Response to Comments on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport". O'Brien E, Holt ME, Thompson MK, Salay LE, Ehlinger AC, Chazin WJ, Barton JK (2017) Science 357: The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport. O'Brien E, Holt ME, Thompson MK, Salay LE, Ehlinger AC, Chazin WJ, Barton JK (2017) Science 355: Substrate Binding Regulates Redox Signaling in Human DNA Primase. O'Brien E, Holt ME, Salay LE, Chazin WJ, Barton JK (2018) J Am Chem Soc 140: 17153-17162 Molecular basis for PrimPol recruitment to replication forks by RPA. Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ (2017) Nat Commun 8: 15222 Yeast require redox switching in DNA primase. O'Brien E, Salay LE, Epum EA, Friedman KL, Chazin WJ, Barton JK (2018) Proc Natl Acad Sci U S A 115: 13186-13191 Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase. Vaithiyalingam S, Warren EM, Eichman BF, Chazin WJ (2010) Proc Natl Acad Sci U S A 107: 13684-9 Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins. Guilliam TA, Jozwiakowski SK, Ehlinger A, Barnes RP, Rudd SG, Bailey LJ, Skehel JM, Eckert KA, Chazin WJ, Doherty AJ (2015) Nucleic Acids Res 43: 1056-68 An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. Weiner BE, Huang H, Dattilo BM, Nilges MJ, Fanning E, Chazin WJ (2007) J Biol Chem 282: 33444-33451 Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome. Huang H, Weiner BE, Zhang H, Fuller BE, Gao Y, Wile BM, Zhao K, Arnett DR, Chazin WJ, Fanning E (2010) J Biol Chem 285: 17112-22 Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase. Vaithiyalingam S, Arnett DR, Aggarwal A, Eichman BF, Fanning E, Chazin WJ (2014) J Mol Biol 426: 558-69 Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs. Holt ME, Salay LE, O'Brien E, Barton JK, Chazin WJ (2018) PLoS One 13: e0209345 Analysis of Functional Dynamics of Modular Multidomain Proteins by SAXS and NMR. Thompson MK, Ehlinger AC, Chazin WJ (2017) Methods Enzymol 592: 49-76 A Polymerase With Potential: The Fe-S Cluster in Human DNA Primase. Holt ME, Salay LE, Chazin WJ (2017) Methods Enzymol 595: 361-390
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