Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases. Rouzer CA, Marnett LJ (2003) Chem Rev 103: 2239-304 Free radical oxidation of polyunsaturated lipids: New mechanistic insights and the development of peroxyl radical clocks. Pratt DA, Tallman KA, Porter NA (2011) Acc Chem Res 44: 458-67 Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation. Gao W, Washington MK, Bentley RC, Clavien PA (1997) Gastroenterology 113: 1692-700 Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors. Takahashi K, Nammour TM, Fukunaga M, Ebert J, Morrow JD, Roberts LJ, Hoover RL, Badr KF (1992) J Clin Invest 90: 136-41 Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. King LS, Fukushima M, Banerjee M, Kang KH, Newman JH, Biaggioni I (1991) Circ Res 68: 352-8 Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations. Lamberson CR, Xu L, Muchalski H, Montenegro-Burke JR, Shmanai VV, Bekish AV, McLean JA, Clarke CF, Shchepinov MS, Porter NA (2014) J Am Chem Soc 136: 838-41 Factors influencing the autoxidation of fatty acids: effect of olefin geometry of the nonconjugated diene. Tallman KA, Roschek B, Porter NA (2004) J Am Chem Soc 126: 9240-7 Rate constants for peroxidation of polyunsaturated fatty acids and sterols in solution and in liposomes. Xu L, Davis TA, Porter NA (2009) J Am Chem Soc 131: 13037-44 ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations. Beavers WN, Serwa R, Shimozu Y, Tallman KA, Vaught M, Dalvie ED, Marnett LJ, Porter NA (2014) J Am Chem Soc 136: 11529-39 Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis. Daniel TO, Liu H, Morrow JD, Crews BC, Marnett LJ (1999) Cancer Res 59: 4574-7 Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Graves PR, Lovly CM, Uy GL, Piwnica-Worms H (2001) Oncogene 20: 1839-51 New insights regarding the autoxidation of polyunsaturated fatty acids. Yin H, Porter NA (2005) Antioxid Redox Signal 7: 170-84 Erythrocyte fatty acid composition and the metabolic syndrome: a National Heart, Lung, and Blood Institute GOLDN study. Kabagambe EK, Tsai MY, Hopkins PN, Ordovas JM, Peacock JM, Borecki IB, Arnett DK (2008) Clin Chem 54: 154-62 Manipulation of maternal diet to alter fatty acid composition of human milk intended for premature infants. Silber GH, Hachey DL, Schanler RJ, Garza C (1988) Am J Clin Nutr 47: 810-4 Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome. Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM (2009) Am J Clin Nutr 90: 1665-73 Adipose tissue biomarkers of fatty acid intake. Baylin A, Kabagambe EK, Siles X, Campos H (2002) Am J Clin Nutr 76: 750-7 Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites. Harris RC, Munger KA, Badr KF, Takahashi K (1990) FASEB J 4: 1654-60 Determining Double Bond Position in Lipids Using Online Ozonolysis Coupled to Liquid Chromatography and Ion Mobility-Mass Spectrometry. Harris RA, May JC, Stinson CA, Xia Y, McLean JA (2018) Anal Chem 90: 1915-1924 Regulation of the rapsyn promoter by kaiso and delta-catenin. Rodova M, Kelly KF, VanSaun M, Daniel JM, Werle MJ (2004) Mol Cell Biol 24: 7188-96 Spin trapping of polyunsaturated fatty acid-derived peroxyl radicals: reassignment to alkoxyl radical adducts. Dikalov SI, Mason RP (2001) Free Radic Biol Med 30: 187-97 Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells. Omata Y, Saito Y, Yoshida Y, Jeong BS, Serwa R, Nam TG, Porter NA, Niki E (2010) Free Radic Biol Med 48: 1358-65 Ascorbate 6-palmitate protects human erythrocytes from oxidative damage. Ross D, Mendiratta S, Qu ZC, Cobb CE, May JM (1999) Free Radic Biol Med 26: 81-9 Application of the method of triads to evaluate the performance of food frequency questionnaires and biomarkers as indicators of long-term dietary intake. Kabagambe EK, Baylin A, Allan DA, Siles X, Spiegelman D, Campos H (2001) Am J Epidemiol 154: 1126-35 Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids. Zheng Y, Brash AR (2010) J Biol Chem 285: 39866-75 Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells. Kühn H, Brash AR (1990) J Biol Chem 265: 1454-8 Oxygenation of biological membranes by the pure reticulocyte lipoxygenase. Kuhn H, Belkner J, Wiesner R, Brash AR (1990) J Biol Chem 265: 18351-61 The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. Capdevila JH, Wei S, Helvig C, Falck JR, Belosludtsev Y, Truan G, Graham-Lorence SE, Peterson JA (1996) J Biol Chem 271: 22663-71 Arachidonic acid metabolism in rabbit renal cortex. Formation of two novel dihydroxyeicosatrienoic acids. Oliw EH, Lawson JA, Brash AR, Oates JA (1981) J Biol Chem 256: 9924-31 CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. Leskov KS, Araki S, Lavik JP, Gomez JA, Gama V, Gonos ES, Trougakos IP, Matsuyama S, Boothman DA (2011) J Biol Chem 286: 40083-90 Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. Plastaras JP, Guengerich FP, Nebert DW, Marnett LJ (2000) J Biol Chem 275: 11784-90 Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils. Serezani CH, Aronoff DM, Jancar S, Peters-Golden M (2005) J Leukoc Biol 78: 976-84 Inflammation and cancer: chemical approaches to mechanisms, imaging, and treatment. Marnett LJ (2012) J Org Chem 77: 5224-38 A perspective on free radical autoxidation: the physical organic chemistry of polyunsaturated fatty acid and sterol peroxidation. Porter NA (2013) J Org Chem 78: 3511-24 A prospective study of dietary polyunsaturated fatty acids and colorectal cancer risk in Chinese women. Murff HJ, Shu XO, Li H, Dai Q, Kallianpur A, Yang G, Cai H, Wen W, Gao YT, Zheng W (2009) Cancer Epidemiol Biomarkers Prev 18: 2283-91 Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells. Huang J, de Paulis T, May JM (2004) J Nutr Biochem 15: 722-9 Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. Nieman DC, Henson DA, Maxwell KR, Williams AS, McAnulty SR, Jin F, Shanely RA, Lines TC (2009) Med Sci Sports Exerc 41: 1467-75 Isoprostanes. Roberts LJ, Milne GL (2009) J Lipid Res 50 Suppl: S219-23 Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha. Matsuzaka T, Shimano H, Yahagi N, Amemiya-Kudo M, Yoshikawa T, Hasty AH, Tamura Y, Osuga J, Okazaki H, Iizuka Y, Takahashi A, Sone H, Gotoda T, Ishibashi S, Yamada N (2002) J Lipid Res 43: 107-14 Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. Matsuzaka T, Shimano H, Yahagi N, Yoshikawa T, Amemiya-Kudo M, Hasty AH, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Takahashi A, Yato S, Sone H, Ishibashi S, Yamada N (2002) J Lipid Res 43: 911-20 Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome. Windsor K, Genaro-Mattos TC, Kim HY, Liu W, Tallman KA, Miyamoto S, Korade Z, Porter NA (2013) J Lipid Res 54: 2842-50
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.