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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Publications
- DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A, Walz C, Wiemels JL, Segal MR, Adès L, Blair IA, Osheroff N, Peniket AJ, Lafage-Pochitaloff M, Cross NC, Chomienne C, Solomon E, Fenaux P, Grimwade D
(2005) N Engl J Med 352: 1529-38 - Telomere dysfunction induces metabolic and mitochondrial compromise.
Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA
(2011) Nature 470: 359-65 - p53 status and the efficacy of cancer therapy in vivo.
Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T
(1994) Science 266: 807-10 - Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.
Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A
(2017) Cancer Cell 31: 142-156 - Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta.
Chinery R, Brockman JA, Peeler MO, Shyr Y, Beauchamp RD, Coffey RJ
(1997) Nat Med 3: 1233-41 - Intensive preoperative chemotherapy with colony-stimulating factor for resectable adenocarcinoma of the esophagus or gastroesophageal junction.
Ajani JA, Roth JA, Ryan MB, Putnam JB, Pazdur R, Levin B, Gutterman JU, McMurtrey M
(1993) J Clin Oncol 11: 22-8 - High-dose cisplatin combination chemotherapy in the treatment of advanced epithelial ovarian carcinoma.
Hainsworth JD, Burnett LS, Jones HW, Grosh WW, Johnson DH, Greco FA
(1990) J Clin Oncol 8: 502-8 - Combined small-cell and non-small-cell lung cancer.
Mangum MD, Greco FA, Hainsworth JD, Hande KR, Johnson DH
(1989) J Clin Oncol 7: 607-12 - Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity.
Sawyer DB, Zuppinger C, Miller TA, Eppenberger HM, Suter TM
(2002) Circulation 105: 1551-4 - Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration.
Brissova M, Aamodt K, Brahmachary P, Prasad N, Hong JY, Dai C, Mellati M, Shostak A, Poffenberger G, Aramandla R, Levy SE, Powers AC
(2014) Cell Metab 19: 498-511 - Peritoneal carcinomatosis of unknown primary site in women. A distinctive subset of adenocarcinoma.
Strnad CM, Grosh WW, Baxter J, Burnett LS, Jones HW, Greco FA, Hainsworth JD
(1989) Ann Intern Med 111: 213-7 - Advanced ovarian cancer: long-term results of treatment with intensive cisplatin-based chemotherapy of brief duration.
Hainsworth JD, Grosh WW, Burnett LS, Jones HW, Wolff SN, Greco FA
(1988) Ann Intern Med 108: 165-70 - Serial micropuncture analysis of glomerular function in two rat models of glomerular sclerosis.
Fogo A, Yoshida Y, Glick AD, Homma T, Ichikawa I
(1988) J Clin Invest 82: 322-30 - Image-guided local delivery strategies enhance therapeutic nanoparticle uptake in solid tumors.
Mouli SK, Tyler P, McDevitt JL, Eifler AC, Guo Y, Nicolai J, Lewandowski RJ, Li W, Procissi D, Ryu RK, Wang YA, Salem R, Larson AC, Omary RA
(2013) ACS Nano 7: 7724-33 - Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
Eischen CM, Kottke TJ, Martins LM, Basi GS, Tung JS, Earnshaw WC, Leibson PJ, Kaufmann SH
(1997) Blood 90: 935-43 - Overexpression of cyclooxygenase-2 predisposes to podocyte injury.
Cheng H, Wang S, Jo YI, Hao CM, Zhang M, Fan X, Kennedy C, Breyer MD, Moeckel GW, Harris RC
(2007) J Am Soc Nephrol 18: 551-9 - Inhibition of integrin α2β1 ameliorates glomerular injury.
Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A
(2012) J Am Soc Nephrol 23: 1027-38 - Distinct roles for basal and induced COX-2 in podocyte injury.
Cheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC
(2009) J Am Soc Nephrol 20: 1953-62 - Predominant cytosolic localization of type II transforming growth factor beta receptors in human breast carcinoma cells.
Koli KM, Arteaga CL
(1997) Cancer Res 57: 970-7 - G-protein inactivator RGS6 mediates myocardial cell apoptosis and cardiomyopathy caused by doxorubicin.
Yang J, Maity B, Huang J, Gao Z, Stewart A, Weiss RM, Anderson ME, Fisher RA
(2013) Cancer Res 73: 1662-7 - PI3-kinase and TGF-β in glomerular nephropathy: which comes first?
Pozzi A
(2012) Kidney Int 82: 507-9 - p47(phox) contributes to albuminuria and kidney fibrosis in mice.
Wang H, Chen X, Su Y, Paueksakon P, Hu W, Zhang MZ, Harris RC, Blackwell TS, Zent R, Pozzi A
(2015) Kidney Int 87: 948-62 - Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy.
Tang SC, Leung JC, Chan LY, Eddy AA, Lai KN
(2008) Kidney Int 73: 288-99 - Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.
Grohar PJ, Segars LE, Yeung C, Pommier Y, D'Incalci M, Mendoza A, Helman LJ
(2014) Clin Cancer Res 20: 1190-203 - Adenovirus E1A expression enhances the sensitivity of an ovarian cancer cell line to multiple cytotoxic agents through an apoptotic mechanism.
Brader KR, Wolf JK, Hung MC, Yu D, Crispens MA, van Golen KL, Price JE
(1997) Clin Cancer Res 3: 2017-24 - Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner.
Stewart ZA, Tang LJ, Pietenpol JA
(2001) Oncogene 20: 113-24 - Cell cycle re-entry following chemically-induced cell cycle synchronization leads to elevated p53 and p21 protein levels.
Ji C, Marnett LJ, Pietenpol JA
(1997) Oncogene 15: 2749-53 - Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.
Steelman LS, Navolanic PM, Sokolosky ML, Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Wong EW, Stadelman KM, Terrian DM, Leslie NR, Martelli AM, Stivala F, Libra M, Franklin RA, McCubrey JA
(2008) Oncogene 27: 4086-95 - Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.
Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Steelman LS, McCubrey JA
(2011) Oncotarget 2: 610-26 - Induction of cell cycle arrest by the endogenous product of lipid peroxidation, malondialdehyde.
Ji C, Rouzer CA, Marnett LJ, Pietenpol JA
(1998) Carcinogenesis 19: 1275-83 - Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine.
Barthel BL, Zhang Z, Rudnicki DL, Coldren CD, Polinkovsky M, Sun H, Koch GG, Chan DC, Koch TH
(2009) J Med Chem 52: 7678-88 - Seven-tesla magnetic resonance imaging accurately quantifies intratumoral uptake of therapeutic nanoparticles in the McA rat model of hepatocellular carcinoma: preclinical study in a rodent model.
Tyler PD, McDevitt JL, Sheu AY, Nicolai J, Procissi D, Ragin AB, Lewandowski RJ, Salem R, Larson AC, Omary RA
(2014) Invest Radiol 49: 87-92 - E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis.
Nip J, Strom DK, Fee BE, Zambetti G, Cleveland JL, Hiebert SW
(1997) Mol Cell Biol 17: 1049-56 - Thymoma. A retrospective study of 87 cases.
Park HS, Shin DM, Lee JS, Komaki R, Pollack A, Putnam JB, Cox JD, Hong WK
(1994) Cancer 73: 2491-8 - Vinorelbine, doxorubicin, and prednisone in androgen-independent prostate cancer.
Borden LS, Clark PE, Lovato J, Hall MC, Stindt D, Harmon M, M Mohler R, Torti FM
(2006) Cancer 107: 1093-100 - Induction of manganese superoxide dismutase (MnSOD) mediates cardioprotective effect of tamoxifen (TAM).
Daosukho C, Ittarat W, Lin SM, Sawyer DB, Kiningham K, Lien YC, St Clair DK
(2005) J Mol Cell Cardiol 39: 792-803 - Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes.
Lim CC, Zuppinger C, Guo X, Kuster GM, Helmes M, Eppenberger HM, Suter TM, Liao R, Sawyer DB
(2004) J Biol Chem 279: 8290-9 - Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.
Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H
(2003) J Biol Chem 278: 21767-73 - Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.
Liu Y, Li PK, Li C, Lin J
(2010) J Biol Chem 285: 27429-27439 - 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells.
Wang SF, Chou YC, Mazumder N, Kao FJ, Nagy LD, Guengerich FP, Huang C, Lee HC, Lai PS, Ueng YF
(2013) Biochem Pharmacol 86: 548-60
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