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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Ligands are shown below. Double-click or tap a node for more information.
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Publications
- Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, Pardoll DM, Chen L, Sharfman WH, Anders RA, Taube JM, McMiller TL, Xu H, Korman AJ, Jure-Kunkel M, Agrawal S, McDonald D, Kollia GD, Gupta A, Wigginton JM, Sznol M
(2012) N Engl J Med 366: 2443-54 - Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.
Lindsley CW, Emmitte KA, Hopkins CR, Bridges TM, Gregory KJ, Niswender CM, Conn PJ
(2016) Chem Rev 116: 6707-41 - Activation of NMDA receptors and the mechanism of inhibition by ifenprodil.
Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H
(2016) Nature 534: 63-8 - Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
(2012) Nature 487: 505-9 - Leptin regulation of bone resorption by the sympathetic nervous system and CART.
Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G
(2005) Nature 434: 514-20 - Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW
(1995) Nature 378: 584-92 - G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD
(2015) Nature 520: 94-8 - Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.
Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R
(2000) Nature 405: 966-70 - Overview of the Alliance for Cellular Signaling.
Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR, Participating investigators and scientists of the Alliance for Cellular Signaling
(2002) Nature 420: 703-6 - Structural basis of ligand binding modes at the neuropeptide Y Y receptor.
Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B
(2018) Nature 556: 520-524 - Integrated genomic and molecular characterization of cervical cancer.
Cancer Genome Atlas Research Network, Albert Einstein College of Medicine, Analytical Biological Services, Barretos Cancer Hospital, Baylor College of Medicine, Beckman Research Institute of City of Hope, Buck Institute for Research on Aging, Canada's Michael Smith Genome Sciences Centre, Harvard Medical School, Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services, HudsonAlpha Institute for Biotechnology, ILSbio, LLC, Indiana University School of Medicine, Institute of Human Virology, Institute for Systems Biology, International Genomics Consortium, Leidos Biomedical, Massachusetts General Hospital, McDonnell Genome Institute at Washington University, Medical College of Wisconsin, Medical University of South Carolina, Memorial Sloan Kettering Cancer Center, Montefiore Medical Center, NantOmics, National Cancer Institute, National Hospital, Abuja, Nigeria, National Human Genome Research Institute, National Institute of Environmental Health Sciences, National Institute on Deafness &Other Communication Disorders, Ontario Tumour Bank, London Health Sciences Centre, Ontario Tumour Bank, Ontario Institute for Cancer Research, Ontario Tumour Bank, The Ottawa Hospital, Oregon Health &Science University, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, SRA International, St Joseph's Candler Health System, Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University, Research Institute at Nationwide Children's Hospital, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, University of Bergen, University of Texas MD Anderson Cancer Center, University of Abuja Teaching Hospital, University of Alabama at Birmingham, University of California, Irvine, University of California Santa Cruz, University of Kansas Medical Center, University of Lausanne, University of New Mexico Health Sciences Center, University of North Carolina at Chapel Hill, University of Oklahoma Health Sciences Center, University of Pittsburgh, University of São Paulo, Ribeir ão Preto Medical School, University of Southern California, University of Washington, University of Wisconsin School of Medicine &Public Health, Van Andel Research Institute, Washington University in St Louis
(2017) Nature 543: 378-384 - Promoting apoptosis as a strategy for cancer drug discovery.
Fesik SW
(2005) Nat Rev Cancer 5: 876-85 - Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
Conn PJ, Christopoulos A, Lindsley CW
(2009) Nat Rev Drug Discov 8: 41-54 - Evidence for a differential avidity model of T cell selection in the thymus.
Ashton-Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher HP, Zinkernagel RM, Tonegawa S
(1994) Cell 76: 651-63 - Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V, Conn PJ, Stevens RC
(2014) Science 344: 58-64 - Discovering high-affinity ligands for proteins: SAR by NMR.
Shuker SB, Hajduk PJ, Meadows RP, Fesik SW
(1996) Science 274: 1531-4 - Discovering high-affinity ligands for proteins.
Hajduk PJ, Meadows RP, Fesik SW
(1997) Science 278: 497,499 - The tail of integrins, talin, and kindlins.
Moser M, Legate KR, Zent R, Fässler R
(2009) Science 324: 895-9 - Suppression of aging in mice by the hormone Klotho.
Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M
(2005) Science 309: 1829-33 - Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.
Brown CB, Boyer AS, Runyan RB, Barnett JV
(1999) Science 283: 2080-2 - An essential role for ectodomain shedding in mammalian development.
Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA
(1998) Science 282: 1281-4 - Structural basis for integration of GluD receptors within synaptic organizer complexes.
Elegheert J, Kakegawa W, Clay JE, Shanks NF, Behiels E, Matsuda K, Kohda K, Miura E, Rossmann M, Mitakidis N, Motohashi J, Chang VT, Siebold C, Greger IH, Nakagawa T, Yuzaki M, Aricescu AR
(2016) Science 353: 295-9 - Dopaminergic network differences in human impulsivity.
Buckholtz JW, Treadway MT, Cowan RL, Woodward ND, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Shelby ES, Smith CE, Kessler RM, Zald DH
(2010) Science 329: 532 - Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol.
Joyce S, Woods AS, Yewdell JW, Bennink JR, De Silva AD, Boesteanu A, Balk SP, Cotter RJ, Brutkiewicz RR
(1998) Science 279: 1541-4 - Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants.
Ramamoorthy S, Blakely RD
(1999) Science 285: 763-6 - MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.
Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK, Vargo-Gogola TC, Begtrup JL, Peterson TE, Fingleton B, Shirai T, Matrisian LM, Futakuchi M
(2005) Cancer Cell 7: 485-96 - The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice.
Hong S, Wilson MT, Serizawa I, Wu L, Singh N, Naidenko OV, Miura T, Haba T, Scherer DC, Wei J, Kronenberg M, Koezuka Y, Van Kaer L
(2001) Nat Med 7: 1052-6 - NK cells promote islet allograft tolerance via a perforin-dependent mechanism.
Beilke JN, Kuhl NR, Van Kaer L, Gill RG
(2005) Nat Med 11: 1059-65 - Computational methods in drug discovery.
Sliwoski G, Kothiwale S, Meiler J, Lowe EW
(2014) Pharmacol Rev 66: 334-95 - Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells.
Singh B, Coffey RJ
(2014) Annu Rev Physiol 76: 275-300 - The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia.
Arteaga CL
(2001) J Clin Oncol 19: 32S-40S - Neurotrophins live or let die: does p75NTR decide?
Carter BD, Lewin GR
(1997) Neuron 18: 187-90 - Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.
Kenchappa RS, Zampieri N, Chao MV, Barker PA, Teng HK, Hempstead BL, Carter BD
(2006) Neuron 50: 219-32 - Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.
Li Y, Choi M, Cavey G, Daugherty J, Suino K, Kovach A, Bingham NC, Kliewer SA, Xu HE
(2005) Mol Cell 17: 491-502 - Structural basis for bile acid binding and activation of the nuclear receptor FXR.
Mi LZ, Devarakonda S, Harp JM, Han Q, Pellicciari R, Willson TM, Khorasanizadeh S, Rastinejad F
(2003) Mol Cell 11: 1093-100 - Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A.
Zheng F, Erreger K, Low CM, Banke T, Lee CJ, Conn PJ, Traynelis SF
(2001) Nat Neurosci 4: 894-901 - Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension.
Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, Weyand CM, Harrison DG, Guzik TJ
(2010) Circulation 122: 2529-37 - ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae.
Elefteriou F, Benson MD, Sowa H, Starbuck M, Liu X, Ron D, Parada LF, Karsenty G
(2006) Cell Metab 4: 441-51 - Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state.
Kenny PW, Newman J, Peat TS
(2014) Acta Crystallogr D Biol Crystallogr 70: 565-71 - A preliminary time-of-flight neutron diffraction study of Streptomyces rubiginosus D-xylose isomerase.
Hanson BL, Langan P, Katz AK, Li X, Harp JM, Glusker JP, Schoenborn BP, Bunick GJ
(2004) Acta Crystallogr D Biol Crystallogr 60: 241-9
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