, Martin MD, Fingleton B, Crawford HC, Matrisian LM (2007) Cancer Res 67: 6760-7 Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Aslakson CJ, Miller FR (1992) Cancer Res 52: 1399-405 PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses. Sai J, Owens P, Novitskiy SV, Hawkins OE, Vilgelm AE, Yang J, Sobolik T, Lavender N, Johnson AC, McClain C, Ayers GD, Kelley MC, Sanders M, Mayer IA, Moses HL, Boothby M, Richmond A (2017) Clin Cancer Res 23: 3371-3384 Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Cheng N, Bhowmick NA, Chytil A, Gorksa AE, Brown KA, Muraoka R, Arteaga CL, Neilson EG, Hayward SW, Moses HL (2005) Oncogene 24: 5053-68 Inhibition of BMP signaling suppresses metastasis in mammary cancer. Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, Hong CC, Moses HL (2015) Oncogene 34: 2437-49 Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Connelly L, Barham W, Onishko HM, Sherrill T, Chodosh LA, Blackwell TS, Yull FE (2011) Oncogene 30: 1402-12 Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, Zent R, Arteaga CL (2006) Oncogene 25: 3408-23 Biocompatible mannosylated endosomal-escape nanoparticles enhance selective delivery of short nucleotide sequences to tumor associated macrophages. Ortega RA, Barham WJ, Kumar B, Tikhomirov O, McFadden ID, Yull FE, Giorgio TD (2015) Nanoscale 7: 500-10 Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. Brantley-Sieders DM, Fang WB, Hicks DJ, Zhuang G, Shyr Y, Chen J (2005) FASEB J 19: 1884-6 Role of TGF-β signaling in generation of CD39+CD73+ myeloid cells in tumors. Ryzhov SV, Pickup MW, Chytil A, Gorska AE, Zhang Q, Owens P, Feoktistov I, Moses HL, Novitskiy SV (2014) J Immunol 193: 3155-64 Genomic and proteomic analysis of mammary tumors arising in transgenic mice. Xie L, Xu BJ, Gorska AE, Shyr Y, Schwartz SA, Cheng N, Levy S, Bierie B, Caprioli RM, Moses HL (2005) J Proteome Res 4: 2088-98 Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation. Gorska AE, Jensen RA, Shyr Y, Aakre ME, Bhowmick NA, Moses HL (2003) Am J Pathol 163: 1539-49 VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson RS (2010) Am J Pathol 176: 2269-82 Migration of breast epithelial cells on Laminin-5: differential role of integrins in normal and transformed cell types. Plopper GE, Domanico SZ, Cirulli V, Kiosses WB, Quaranta V (1998) Breast Cancer Res Treat 51: 57-69 Characterization of the MDSC proteome associated with metastatic murine mammary tumors using label-free mass spectrometry and shotgun proteomics. Boutté AM, McDonald WH, Shyr Y, Yang L, Lin PC (2011) PLoS One 6: e22446 Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. Owens P, Polikowsky H, Pickup MW, Gorska AE, Jovanovic B, Shaw AK, Novitskiy SV, Hong CC, Moses HL (2013) PLoS One 8: e67533 Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression. Fang WB, Jokar I, Chytil A, Moses HL, Abel T, Cheng N (2011) Clin Exp Metastasis 28: 351-66 Coregistration of ultrasonography and magnetic resonance imaging with a preliminary investigation of the spatial colocalization of vascular endothelial growth factor receptor 2 expression and tumor perfusion in a murine tumor model. Loveless ME, Whisenant JG, Wilson K, Lyshchik A, Sinha TK, Gore JC, Yankeelov TE (2009) Mol Imaging 8: 187-98 Bioluminescence imaging of vascular endothelial growth factor promoter activity in murine mammary tumorigenesis. Faley SL, Takahashi K, Crooke CE, Beckham JT, Tomemori T, Shappell SB, Jansen ED, Takahashi T (2007) Mol Imaging 6: 331-9 Quantitative [F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+ Breast Cancer. Sorace AG, Syed AK, Barnes SL, Quarles CC, Sanchez V, Kang H, Yankeelov TE (2017) Mol Imaging Biol 19: 130-137 Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T. Yankeelov TE, DeBusk LM, Billheimer DD, Luci JJ, Lin PC, Price RR, Gore JC (2006) J Magn Reson Imaging 24: 1140-7 The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Hulboy DL, Gautam S, Fingleton B, Matrisian LM (2004) Oncol Rep 12: 13-7 An In Vivo Gain-of-Function Screen Identifies the Williams-Beuren Syndrome Gene GTF2IRD1 as a Mammary Tumor Promoter. Huo Y, Su T, Cai Q, Macara IG (2016) Cell Rep 15: 2089-2096
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