Keyword Connections

•  Carlos Arteaga
•  Peggy Kendall

•  Takamune Takahashi
•  Virginia Shepherd

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Publications

• Cardiovascular Toxic Effects of Targeted Cancer Therapies.
  Moslehi JJ
  (2016) N Engl J Med 375: 1457-1467
• Reversible cardiomyopathy associated with sunitinib and sorafenib.
  Uraizee I, Cheng S, Moslehi J
  (2011) N Engl J Med 365: 1649-50
• Cancer-drug discovery and cardiovascular surveillance.
  Groarke JD, Cheng S, Moslehi J
  (2013) N Engl J Med 369: 1779-81
• Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine.
  Redmond DE, Sladek JR, Roth RH, Collier TJ, Elsworth JD, Deutch AY, Haber S
  (1986) Lancet 1: 1125-7
• Syk tyrosine kinase required for mouse viability and B-cell development.
  Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T
  (1995) Nature 378: 303-6
• Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.
  Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV
  (1996) Nature 383: 716-9
• Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis.
  Gould KL, Nurse P
  (1989) Nature 342: 39-45
• Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
  Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW
  (1995) Nature 378: 584-92
• Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
  Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS
  (2010) Nature 468: 973-7
• Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
  Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
  (2012) Nature 487: 505-9
• Intoxicated cells and stomach ulcers.
  Peek RM
  (2003) Nat Genet 33: 328-30
• Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer.
  Pao W, Chmielecki J
  (2010) Nat Rev Cancer 10: 760-74
• Single cell profiling of potentiated phospho-protein networks in cancer cells.
  Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud Ø, Gjertsen BT, Nolan GP
  (2004) Cell 118: 217-28
• Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.
  Lau KS, Partridge EA, Grigorian A, Silvescu CI, Reinhold VN, Demetriou M, Dennis JW
  (2007) Cell 129: 123-34
• Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.
  Gould KL, Moreno S, Tonks NK, Nurse P
  (1990) Science 250: 1573-6
• Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila.
  LaFever L, Drummond-Barbosa D
  (2005) Science 309: 1071-3
• Interleukin-4 and interleukin-13 signaling connections maps.
  Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD
  (2003) Science 300: 1527-8
• Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.
  Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhäuser N, Böhm-Matthaei R, Baeuerle PA, Barde YA
  (1996) Science 272: 542-5
• New driver mutations in non-small-cell lung cancer.
  Pao W, Girard N
  (2011) Lancet Oncol 12: 175-80
• Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
  Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S
  (2005) Cancer Cell 8: 155-67
• Tyrosine kinase inhibitors: why does the current process of clinical development not apply to them?
  Arteaga CL, Baselga J
  (2004) Cancer Cell 5: 525-31
• Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data.
  Tyson DR, Garbett SP, Frick PL, Quaranta V
  (2012) Nat Methods 9: 923-8
• Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.
  Lovly CM, McDonald NT, Chen H, Ortiz-Cuaran S, Heukamp LC, Yan Y, Florin A, Ozretić L, Lim D, Wang L, Chen Z, Chen X, Lu P, Paik PK, Shen R, Jin H, Buettner R, Ansén S, Perner S, Brockmann M, Bos M, Wolf J, Gardizi M, Wright GM, Solomon B, Russell PA, Rogers TM, Suehara Y, Red-Brewer M, Tieu R, de Stanchina E, Wang Q, Zhao Z, Johnson DH, Horn L, Wong KK, Thomas RK, Ladanyi M, Pao W
  (2014) Nat Med 20: 1027-34
• RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
  Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, Okimoto RA, Lin L, Neel DS, Sabnis A, Flanagan J, Chan E, Varella-Garcia M, Aisner DL, Vaishnavi A, Ou SH, Collisson EA, Ichihara E, Mack PC, Lovly CM, Karachaliou N, Rosell R, Riess JW, Doebele RC, Bivona TG
  (2015) Nat Med 21: 1038-47
• Chipping away at the lung cancer genome.
  Pao W, Hutchinson KE
  (2012) Nat Med 18: 349-51
• Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation.
  Phillips N, Hayward RD, Koronakis V
  (2004) Nat Cell Biol 6: 618-25
• The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.
  Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD
  (2013) Nat Cell Biol 15: 677-87
• Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer.
  Miller VA, Kris MG, Shah N, Patel J, Azzoli C, Gomez J, Krug LM, Pao W, Rizvi N, Pizzo B, Tyson L, Venkatraman E, Ben-Porat L, Memoli N, Zakowski M, Rusch V, Heelan RT
  (2004) J Clin Oncol 22: 1103-9
• Extended Survival and Prognostic Factors for Patients With ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastasis.
  Johung KL, Yeh N, Desai NB, Williams TM, Lautenschlaeger T, Arvold ND, Ning MS, Attia A, Lovly CM, Goldberg S, Beal K, Yu JB, Kavanagh BD, Chiang VL, Camidge DR, Contessa JN
  (2016) J Clin Oncol 34: 123-9
• ROS1 rearrangements define a unique molecular class of lung cancers.
  Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, McDonald NT, Massion PP, Siwak-Tapp C, Gonzalez A, Fang R, Mark EJ, Batten JM, Chen H, Wilner KD, Kwak EL, Clark JW, Carbone DP, Ji H, Engelman JA, Mino-Kenudson M, Pao W, Iafrate AJ
  (2012) J Clin Oncol 30: 863-70
• Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers.
  Guix M, Granja Nde M, Meszoely I, Adkins TB, Wieman BM, Frierson KE, Sanchez V, Sanders ME, Grau AM, Mayer IA, Pestano G, Shyr Y, Muthuswamy S, Calvo B, Krontiras H, Krop IE, Kelley MC, Arteaga CL
  (2008) J Clin Oncol 26: 897-906
• Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.
  Ihrie RA, Shah JK, Harwell CC, Levine JH, Guinto CD, Lezameta M, Kriegstein AR, Alvarez-Buylla A
  (2011) Neuron 71: 250-62
• Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses.
  Ramikie TS, Nyilas R, Bluett RJ, Gamble-George JC, Hartley ND, Mackie K, Watanabe M, Katona I, Patel S
  (2014) Neuron 81: 1111-1125
• 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.
  Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME
  (2000) Mol Cell 6: 41-51