CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q, Richmond A, Strieter R, Dey SK, DuBois RN (2006) J Exp Med 203: 941-51 Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. Mei J, Liu Y, Dai N, Hoffmann C, Hudock KM, Zhang P, Guttentag SH, Kolls JK, Oliver PM, Bushman FD, Worthen GS (2012) J Clin Invest 122: 974-86 Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, Moses HL (2011) J Clin Invest 121: 4106-17 Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F (2018) Cell Host Microbe 23: 203-214.e5 Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. Reyes-Robles T, Alonzo F, Kozhaya L, Lacy DB, Unutmaz D, Torres VJ (2013) Cell Host Microbe 14: 453-9 Differential regulation of CXCR2 trafficking by Rab GTPases. Fan GH, Lapierre LA, Goldenring JR, Richmond A (2003) Blood 101: 2115-24 Opposing roles of murine duffy antigen receptor for chemokine and murine CXC chemokine receptor-2 receptors in murine melanoma tumor growth. Horton LW, Yu Y, Zaja-Milatovic S, Strieter RM, Richmond A (2007) Cancer Res 67: 9791-9 Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins. Owen JD, Strieter R, Burdick M, Haghnegahdar H, Nanney L, Shattuck-Brandt R, Richmond A (1997) Int J Cancer 73: 94-103 Delayed wound healing in CXCR2 knockout mice. Devalaraja RM, Nanney LB, Du J, Qian Q, Yu Y, Devalaraja MN, Richmond A (2000) J Invest Dermatol 115: 234-44 VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. Neel NF, Barzik M, Raman D, Sobolik-Delmaire T, Sai J, Ham AJ, Mernaugh RL, Gertler FB, Richmond A (2009) J Cell Sci 122: 1882-94 The C-terminal domain LLKIL motif of CXCR2 is required for ligand-mediated polarization of early signals during chemotaxis. Sai J, Fan GH, Wang D, Richmond A (2004) J Cell Sci 117: 5489-96 RhoB plays an essential role in CXCR2 sorting decisions. Neel NF, Lapierre LA, Goldenring JR, Richmond A (2007) J Cell Sci 120: 1559-71 The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions. Raghuwanshi SK, Su Y, Singh V, Haynes K, Richmond A, Richardson RM (2012) J Immunol 189: 2824-32 The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. Addison CL, Daniel TO, Burdick MD, Liu H, Ehlert JE, Xue YY, Buechi L, Walz A, Richmond A, Strieter RM (2000) J Immunol 165: 5269-77 Altered CXCR2 signaling in beta-arrestin-2-deficient mouse models. Su Y, Raghuwanshi SK, Yu Y, Nanney LB, Richardson RM, Richmond A (2005) J Immunol 175: 5396-402 Adaptor protein2 (AP2) orchestrates CXCR2-mediated cell migration. Raman D, Sai J, Hawkins O, Richmond A (2014) Traffic 15: 451-69 The IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells. Sai J, Walker G, Wikswo J, Richmond A (2006) J Biol Chem 281: 35931-41 Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and trafficking. Fan GH, Yang W, Sai J, Richmond A (2002) J Biol Chem 277: 6590-7 Phosphorylation-independent association of CXCR2 with the protein phosphatase 2A core enzyme. Fan GH, Yang W, Sai J, Richmond A (2001) J Biol Chem 276: 16960-8 Role of clathrin-mediated endocytosis in CXCR2 sequestration, resensitization, and signal transduction. Yang W, Wang D, Richmond A (1999) J Biol Chem 274: 11328-33 Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. Mueller SG, White JR, Schraw WP, Lam V, Richmond A (1997) J Biol Chem 272: 8207-14 Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis. Sai J, Raman D, Liu Y, Wikswo J, Richmond A (2008) J Biol Chem 283: 26538-47 The carboxyl-terminal PDZ ligand motif of chemokine receptor CXCR2 modulates post-endocytic sorting and cellular chemotaxis. Baugher PJ, Richmond A (2008) J Biol Chem 283: 30868-78 Increased drug affinity as the mechanistic basis for drug hypersensitivity of a mutant type II topoisomerase. Froelich-Ammon SJ, Burden DA, Patchan MW, Elsea SH, Thompson RB, Osheroff N (1995) J Biol Chem 270: 28018-21 CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways. Sobolik T, Su YJ, Wells S, Ayers GD, Cook RS, Richmond A (2014) Mol Biol Cell 25: 566-82 Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis. Fan GH, Lapierre LA, Goldenring JR, Sai J, Richmond A (2004) Mol Biol Cell 15: 2456-69 Short tail with skin lesion phenotype occurs in transgenic mice with keratin-14 promoter-directed expression of mutant CXCR2. Yu Y, Su Y, Opalenik SR, Sobolik-Delmaire T, Neel NF, Zaja-Milatovic S, Short ST, Sai J, Richmond A (2008) J Leukoc Biol 84: 406-19 Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress. Du J, Luan J, Liu H, Daniel TO, Peiper S, Chen TS, Yu Y, Horton LW, Nanney LB, Strieter RM, Richmond A (2002) J Leukoc Biol 71: 141-53 The role of MyD88- and TRIF-dependent signaling in monophosphoryl lipid A-induced expansion and recruitment of innate immunocytes. Hernandez A, Bohannon JK, Luan L, Fensterheim BA, Guo Y, Patil NK, McAdams C, Wang J, Sherwood ER (2016) J Leukoc Biol 100: 1311-1322 Distributions of melanoma growth stimulatory activity of growth-regulated gene and the interleukin-8 receptor B in human wound repair. Nanney LB, Mueller SG, Bueno R, Peiper SC, Richmond A (1995) Am J Pathol 147: 1248-60 Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity. Raman D, Milatovic SZ, Milatovic D, Splittgerber R, Fan GH, Richmond A (2011) Toxicol Appl Pharmacol 256: 300-13 LIM and SH3 protein-1 modulates CXCR2-mediated cell migration. Raman D, Sai J, Neel NF, Chew CS, Richmond A (2010) PLoS One 5: e10050 Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitment. Das ST, Rajagopalan L, Guerrero-Plata A, Sai J, Richmond A, Garofalo RP, Rajarathnam K (2010) PLoS One 5: e11754 IQGAP1 is a novel CXCR2-interacting protein and essential component of the "chemosynapse". Neel NF, Sai J, Ham AJ, Sobolik-Delmaire T, Mernaugh RL, Richmond A (2011) PLoS One 6: e23813 Cell surface heparan sulfate participates in CXCL1-induced signaling. Wang D, Sai J, Richmond A (2003) Biochemistry 42: 1071-7 Interruption of G protein-coupling in CXCR2 does not alter ligand binding, but eliminates ligand-activation of GTPgamma35S binding, calcium mobilization, and chemotaxis. Yang W, Schraw WP, Mueller SG, Richmond A (1997) Biochemistry 36: 15193-200 Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization. Fan GH, Yang W, Wang XJ, Qian Q, Richmond A (2001) Biochemistry 40: 791-800 Functional characterization of chimpanzee cytomegalovirus chemokine, vCXCL-1(CCMV). Miller-Kittrell M, Sai J, Penfold M, Richmond A, Sparer TE (2007) Virology 364: 454-65 Chemokine and chemokine receptor expression in keloid and normal fibroblasts. Nirodi CS, Devalaraja R, Nanney LB, Arrindell S, Russell S, Trupin J, Richmond A (2000) Wound Repair Regen 8: 371-82 Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Milatovic S, Nanney LB, Yu Y, White JR, Richmond A (2003) Wound Repair Regen 11: 213-9
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