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•  Manuel Ascano

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Publications

• Anthracyclines and heart failure.
  Sawyer DB
  (2013) N Engl J Med 368: 1154-6
• Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.
  Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG
  (2017) N Engl J Med 376: 1647-1658
• Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose.
  Chung CH, Mirakhur B, Chan E, Le QT, Berlin J, Morse M, Murphy BA, Satinover SM, Hosen J, Mauro D, Slebos RJ, Zhou Q, Gold D, Hatley T, Hicklin DJ, Platts-Mills TA
  (2008) N Engl J Med 358: 1109-17
• Interactions of carcinogen-bound DNA with individual DNA polymerases.
  Guengerich FP
  (2006) Chem Rev 106: 420-52
• The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
  Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR
  (2012) Nature 492: 285-9
• Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.
  Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN
  (2008) Nature 452: 98-102
• Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.
  Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, Orr HT, Zoghbi HY
  (2008) Nature 452: 713-8
• NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.
  Huang B, Eberstadt M, Olejniczak ET, Meadows RP, Fesik SW
  (1996) Nature 384: 638-41
• Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor.
  Goodman OB, Krupnick JG, Santini F, Gurevich VV, Penn RB, Gagnon AW, Keen JH, Benovic JL
  (1996) Nature 383: 447-50
• Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
  Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW
  (2000) Nature 408: 1004-8
• Integrin-linked kinase is an adaptor with essential functions during mouse development.
  Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R
  (2009) Nature 461: 1002-6
• The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.
  Noel JP, Hamm HE, Sigler PB
  (1993) Nature 366: 654-63
• Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis.
  Bushdid PB, Brantley DM, Yull FE, Blaeuer GL, Hoffman LH, Niswander L, Kerr LD
  (1998) Nature 392: 615-8
• p19ARF directly and differentially controls the functions of c-Myc independently of p53.
  Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR
  (2004) Nature 431: 712-7
• Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.
  Harlan JE, Hajduk PJ, Yoon HS, Fesik SW
  (1994) Nature 371: 168-70
• Regulation of alternative splicing by RNA editing.
  Rueter SM, Dawson TR, Emeson RB
  (1999) Nature 399: 75-80
• Alternative production of calcitonin and CGRP mRNA is regulated at the calcitonin-specific splice acceptor.
  Emeson RB, Hedjran F, Yeakley JM, Guise JW, Rosenfeld MG
  (1989) Nature 341: 76-80
• The 2.0 A crystal structure of a heterotrimeric G protein.
  Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB
  (1996) Nature 379: 311-9
• An unprecedented nucleic acid capture mechanism for excision of DNA damage.
  Rubinson EH, Gowda AS, Spratt TE, Gold B, Eichman BF
  (2010) Nature 468: 406-11
• Regulation of serotonin-2C receptor G-protein coupling by RNA editing.
  Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB
  (1997) Nature 387: 303-8
• DNA bend direction by phase sensitive detection.
  Zinkel SS, Crothers DM
  (1987) Nature 328: 178-81
• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.
  Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS
  (2007) Nature 447: 959-65
• NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
  Tooley CE, Petkowski JJ, Muratore-Schroeder TL, Balsbaugh JL, Shabanowitz J, Sabat M, Minor W, Hunt DF, Macara IG
  (2010) Nature 466: 1125-8
• TFIIA and the transactivator Rap1 cooperate to commit TFIID for transcription initiation.
  Papai G, Tripathi MK, Ruhlmann C, Layer JH, Weil PA, Schultz P
  (2010) Nature 465: 956-60
• Patterns and rates of exonic de novo mutations in autism spectrum disorders.
  Neale BM, Kou Y, Liu L, Ma'ayan A, Samocha KE, Sabo A, Lin CF, Stevens C, Wang LS, Makarov V, Polak P, Yoon S, Maguire J, Crawford EL, Campbell NG, Geller ET, Valladares O, Schafer C, Liu H, Zhao T, Cai G, Lihm J, Dannenfelser R, Jabado O, Peralta Z, Nagaswamy U, Muzny D, Reid JG, Newsham I, Wu Y, Lewis L, Han Y, Voight BF, Lim E, Rossin E, Kirby A, Flannick J, Fromer M, Shakir K, Fennell T, Garimella K, Banks E, Poplin R, Gabriel S, DePristo M, Wimbish JR, Boone BE, Levy SE, Betancur C, Sunyaev S, Boerwinkle E, Buxbaum JD, Cook EH, Devlin B, Gibbs RA, Roeder K, Schellenberg GD, Sutcliffe JS, Daly MJ
  (2012) Nature 485: 242-5
• TBP-associated factors are not generally required for transcriptional activation in yeast.
  Moqtaderi Z, Bai Y, Poon D, Weil PA, Struhl K
  (1996) Nature 383: 188-91
• An RNA-export mediator with an essential nuclear export signal.
  Murphy R, Wente SR
  (1996) Nature 383: 357-60
• Inhibition of nuclear hormone receptor activity by calreticulin.
  Dedhar S, Rennie PS, Shago M, Hagesteijn CY, Yang H, Filmus J, Hawley RG, Bruchovsky N, Cheng H, Matusik RJ
  (1994) Nature 367: 480-3
• Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.
  Litingtung Y, Dahn RD, Li Y, Fallon JF, Chiang C
  (2002) Nature 418: 979-83
• The transcription factor NF-ATc is essential for cardiac valve formation.
  Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH
  (1998) Nature 392: 186-90
• Prostacyclin inhibits mobilisation of fibrinogen-binding sites on human ADP- and thrombin-treated platelets.
  Hawiger J, Parkinson S, Timmons S
  (1980) Nature 283: 195-7
• Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
  Xin HB, Senbonmatsu T, Cheng DS, Wang YX, Copello JA, Ji GJ, Collier ML, Deng KY, Jeyakumar LH, Magnuson MA, Inagami T, Kotlikoff MI, Fleischer S
  (2002) Nature 416: 334-8
• Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
  Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM
  (2001) Nature 413: 131-8
• Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box.
  Horikoshi M, Wang CK, Fujii H, Cromlish JA, Weil PA, Roeder RG
  (1989) Nature 341: 299-303
• Gal4 turnover and transcription activation.
  Collins GA, Lipford JR, Deshaies RJ, Tansey WP
  (2009) Nature 461: E7; discussion E8